Hydrogen Bonding Nanoarchitectonics of Organic Pigment-Based Janus Microrobots with Entering Capability into Cancer Cells

Anna Jancik-Prochazkova, Hana Michalkova, Zbynek Heger, Martin Pumera

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1 Citation (Scopus)


Autonomous microrobots are at the forefront of biomedical research as they are expected to be applied for specific tasks at the intracellular level such as cargo delivery, sensing, molecular manipulation, among others. Here, we report on a preparation of microrobots based on quinacridone and indigo, which are members of the organic hydrogen-bonded pigment family. The microrobots were fabricated by asymmetric platinum deposition on corresponding quinacridone and indigo microparticles that possessed a homogeneous size and shape distribution. The microrobots exhibited autonomous locomotion in the presence of hydrogen peroxide, which was further supported by UV irradiation. The organic pigment-based microrobots were studied in the presence of mouse colorectal carcinoma cells, and it was observed that they were internalized into the cells. Internalization was visualized using confocal laser scanning microscopy. This study reveals the possibility of fabricating hydrogen-bonded organic pigment-based microrobots for biomedical applications by employing the principles of nanoarchitectonics.

Original languageEnglish
Pages (from-to)146-156
Number of pages11
JournalACS Nano
Issue number1
Publication statusPublished - 2023 Jan 10

Bibliographical note

Funding Information:
This work was supported by the project Advanced Functional Nanorobots (Reg. No. CZ.02.1.01/0.0/0.0/15_003/0000444 financed by the EFRR). CzechNanoLab project LM2018110 funded by MEYS CR is gratefully acknowledged for the financial support of the measurements at CEITEC Nano Research Infrastructure.

Publisher Copyright:
© 2022 American Chemical Society.

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)


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