Abstract
Autonomous microrobots are at the forefront of biomedical research as they are expected to be applied for specific tasks at the intracellular level such as cargo delivery, sensing, molecular manipulation, among others. Here, we report on a preparation of microrobots based on quinacridone and indigo, which are members of the organic hydrogen-bonded pigment family. The microrobots were fabricated by asymmetric platinum deposition on corresponding quinacridone and indigo microparticles that possessed a homogeneous size and shape distribution. The microrobots exhibited autonomous locomotion in the presence of hydrogen peroxide, which was further supported by UV irradiation. The organic pigment-based microrobots were studied in the presence of mouse colorectal carcinoma cells, and it was observed that they were internalized into the cells. Internalization was visualized using confocal laser scanning microscopy. This study reveals the possibility of fabricating hydrogen-bonded organic pigment-based microrobots for biomedical applications by employing the principles of nanoarchitectonics.
| Original language | English |
|---|---|
| Pages (from-to) | 146-156 |
| Number of pages | 11 |
| Journal | ACS Nano |
| Volume | 17 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2023 Jan 10 |
Bibliographical note
Funding Information:This work was supported by the project Advanced Functional Nanorobots (Reg. No. CZ.02.1.01/0.0/0.0/15_003/0000444 financed by the EFRR). CzechNanoLab project LM2018110 funded by MEYS CR is gratefully acknowledged for the financial support of the measurements at CEITEC Nano Research Infrastructure.
Publisher Copyright:
© 2022 American Chemical Society.
All Science Journal Classification (ASJC) codes
- Materials Science(all)
- Engineering(all)
- Physics and Astronomy(all)
