Hydroxypropyl methylcellulose-graft-poly(ethyl acrylate-co-methyl methacrylate) particles by resin-fortified emulsion polymerization

Hyon Ho Baek, Jung Min Lee, Ji Eun Cho, Jin Hun Cho, Jung Hyun Kim, In Woo Cheong

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This article describes the preparation and characterization of hydroxypropyl methylcellulose-graft-poly(ethylacrylate-co-methyl methacrylate) particles [HPMC-g-poly(EA-co-MMA) NPs]. The particles were prepared by resin-fortified emulsion polymerization using ceric ammonium nitrate (CAN). In this study, a series of HPMC-g-poly(EA-co-MMA) NPs were synthesized by varying the CAN: HPMC and HPMC: (EA/MMA) ratios to determine the effects of these variables on the physical properties of HPMC-g-poly(EA-co-MMA) as well as the dissolution behavior of an aspirin tablet, as a model drug. The drug dissolution profiles of the coated tablets were affected significantly by the HPMC: (EA/MMA) molar ratio.

Original languageEnglish
Pages (from-to)53-58
Number of pages6
JournalMacromolecular Research
Volume18
Issue number1
DOIs
Publication statusPublished - 2010 Jan 1

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Hydroxypropyl methylcellulose-graft-poly(ethyl acrylate-co-methyl methacrylate) particles by resin-fortified emulsion polymerization'. Together they form a unique fingerprint.

  • Cite this