This article describes the preparation and characterization of hydroxypropyl methylcellulose-graft-poly(ethylacrylate-co-methyl methacrylate) particles [HPMC-g-poly(EA-co-MMA) NPs]. The particles were prepared by resin-fortified emulsion polymerization using ceric ammonium nitrate (CAN). In this study, a series of HPMC-g-poly(EA-co-MMA) NPs were synthesized by varying the CAN: HPMC and HPMC: (EA/MMA) ratios to determine the effects of these variables on the physical properties of HPMC-g-poly(EA-co-MMA) as well as the dissolution behavior of an aspirin tablet, as a model drug. The drug dissolution profiles of the coated tablets were affected significantly by the HPMC: (EA/MMA) molar ratio.
|Number of pages||6|
|Publication status||Published - 2010 Jan|
All Science Journal Classification (ASJC) codes
- Chemical Engineering(all)
- Organic Chemistry
- Polymers and Plastics
- Materials Chemistry