Abstract
We report the synthesis of a well-defined hyperbranched double hydrophilic block copolymer of poly-(ethylene oxide)-hyperbranched-polyglycerol (PEO-hb-PG) to develop an efficient drug delivery system. In specific, we demonstrate the hyperbranched PEO-hb-PG can form a selfassembled micellar structure on conjugation with the hydrophobic anticancer agent doxorubicin, which is linked to the polymer by pH-sensitive hydrazone bonds, resulting in a pHresponsive controlled release of doxorubicin. Dynamic light scattering, atomic force microscopy, and transmission electron microscopy demonstrated successful formation of the spherical core-shell type micelles with an average size of about 200 nm. Moreover, the pH-responsive release of doxorubicin and in vitro cytotoxicity studies revealed the controlled stimuli-responsive drug delivery system desirable for enhanced efficiency. Benefiting from many desirable features of hyperbranched double hydrophilic block copolymers such as enhanced biocompatibility, increased water solubility, and drug loading efficiency as well as improved clearance of the polymer after drug release, we believe that double hydrophilic block copolymer will provide a versatile platform to develop excellent drug delivery systems for effective treatment of cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 1190-1196 |
| Number of pages | 7 |
| Journal | Biomacromolecules |
| Volume | 13 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2012 Apr 9 |
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All Science Journal Classification (ASJC) codes
- Bioengineering
- Biomaterials
- Polymers and Plastics
- Materials Chemistry
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Hyperbranched double hydrophilic block copolymer micelles of poly(ethylene oxide) and polyglycerol for pH-responsive drug delivery. / Lee, Sueun; Saito, Kyohei; Lee, Hye Ra; Lee, Min Jae; Shibasaki, Yuji; Oishi, Yoshiyuki; Kim, Byeong Su.
In: Biomacromolecules, Vol. 13, No. 4, 09.04.2012, p. 1190-1196.Research output: Contribution to journal › Article
TY - JOUR
T1 - Hyperbranched double hydrophilic block copolymer micelles of poly(ethylene oxide) and polyglycerol for pH-responsive drug delivery
AU - Lee, Sueun
AU - Saito, Kyohei
AU - Lee, Hye Ra
AU - Lee, Min Jae
AU - Shibasaki, Yuji
AU - Oishi, Yoshiyuki
AU - Kim, Byeong Su
PY - 2012/4/9
Y1 - 2012/4/9
N2 - We report the synthesis of a well-defined hyperbranched double hydrophilic block copolymer of poly-(ethylene oxide)-hyperbranched-polyglycerol (PEO-hb-PG) to develop an efficient drug delivery system. In specific, we demonstrate the hyperbranched PEO-hb-PG can form a selfassembled micellar structure on conjugation with the hydrophobic anticancer agent doxorubicin, which is linked to the polymer by pH-sensitive hydrazone bonds, resulting in a pHresponsive controlled release of doxorubicin. Dynamic light scattering, atomic force microscopy, and transmission electron microscopy demonstrated successful formation of the spherical core-shell type micelles with an average size of about 200 nm. Moreover, the pH-responsive release of doxorubicin and in vitro cytotoxicity studies revealed the controlled stimuli-responsive drug delivery system desirable for enhanced efficiency. Benefiting from many desirable features of hyperbranched double hydrophilic block copolymers such as enhanced biocompatibility, increased water solubility, and drug loading efficiency as well as improved clearance of the polymer after drug release, we believe that double hydrophilic block copolymer will provide a versatile platform to develop excellent drug delivery systems for effective treatment of cancer.
AB - We report the synthesis of a well-defined hyperbranched double hydrophilic block copolymer of poly-(ethylene oxide)-hyperbranched-polyglycerol (PEO-hb-PG) to develop an efficient drug delivery system. In specific, we demonstrate the hyperbranched PEO-hb-PG can form a selfassembled micellar structure on conjugation with the hydrophobic anticancer agent doxorubicin, which is linked to the polymer by pH-sensitive hydrazone bonds, resulting in a pHresponsive controlled release of doxorubicin. Dynamic light scattering, atomic force microscopy, and transmission electron microscopy demonstrated successful formation of the spherical core-shell type micelles with an average size of about 200 nm. Moreover, the pH-responsive release of doxorubicin and in vitro cytotoxicity studies revealed the controlled stimuli-responsive drug delivery system desirable for enhanced efficiency. Benefiting from many desirable features of hyperbranched double hydrophilic block copolymers such as enhanced biocompatibility, increased water solubility, and drug loading efficiency as well as improved clearance of the polymer after drug release, we believe that double hydrophilic block copolymer will provide a versatile platform to develop excellent drug delivery systems for effective treatment of cancer.
UR - http://www.scopus.com/inward/record.url?scp=84860726945&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860726945&partnerID=8YFLogxK
U2 - 10.1021/bm300151m
DO - 10.1021/bm300151m
M3 - Article
C2 - 22414172
AN - SCOPUS:84860726945
VL - 13
SP - 1190
EP - 1196
JO - Biomacromolecules
JF - Biomacromolecules
SN - 1525-7797
IS - 4
ER -