Hyperfractionated re-irradiation using a 3-dimensional conformal technique for locally recurrent carcinoma of the nasopharynx; preliminary results.

J. H. Cho, G. E. Kim, K. H. Cho, C. G. Lee, Y. B. Kim, S. W. Lee, K. C. Keum, C. O. Suh

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To evaluate the efficacy of hyperfractionated re-irradiation using a three-dimensional conformal radiotherapy (3-D CRT) technique in patients with locally recurrent carcinoma of the nasopharynx. Four patients with locally recurrent nasopharyngeal cancer were retreated with a hyperfractionated schedule using a 3-D CRT technique. Re-irradiation was delivered in 1.1-1.2 Gy fractions twice per day (BID), with interfraction intervals of more than 6 hours. The total dose ranged from 59.4 to 69.2 Gy. A 3-D CRT technique with 5- or 6-field coplanar and/or non-coplanar beams were employed during the entire treatment procedure. All four patients achieved complete remission of locally recurrent lesions, with marked improvement of subjective symptoms, immediately after re-irradiation. All are alive and well without evidence of disease after limited follow-up periods, which range from 7 to 20 months. So far, there have been no radiation-induced neurologic complications. Four patients with locally recurrent carcinoma of the nasopharynx were successfully treated by hyperfractionated re-irradiation using a 3-D CRT technique. A relatively high re-irradiation dose of more than 60 Gy may be safely delivered with no serious acute or late radiation-induced complications in patients with local recurrences and who were initially treated with doses greater than 70 Gy.

Original languageEnglish
Pages (from-to)55-64
Number of pages10
JournalYonsei medical journal
Volume42
Issue number1
DOIs
Publication statusPublished - 2001 Feb

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Nasopharynx
Carcinoma
Radiation
Nasopharyngeal Neoplasms
Conformal Radiotherapy
Nervous System
Appointments and Schedules
Re-Irradiation
Recurrence

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Hyperfractionated re-irradiation using a 3-dimensional conformal technique for locally recurrent carcinoma of the nasopharynx; preliminary results.",
abstract = "To evaluate the efficacy of hyperfractionated re-irradiation using a three-dimensional conformal radiotherapy (3-D CRT) technique in patients with locally recurrent carcinoma of the nasopharynx. Four patients with locally recurrent nasopharyngeal cancer were retreated with a hyperfractionated schedule using a 3-D CRT technique. Re-irradiation was delivered in 1.1-1.2 Gy fractions twice per day (BID), with interfraction intervals of more than 6 hours. The total dose ranged from 59.4 to 69.2 Gy. A 3-D CRT technique with 5- or 6-field coplanar and/or non-coplanar beams were employed during the entire treatment procedure. All four patients achieved complete remission of locally recurrent lesions, with marked improvement of subjective symptoms, immediately after re-irradiation. All are alive and well without evidence of disease after limited follow-up periods, which range from 7 to 20 months. So far, there have been no radiation-induced neurologic complications. Four patients with locally recurrent carcinoma of the nasopharynx were successfully treated by hyperfractionated re-irradiation using a 3-D CRT technique. A relatively high re-irradiation dose of more than 60 Gy may be safely delivered with no serious acute or late radiation-induced complications in patients with local recurrences and who were initially treated with doses greater than 70 Gy.",
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Hyperfractionated re-irradiation using a 3-dimensional conformal technique for locally recurrent carcinoma of the nasopharynx; preliminary results. / Cho, J. H.; Kim, G. E.; Cho, K. H.; Lee, C. G.; Kim, Y. B.; Lee, S. W.; Keum, K. C.; Suh, C. O.

In: Yonsei medical journal, Vol. 42, No. 1, 02.2001, p. 55-64.

Research output: Contribution to journalArticle

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AU - Kim, G. E.

AU - Cho, K. H.

AU - Lee, C. G.

AU - Kim, Y. B.

AU - Lee, S. W.

AU - Keum, K. C.

AU - Suh, C. O.

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