Abstract
Background: EUS is an accurate imaging modality for delineating gallbladder (GB) structures; however, its clinical use in differentiating neoplastic GB polyps from nonneoplastic polyps is limited. Thus, we sought to characterize neoplastic GB polyps by analyzing unique EUS features. Our analysis revealed variably shaped, relatively hypoechoic portions in the core of polyps compared with general background echogenicity. Objective: Our purpose was to make a differential diagnosis between neoplastic and nonneoplastic GB polyps of less than 20 mm by use of EUS variables, including hypoechoic foci. Design: Retrospective single-center study. Setting: University teaching hospital. Patients: Patients (n = 88) underwent preoperative EUS and cholecystectomy for GB polyps smaller than 20 mm. Results: Hypoechoic foci were found in 30 of 33 patients (91%) with neoplastic polyps and 6 of 55 (11%) with nonneoplastic polyps. In a multivariate analysis, hypoechoic foci were the only significant predictive factor for neoplastic polyps (odds ratio [OR] 55.4, 95% CI, 8.26-371, P < .001); the sensitivity and specificity were 90% and 89%, respectively. In addition, polyps >15 mm had an increased risk of malignancy (OR 21.7, 95% CI, 2.35-201, P = .007), as did those with hypoechoic foci (OR 10.9; 95% CI, 1.01-117, P = .049). Limitations: Retrospective review of selected patients from a tertiary medical center. Conclusions: The presence of hypoechoic foci on EUS is a strong predictive factor for neoplastic polyps. EUS may be useful in developing a treatment strategy for GB polyps.
| Original language | English |
|---|---|
| Pages (from-to) | 1244-1250 |
| Number of pages | 7 |
| Journal | Gastrointestinal Endoscopy |
| Volume | 69 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2009 Jun 1 |
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All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging
- Gastroenterology
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Hypoechoic foci on EUS are simple and strong predictive factors for neoplastic gallbladder polyps. / Cho, Jae Hee; Park, Jeong Youp; Kim, Yoon Jae; Kim, Hee Man; Kim, Hong Jeong; Hong, Sung Pil; Park, Seung Woo; Chung, Jae Bock; Song, Si Young; Bang, Seungmin.
In: Gastrointestinal Endoscopy, Vol. 69, No. 7, 01.06.2009, p. 1244-1250.Research output: Contribution to journal › Article
TY - JOUR
T1 - Hypoechoic foci on EUS are simple and strong predictive factors for neoplastic gallbladder polyps
AU - Cho, Jae Hee
AU - Park, Jeong Youp
AU - Kim, Yoon Jae
AU - Kim, Hee Man
AU - Kim, Hong Jeong
AU - Hong, Sung Pil
AU - Park, Seung Woo
AU - Chung, Jae Bock
AU - Song, Si Young
AU - Bang, Seungmin
PY - 2009/6/1
Y1 - 2009/6/1
N2 - Background: EUS is an accurate imaging modality for delineating gallbladder (GB) structures; however, its clinical use in differentiating neoplastic GB polyps from nonneoplastic polyps is limited. Thus, we sought to characterize neoplastic GB polyps by analyzing unique EUS features. Our analysis revealed variably shaped, relatively hypoechoic portions in the core of polyps compared with general background echogenicity. Objective: Our purpose was to make a differential diagnosis between neoplastic and nonneoplastic GB polyps of less than 20 mm by use of EUS variables, including hypoechoic foci. Design: Retrospective single-center study. Setting: University teaching hospital. Patients: Patients (n = 88) underwent preoperative EUS and cholecystectomy for GB polyps smaller than 20 mm. Results: Hypoechoic foci were found in 30 of 33 patients (91%) with neoplastic polyps and 6 of 55 (11%) with nonneoplastic polyps. In a multivariate analysis, hypoechoic foci were the only significant predictive factor for neoplastic polyps (odds ratio [OR] 55.4, 95% CI, 8.26-371, P < .001); the sensitivity and specificity were 90% and 89%, respectively. In addition, polyps >15 mm had an increased risk of malignancy (OR 21.7, 95% CI, 2.35-201, P = .007), as did those with hypoechoic foci (OR 10.9; 95% CI, 1.01-117, P = .049). Limitations: Retrospective review of selected patients from a tertiary medical center. Conclusions: The presence of hypoechoic foci on EUS is a strong predictive factor for neoplastic polyps. EUS may be useful in developing a treatment strategy for GB polyps.
AB - Background: EUS is an accurate imaging modality for delineating gallbladder (GB) structures; however, its clinical use in differentiating neoplastic GB polyps from nonneoplastic polyps is limited. Thus, we sought to characterize neoplastic GB polyps by analyzing unique EUS features. Our analysis revealed variably shaped, relatively hypoechoic portions in the core of polyps compared with general background echogenicity. Objective: Our purpose was to make a differential diagnosis between neoplastic and nonneoplastic GB polyps of less than 20 mm by use of EUS variables, including hypoechoic foci. Design: Retrospective single-center study. Setting: University teaching hospital. Patients: Patients (n = 88) underwent preoperative EUS and cholecystectomy for GB polyps smaller than 20 mm. Results: Hypoechoic foci were found in 30 of 33 patients (91%) with neoplastic polyps and 6 of 55 (11%) with nonneoplastic polyps. In a multivariate analysis, hypoechoic foci were the only significant predictive factor for neoplastic polyps (odds ratio [OR] 55.4, 95% CI, 8.26-371, P < .001); the sensitivity and specificity were 90% and 89%, respectively. In addition, polyps >15 mm had an increased risk of malignancy (OR 21.7, 95% CI, 2.35-201, P = .007), as did those with hypoechoic foci (OR 10.9; 95% CI, 1.01-117, P = .049). Limitations: Retrospective review of selected patients from a tertiary medical center. Conclusions: The presence of hypoechoic foci on EUS is a strong predictive factor for neoplastic polyps. EUS may be useful in developing a treatment strategy for GB polyps.
UR - http://www.scopus.com/inward/record.url?scp=66049132532&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=66049132532&partnerID=8YFLogxK
U2 - 10.1016/j.gie.2008.10.017
DO - 10.1016/j.gie.2008.10.017
M3 - Article
C2 - 19249773
AN - SCOPUS:66049132532
VL - 69
SP - 1244
EP - 1250
JO - Gastrointestinal Endoscopy
JF - Gastrointestinal Endoscopy
SN - 0016-5107
IS - 7
ER -