Hypoechoic foci on EUS are simple and strong predictive factors for neoplastic gallbladder polyps

Jae Hee Cho, Jeong Youp Park, Yoon Jae Kim, Hee Man Kim, Hong Jeong Kim, Sung Pil Hong, Seung Woo Park, Jae Bock Chung, Si Young Song, Seungmin Bang

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: EUS is an accurate imaging modality for delineating gallbladder (GB) structures; however, its clinical use in differentiating neoplastic GB polyps from nonneoplastic polyps is limited. Thus, we sought to characterize neoplastic GB polyps by analyzing unique EUS features. Our analysis revealed variably shaped, relatively hypoechoic portions in the core of polyps compared with general background echogenicity. Objective: Our purpose was to make a differential diagnosis between neoplastic and nonneoplastic GB polyps of less than 20 mm by use of EUS variables, including hypoechoic foci. Design: Retrospective single-center study. Setting: University teaching hospital. Patients: Patients (n = 88) underwent preoperative EUS and cholecystectomy for GB polyps smaller than 20 mm. Results: Hypoechoic foci were found in 30 of 33 patients (91%) with neoplastic polyps and 6 of 55 (11%) with nonneoplastic polyps. In a multivariate analysis, hypoechoic foci were the only significant predictive factor for neoplastic polyps (odds ratio [OR] 55.4, 95% CI, 8.26-371, P < .001); the sensitivity and specificity were 90% and 89%, respectively. In addition, polyps >15 mm had an increased risk of malignancy (OR 21.7, 95% CI, 2.35-201, P = .007), as did those with hypoechoic foci (OR 10.9; 95% CI, 1.01-117, P = .049). Limitations: Retrospective review of selected patients from a tertiary medical center. Conclusions: The presence of hypoechoic foci on EUS is a strong predictive factor for neoplastic polyps. EUS may be useful in developing a treatment strategy for GB polyps.

Original languageEnglish
Pages (from-to)1244-1250
Number of pages7
JournalGastrointestinal Endoscopy
Volume69
Issue number7
DOIs
Publication statusPublished - 2009 Jun 1

Fingerprint

Polyps
Gallbladder
Odds Ratio
Cholecystectomy
Teaching Hospitals
Differential Diagnosis
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this

Cho, Jae Hee ; Park, Jeong Youp ; Kim, Yoon Jae ; Kim, Hee Man ; Kim, Hong Jeong ; Hong, Sung Pil ; Park, Seung Woo ; Chung, Jae Bock ; Song, Si Young ; Bang, Seungmin. / Hypoechoic foci on EUS are simple and strong predictive factors for neoplastic gallbladder polyps. In: Gastrointestinal Endoscopy. 2009 ; Vol. 69, No. 7. pp. 1244-1250.
@article{334ab542461d4deaa9afa190c588a26b,
title = "Hypoechoic foci on EUS are simple and strong predictive factors for neoplastic gallbladder polyps",
abstract = "Background: EUS is an accurate imaging modality for delineating gallbladder (GB) structures; however, its clinical use in differentiating neoplastic GB polyps from nonneoplastic polyps is limited. Thus, we sought to characterize neoplastic GB polyps by analyzing unique EUS features. Our analysis revealed variably shaped, relatively hypoechoic portions in the core of polyps compared with general background echogenicity. Objective: Our purpose was to make a differential diagnosis between neoplastic and nonneoplastic GB polyps of less than 20 mm by use of EUS variables, including hypoechoic foci. Design: Retrospective single-center study. Setting: University teaching hospital. Patients: Patients (n = 88) underwent preoperative EUS and cholecystectomy for GB polyps smaller than 20 mm. Results: Hypoechoic foci were found in 30 of 33 patients (91{\%}) with neoplastic polyps and 6 of 55 (11{\%}) with nonneoplastic polyps. In a multivariate analysis, hypoechoic foci were the only significant predictive factor for neoplastic polyps (odds ratio [OR] 55.4, 95{\%} CI, 8.26-371, P < .001); the sensitivity and specificity were 90{\%} and 89{\%}, respectively. In addition, polyps >15 mm had an increased risk of malignancy (OR 21.7, 95{\%} CI, 2.35-201, P = .007), as did those with hypoechoic foci (OR 10.9; 95{\%} CI, 1.01-117, P = .049). Limitations: Retrospective review of selected patients from a tertiary medical center. Conclusions: The presence of hypoechoic foci on EUS is a strong predictive factor for neoplastic polyps. EUS may be useful in developing a treatment strategy for GB polyps.",
author = "Cho, {Jae Hee} and Park, {Jeong Youp} and Kim, {Yoon Jae} and Kim, {Hee Man} and Kim, {Hong Jeong} and Hong, {Sung Pil} and Park, {Seung Woo} and Chung, {Jae Bock} and Song, {Si Young} and Seungmin Bang",
year = "2009",
month = "6",
day = "1",
doi = "10.1016/j.gie.2008.10.017",
language = "English",
volume = "69",
pages = "1244--1250",
journal = "Gastrointestinal Endoscopy",
issn = "0016-5107",
publisher = "Mosby Inc.",
number = "7",

}

Cho, JH, Park, JY, Kim, YJ, Kim, HM, Kim, HJ, Hong, SP, Park, SW, Chung, JB, Song, SY & Bang, S 2009, 'Hypoechoic foci on EUS are simple and strong predictive factors for neoplastic gallbladder polyps', Gastrointestinal Endoscopy, vol. 69, no. 7, pp. 1244-1250. https://doi.org/10.1016/j.gie.2008.10.017

Hypoechoic foci on EUS are simple and strong predictive factors for neoplastic gallbladder polyps. / Cho, Jae Hee; Park, Jeong Youp; Kim, Yoon Jae; Kim, Hee Man; Kim, Hong Jeong; Hong, Sung Pil; Park, Seung Woo; Chung, Jae Bock; Song, Si Young; Bang, Seungmin.

In: Gastrointestinal Endoscopy, Vol. 69, No. 7, 01.06.2009, p. 1244-1250.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hypoechoic foci on EUS are simple and strong predictive factors for neoplastic gallbladder polyps

AU - Cho, Jae Hee

AU - Park, Jeong Youp

AU - Kim, Yoon Jae

AU - Kim, Hee Man

AU - Kim, Hong Jeong

AU - Hong, Sung Pil

AU - Park, Seung Woo

AU - Chung, Jae Bock

AU - Song, Si Young

AU - Bang, Seungmin

PY - 2009/6/1

Y1 - 2009/6/1

N2 - Background: EUS is an accurate imaging modality for delineating gallbladder (GB) structures; however, its clinical use in differentiating neoplastic GB polyps from nonneoplastic polyps is limited. Thus, we sought to characterize neoplastic GB polyps by analyzing unique EUS features. Our analysis revealed variably shaped, relatively hypoechoic portions in the core of polyps compared with general background echogenicity. Objective: Our purpose was to make a differential diagnosis between neoplastic and nonneoplastic GB polyps of less than 20 mm by use of EUS variables, including hypoechoic foci. Design: Retrospective single-center study. Setting: University teaching hospital. Patients: Patients (n = 88) underwent preoperative EUS and cholecystectomy for GB polyps smaller than 20 mm. Results: Hypoechoic foci were found in 30 of 33 patients (91%) with neoplastic polyps and 6 of 55 (11%) with nonneoplastic polyps. In a multivariate analysis, hypoechoic foci were the only significant predictive factor for neoplastic polyps (odds ratio [OR] 55.4, 95% CI, 8.26-371, P < .001); the sensitivity and specificity were 90% and 89%, respectively. In addition, polyps >15 mm had an increased risk of malignancy (OR 21.7, 95% CI, 2.35-201, P = .007), as did those with hypoechoic foci (OR 10.9; 95% CI, 1.01-117, P = .049). Limitations: Retrospective review of selected patients from a tertiary medical center. Conclusions: The presence of hypoechoic foci on EUS is a strong predictive factor for neoplastic polyps. EUS may be useful in developing a treatment strategy for GB polyps.

AB - Background: EUS is an accurate imaging modality for delineating gallbladder (GB) structures; however, its clinical use in differentiating neoplastic GB polyps from nonneoplastic polyps is limited. Thus, we sought to characterize neoplastic GB polyps by analyzing unique EUS features. Our analysis revealed variably shaped, relatively hypoechoic portions in the core of polyps compared with general background echogenicity. Objective: Our purpose was to make a differential diagnosis between neoplastic and nonneoplastic GB polyps of less than 20 mm by use of EUS variables, including hypoechoic foci. Design: Retrospective single-center study. Setting: University teaching hospital. Patients: Patients (n = 88) underwent preoperative EUS and cholecystectomy for GB polyps smaller than 20 mm. Results: Hypoechoic foci were found in 30 of 33 patients (91%) with neoplastic polyps and 6 of 55 (11%) with nonneoplastic polyps. In a multivariate analysis, hypoechoic foci were the only significant predictive factor for neoplastic polyps (odds ratio [OR] 55.4, 95% CI, 8.26-371, P < .001); the sensitivity and specificity were 90% and 89%, respectively. In addition, polyps >15 mm had an increased risk of malignancy (OR 21.7, 95% CI, 2.35-201, P = .007), as did those with hypoechoic foci (OR 10.9; 95% CI, 1.01-117, P = .049). Limitations: Retrospective review of selected patients from a tertiary medical center. Conclusions: The presence of hypoechoic foci on EUS is a strong predictive factor for neoplastic polyps. EUS may be useful in developing a treatment strategy for GB polyps.

UR - http://www.scopus.com/inward/record.url?scp=66049132532&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=66049132532&partnerID=8YFLogxK

U2 - 10.1016/j.gie.2008.10.017

DO - 10.1016/j.gie.2008.10.017

M3 - Article

C2 - 19249773

AN - SCOPUS:66049132532

VL - 69

SP - 1244

EP - 1250

JO - Gastrointestinal Endoscopy

JF - Gastrointestinal Endoscopy

SN - 0016-5107

IS - 7

ER -