Hypothalamic AMPK as a Regulator of Energy Homeostasis

My Khanh Q. Huynh, Ann W. Kinyua, Dong Joo Yang, Ki Woo Kim

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Activated in energy depletion conditions, AMP-activated protein kinase (AMPK) acts as a cellular energy sensor and regulator in both central nervous system and peripheral organs. Hypothalamic AMPK restores energy balance by promoting feeding behavior to increase energy intake, increasing glucose production, and reducing thermogenesis to decrease energy output. Besides energy state, many hormones have been shown to act in concert with AMPK to mediate their anorexigenic and orexigenic central effects as well as thermogenic influences. Here we explore the factors that affect hypothalamic AMPK activity and give the underlying mechanisms for the role of central AMPK in energy homeostasis together with the physiological effects of hypothalamic AMPK on energy balance restoration.

Original languageEnglish
Article number2754078
JournalNeural Plasticity
Volume2016
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

AMP-Activated Protein Kinases
Homeostasis
Thermogenesis
Feeding Behavior
Energy Intake
Central Nervous System
Hormones
Glucose

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Huynh, My Khanh Q. ; Kinyua, Ann W. ; Yang, Dong Joo ; Kim, Ki Woo. / Hypothalamic AMPK as a Regulator of Energy Homeostasis. In: Neural Plasticity. 2016 ; Vol. 2016.
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Hypothalamic AMPK as a Regulator of Energy Homeostasis. / Huynh, My Khanh Q.; Kinyua, Ann W.; Yang, Dong Joo; Kim, Ki Woo.

In: Neural Plasticity, Vol. 2016, 2754078, 01.01.2016.

Research output: Contribution to journalReview article

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