Hypothalamic inflammation and obesity: a mechanistic review

Jichang Seong, Jung Yun Kang, Ji Su Sun, Ki Woo Kim

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Obesity is one of the worldwide prevalent disease caused by the imbalance between food intake and energy expenditure. Over a 100 years of research demonstrate that hypothalamus is the critical brain region regulating energy homeostasis, and evidences suggest the participation of non-neuronal populations such as astrocytes and microglia in the regulation of energy homeostasis. Recently, fat-rich diet induced hypothalamic inflammation has been found to deregulate the energy homeostasis, leading to the insulin resistance, glucose intolerance, and obesity. Several underlying mechanisms have been proposed, yet compelling evidences require further elucidations. This review discusses the up to date proposed mechanisms by which fat-rich diet induces hypothalamic inflammation and obesity.

Original languageEnglish
Pages (from-to)383-392
Number of pages10
JournalArchives of pharmacal research
Volume42
Issue number5
DOIs
Publication statusPublished - 2019 May 1

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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