Hypothalamic lipid-laden astrocytes induce microglia migration and activation

Yoon Hee Kwon, Jiye Kim, Chu Sook Kim, Thai Hien Tu, Min Seon Kim, Kyoungho Suk, Dong Hee Kim, Byung Ju Lee, Hye Seon Choi, Taesun Park, Myung Sook Choi, Tsuyoshi Goto, Teruo Kawada, Tae Youl Ha, Rina Yu

Research output: Contribution to journalLetter

12 Citations (Scopus)

Abstract

Obesity-induced hypothalamic inflammation is closely associated with various metabolic complications and neurodegenerative disorders. Astrocytes, the most abundant glial cells in the central nervous system, play a crucial role in pathological hypothalamic inflammatory processes. Here, we demonstrate that hypothalamic astrocytes accumulate lipid droplets under saturated fatty acid-rich conditions, such as obese environment, and that the lipid-laden astrocytes increase astrogliosis markers and inflammatory cytokines (TNFα, IL-1β, IL-6, MCP-1) at the transcript and/or protein level. Medium conditioned by the lipid-laden astrocytes stimulate microglial chemotactic activity and upregulate transcripts of the microglia activation marker Iba-1 and inflammatory cytokines. These findings indicate that the lipid-laden astrocytes formed in free fatty acid-rich obese condition may participate in obesity-induced hypothalamic inflammation through promoting microglia migration and activation.

Original languageEnglish
Pages (from-to)1742-1751
Number of pages10
JournalFEBS Letters
Volume591
Issue number12
DOIs
Publication statusPublished - 2017 Jun 1

Fingerprint

Microglia
Astrocytes
Chemical activation
Lipids
Obesity
Cytokines
Inflammation
Neurology
Conditioned Culture Medium
Interleukin-1
Nonesterified Fatty Acids
Neuroglia
Neurodegenerative Diseases
Interleukin-6
Up-Regulation
Fatty Acids
Central Nervous System
Proteins

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Kwon, Y. H., Kim, J., Kim, C. S., Tu, T. H., Kim, M. S., Suk, K., ... Yu, R. (2017). Hypothalamic lipid-laden astrocytes induce microglia migration and activation. FEBS Letters, 591(12), 1742-1751. https://doi.org/10.1002/1873-3468.12691
Kwon, Yoon Hee ; Kim, Jiye ; Kim, Chu Sook ; Tu, Thai Hien ; Kim, Min Seon ; Suk, Kyoungho ; Kim, Dong Hee ; Lee, Byung Ju ; Choi, Hye Seon ; Park, Taesun ; Choi, Myung Sook ; Goto, Tsuyoshi ; Kawada, Teruo ; Ha, Tae Youl ; Yu, Rina. / Hypothalamic lipid-laden astrocytes induce microglia migration and activation. In: FEBS Letters. 2017 ; Vol. 591, No. 12. pp. 1742-1751.
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abstract = "Obesity-induced hypothalamic inflammation is closely associated with various metabolic complications and neurodegenerative disorders. Astrocytes, the most abundant glial cells in the central nervous system, play a crucial role in pathological hypothalamic inflammatory processes. Here, we demonstrate that hypothalamic astrocytes accumulate lipid droplets under saturated fatty acid-rich conditions, such as obese environment, and that the lipid-laden astrocytes increase astrogliosis markers and inflammatory cytokines (TNFα, IL-1β, IL-6, MCP-1) at the transcript and/or protein level. Medium conditioned by the lipid-laden astrocytes stimulate microglial chemotactic activity and upregulate transcripts of the microglia activation marker Iba-1 and inflammatory cytokines. These findings indicate that the lipid-laden astrocytes formed in free fatty acid-rich obese condition may participate in obesity-induced hypothalamic inflammation through promoting microglia migration and activation.",
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Kwon, YH, Kim, J, Kim, CS, Tu, TH, Kim, MS, Suk, K, Kim, DH, Lee, BJ, Choi, HS, Park, T, Choi, MS, Goto, T, Kawada, T, Ha, TY & Yu, R 2017, 'Hypothalamic lipid-laden astrocytes induce microglia migration and activation', FEBS Letters, vol. 591, no. 12, pp. 1742-1751. https://doi.org/10.1002/1873-3468.12691

Hypothalamic lipid-laden astrocytes induce microglia migration and activation. / Kwon, Yoon Hee; Kim, Jiye; Kim, Chu Sook; Tu, Thai Hien; Kim, Min Seon; Suk, Kyoungho; Kim, Dong Hee; Lee, Byung Ju; Choi, Hye Seon; Park, Taesun; Choi, Myung Sook; Goto, Tsuyoshi; Kawada, Teruo; Ha, Tae Youl; Yu, Rina.

In: FEBS Letters, Vol. 591, No. 12, 01.06.2017, p. 1742-1751.

Research output: Contribution to journalLetter

TY - JOUR

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AU - Kwon, Yoon Hee

AU - Kim, Jiye

AU - Kim, Chu Sook

AU - Tu, Thai Hien

AU - Kim, Min Seon

AU - Suk, Kyoungho

AU - Kim, Dong Hee

AU - Lee, Byung Ju

AU - Choi, Hye Seon

AU - Park, Taesun

AU - Choi, Myung Sook

AU - Goto, Tsuyoshi

AU - Kawada, Teruo

AU - Ha, Tae Youl

AU - Yu, Rina

PY - 2017/6/1

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N2 - Obesity-induced hypothalamic inflammation is closely associated with various metabolic complications and neurodegenerative disorders. Astrocytes, the most abundant glial cells in the central nervous system, play a crucial role in pathological hypothalamic inflammatory processes. Here, we demonstrate that hypothalamic astrocytes accumulate lipid droplets under saturated fatty acid-rich conditions, such as obese environment, and that the lipid-laden astrocytes increase astrogliosis markers and inflammatory cytokines (TNFα, IL-1β, IL-6, MCP-1) at the transcript and/or protein level. Medium conditioned by the lipid-laden astrocytes stimulate microglial chemotactic activity and upregulate transcripts of the microglia activation marker Iba-1 and inflammatory cytokines. These findings indicate that the lipid-laden astrocytes formed in free fatty acid-rich obese condition may participate in obesity-induced hypothalamic inflammation through promoting microglia migration and activation.

AB - Obesity-induced hypothalamic inflammation is closely associated with various metabolic complications and neurodegenerative disorders. Astrocytes, the most abundant glial cells in the central nervous system, play a crucial role in pathological hypothalamic inflammatory processes. Here, we demonstrate that hypothalamic astrocytes accumulate lipid droplets under saturated fatty acid-rich conditions, such as obese environment, and that the lipid-laden astrocytes increase astrogliosis markers and inflammatory cytokines (TNFα, IL-1β, IL-6, MCP-1) at the transcript and/or protein level. Medium conditioned by the lipid-laden astrocytes stimulate microglial chemotactic activity and upregulate transcripts of the microglia activation marker Iba-1 and inflammatory cytokines. These findings indicate that the lipid-laden astrocytes formed in free fatty acid-rich obese condition may participate in obesity-induced hypothalamic inflammation through promoting microglia migration and activation.

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Kwon YH, Kim J, Kim CS, Tu TH, Kim MS, Suk K et al. Hypothalamic lipid-laden astrocytes induce microglia migration and activation. FEBS Letters. 2017 Jun 1;591(12):1742-1751. https://doi.org/10.1002/1873-3468.12691