Hypoxia-specific VEGF-expressing neural stem cells in spinal cord injury model

Jin Soo Oh, Sung Su An, So Jung Gwak, William A. Pennant, Keung Nyun Kim, Do Heum Yoon, Yoon Ha

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We established three stable neural stem cell (NSC) lines to explore the possibility of using hypoxia-specific vascular endothelial growth factor (VEGF) expressing NSC lines (EpoSV-VEGF NSCs) to treat spinal cord injury. The application of EpoSV-VEGF NSCs into the injured spinal cord after clip compression injury not only showed therapeutic effects such as extended survival and angiogenesis, but also displayed its safety profile as it did not cause unwanted cell proliferation or angiogenesis in normal spinal cord tissue, as EpoSV-VEGF NSCs consistently showed hypoxia-specific VEGF expression patterns. This suggests that our EpoSV-VEGF NSCs are both safe and therapeutically efficacious for the treatment of spinal cord injury. Furthermore, this hypoxia-inducible gene expression system may represent a safe tool suitable for gene therapy.

Original languageEnglish
Pages (from-to)174-178
Number of pages5
JournalNeuroReport
Volume23
Issue number3
DOIs
Publication statusPublished - 2012 Feb 15

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Neural Stem Cells
Spinal Cord Injuries
Vascular Endothelial Growth Factor A
Spinal Cord
Cell Line
Therapeutic Uses
Surgical Instruments
Genetic Therapy
Hypoxia
Cell Proliferation
Safety
Gene Expression
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Oh, J. S., An, S. S., Gwak, S. J., Pennant, W. A., Kim, K. N., Yoon, D. H., & Ha, Y. (2012). Hypoxia-specific VEGF-expressing neural stem cells in spinal cord injury model. NeuroReport, 23(3), 174-178. https://doi.org/10.1097/WNR.0b013e32834f4f3a
Oh, Jin Soo ; An, Sung Su ; Gwak, So Jung ; Pennant, William A. ; Kim, Keung Nyun ; Yoon, Do Heum ; Ha, Yoon. / Hypoxia-specific VEGF-expressing neural stem cells in spinal cord injury model. In: NeuroReport. 2012 ; Vol. 23, No. 3. pp. 174-178.
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Oh, JS, An, SS, Gwak, SJ, Pennant, WA, Kim, KN, Yoon, DH & Ha, Y 2012, 'Hypoxia-specific VEGF-expressing neural stem cells in spinal cord injury model', NeuroReport, vol. 23, no. 3, pp. 174-178. https://doi.org/10.1097/WNR.0b013e32834f4f3a

Hypoxia-specific VEGF-expressing neural stem cells in spinal cord injury model. / Oh, Jin Soo; An, Sung Su; Gwak, So Jung; Pennant, William A.; Kim, Keung Nyun; Yoon, Do Heum; Ha, Yoon.

In: NeuroReport, Vol. 23, No. 3, 15.02.2012, p. 174-178.

Research output: Contribution to journalArticle

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Oh JS, An SS, Gwak SJ, Pennant WA, Kim KN, Yoon DH et al. Hypoxia-specific VEGF-expressing neural stem cells in spinal cord injury model. NeuroReport. 2012 Feb 15;23(3):174-178. https://doi.org/10.1097/WNR.0b013e32834f4f3a