Prostate cancer has heterogeneous characteristics. For that reason, even if tumors appear histologically similar to each other, there are many cases in which they are actually different, based on their gene expression levels. A single tumor may have multiple expression levels with both high-risk cancer genes and low-risk cancer genes. We can produce more useful models for stratifying prostate cancers into high-risk cancer and low-risk cancer categories by considering the range in each class through inner-class clustering. In this paper, we attempt to classify cancers into high-risk (aggressive) prostate cancer and low-risk (non-aggressive) prostate cancer using ICP (Inner-class Clustering and Prediction). Our model classified more efficiently than the models of the algorithms used for comparison. After discovering a number of genes linked to prostate cancer from the gene pairs used in our classification, we discovered that the proposed method can be used to find new unknown genes and gene pairs which distinguish between high-risk cancer and low-risk cancer.
Bibliographical noteFunding Information:
Funding: This work was supported by National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (No. 2012010775 ), and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( 20120002887 ).
All Science Journal Classification (ASJC) codes
- Computer Science Applications
- Health Informatics