Ictal electrocorticographic findings related with surgical outcomes in nonlesional neocortical epilepsy

S. A. Park, S. R. Lim, G. S. Kim, K. Heo, S. C. Park, JinWoo Chang, S. S. Chung, J. U. Choi, T. S. Kim, Byung In Lee

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Abstract

Purpose: To characterize ictal electrocorticographic features related to surgical outcomes in nonlesional neocortical epilepsy (NE). Methods: We analyzed 187 ictal electrocorticograms (ECoG) obtained from 18 patients who had undergone presurgical evaluation and subsequent neocortical resections (frontal: seven, parietal: one, occipital: four, multilobar: six). None of them had any MRI-detectable lesions. Various ECoG data sets recorded from eight patients who achieved a favorable surgical outcome (either seizure free or more than 90% reduction of seizure frequencies) were compared with that from ten patients with unfavorable outcome (less than 90% reduction of seizure frequencies) (follow up duration: 47 ± 11 months). Results: Reproducible ictal onset zone (IOZ) in recurrent seizures (P = 0.013) and persistent ictal discharges in IOZ from the onset to the end of seizure (P = 0.004) were found more frequently in the patients with good outcome. Ictal onset patterns consisting of low voltage fast or high amplitude beta spikes predicted a good surgical outcome while rhythmic sinusoidal activity or rhythmic spike/sharp waves of slow frequency were predictive of poor outcome (P = 0.01). The ictal onset rhythm consisting of gamma or beta frequencies was more prevalent in the favorable group (P = 0.015). Conclusions: The presence of stable ictal circuit suggested by the consistent earliest activation of specific electrodes in the repetitive seizures (reproducible IOZ) and the active participation of IOZ throughout the attack were valuable prognostic factors in addition to the morphology and frequency of ictal onset rhythm.

Original languageEnglish
Pages (from-to)199-206
Number of pages8
JournalEpilepsy Research
Volume48
Issue number3
DOIs
Publication statusPublished - 2002 Apr 6

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Epilepsy
Stroke
Seizures
Beta Rhythm
Electrodes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Park, S. A. ; Lim, S. R. ; Kim, G. S. ; Heo, K. ; Park, S. C. ; Chang, JinWoo ; Chung, S. S. ; Choi, J. U. ; Kim, T. S. ; Lee, Byung In. / Ictal electrocorticographic findings related with surgical outcomes in nonlesional neocortical epilepsy. In: Epilepsy Research. 2002 ; Vol. 48, No. 3. pp. 199-206.
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abstract = "Purpose: To characterize ictal electrocorticographic features related to surgical outcomes in nonlesional neocortical epilepsy (NE). Methods: We analyzed 187 ictal electrocorticograms (ECoG) obtained from 18 patients who had undergone presurgical evaluation and subsequent neocortical resections (frontal: seven, parietal: one, occipital: four, multilobar: six). None of them had any MRI-detectable lesions. Various ECoG data sets recorded from eight patients who achieved a favorable surgical outcome (either seizure free or more than 90{\%} reduction of seizure frequencies) were compared with that from ten patients with unfavorable outcome (less than 90{\%} reduction of seizure frequencies) (follow up duration: 47 ± 11 months). Results: Reproducible ictal onset zone (IOZ) in recurrent seizures (P = 0.013) and persistent ictal discharges in IOZ from the onset to the end of seizure (P = 0.004) were found more frequently in the patients with good outcome. Ictal onset patterns consisting of low voltage fast or high amplitude beta spikes predicted a good surgical outcome while rhythmic sinusoidal activity or rhythmic spike/sharp waves of slow frequency were predictive of poor outcome (P = 0.01). The ictal onset rhythm consisting of gamma or beta frequencies was more prevalent in the favorable group (P = 0.015). Conclusions: The presence of stable ictal circuit suggested by the consistent earliest activation of specific electrodes in the repetitive seizures (reproducible IOZ) and the active participation of IOZ throughout the attack were valuable prognostic factors in addition to the morphology and frequency of ictal onset rhythm.",
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Park, SA, Lim, SR, Kim, GS, Heo, K, Park, SC, Chang, J, Chung, SS, Choi, JU, Kim, TS & Lee, BI 2002, 'Ictal electrocorticographic findings related with surgical outcomes in nonlesional neocortical epilepsy', Epilepsy Research, vol. 48, no. 3, pp. 199-206. https://doi.org/10.1016/S0920-1211(02)00006-2

Ictal electrocorticographic findings related with surgical outcomes in nonlesional neocortical epilepsy. / Park, S. A.; Lim, S. R.; Kim, G. S.; Heo, K.; Park, S. C.; Chang, JinWoo; Chung, S. S.; Choi, J. U.; Kim, T. S.; Lee, Byung In.

In: Epilepsy Research, Vol. 48, No. 3, 06.04.2002, p. 199-206.

Research output: Contribution to journalArticle

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T1 - Ictal electrocorticographic findings related with surgical outcomes in nonlesional neocortical epilepsy

AU - Park, S. A.

AU - Lim, S. R.

AU - Kim, G. S.

AU - Heo, K.

AU - Park, S. C.

AU - Chang, JinWoo

AU - Chung, S. S.

AU - Choi, J. U.

AU - Kim, T. S.

AU - Lee, Byung In

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N2 - Purpose: To characterize ictal electrocorticographic features related to surgical outcomes in nonlesional neocortical epilepsy (NE). Methods: We analyzed 187 ictal electrocorticograms (ECoG) obtained from 18 patients who had undergone presurgical evaluation and subsequent neocortical resections (frontal: seven, parietal: one, occipital: four, multilobar: six). None of them had any MRI-detectable lesions. Various ECoG data sets recorded from eight patients who achieved a favorable surgical outcome (either seizure free or more than 90% reduction of seizure frequencies) were compared with that from ten patients with unfavorable outcome (less than 90% reduction of seizure frequencies) (follow up duration: 47 ± 11 months). Results: Reproducible ictal onset zone (IOZ) in recurrent seizures (P = 0.013) and persistent ictal discharges in IOZ from the onset to the end of seizure (P = 0.004) were found more frequently in the patients with good outcome. Ictal onset patterns consisting of low voltage fast or high amplitude beta spikes predicted a good surgical outcome while rhythmic sinusoidal activity or rhythmic spike/sharp waves of slow frequency were predictive of poor outcome (P = 0.01). The ictal onset rhythm consisting of gamma or beta frequencies was more prevalent in the favorable group (P = 0.015). Conclusions: The presence of stable ictal circuit suggested by the consistent earliest activation of specific electrodes in the repetitive seizures (reproducible IOZ) and the active participation of IOZ throughout the attack were valuable prognostic factors in addition to the morphology and frequency of ictal onset rhythm.

AB - Purpose: To characterize ictal electrocorticographic features related to surgical outcomes in nonlesional neocortical epilepsy (NE). Methods: We analyzed 187 ictal electrocorticograms (ECoG) obtained from 18 patients who had undergone presurgical evaluation and subsequent neocortical resections (frontal: seven, parietal: one, occipital: four, multilobar: six). None of them had any MRI-detectable lesions. Various ECoG data sets recorded from eight patients who achieved a favorable surgical outcome (either seizure free or more than 90% reduction of seizure frequencies) were compared with that from ten patients with unfavorable outcome (less than 90% reduction of seizure frequencies) (follow up duration: 47 ± 11 months). Results: Reproducible ictal onset zone (IOZ) in recurrent seizures (P = 0.013) and persistent ictal discharges in IOZ from the onset to the end of seizure (P = 0.004) were found more frequently in the patients with good outcome. Ictal onset patterns consisting of low voltage fast or high amplitude beta spikes predicted a good surgical outcome while rhythmic sinusoidal activity or rhythmic spike/sharp waves of slow frequency were predictive of poor outcome (P = 0.01). The ictal onset rhythm consisting of gamma or beta frequencies was more prevalent in the favorable group (P = 0.015). Conclusions: The presence of stable ictal circuit suggested by the consistent earliest activation of specific electrodes in the repetitive seizures (reproducible IOZ) and the active participation of IOZ throughout the attack were valuable prognostic factors in addition to the morphology and frequency of ictal onset rhythm.

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