Background/Aim: Long non-coding RNAs (lncRNAs) are emerging as significant regulators of gene expression and a novel promising biomarker for cancer diagnosis and prognosis. This study identified a novel, differentially expressed lncRNA in advanced gastric cancer (AGC), Inc-ATMIN-4:2, and evaluated its clinicopathological and prognostic significance. Patients and Methods: Whole transcriptome sequencing was performed to identify differentially expressed lncRNAs in AGC tissue samples. We also analyzed lnc-ATMIN-4:2 expression in 317 patients with AGC using RNA in situ hybridization. Results: High (>30 dots) lnc-ATMIN-4:2 expression significantly correlated with younger age, poorly differentiated histology, diffuse type, deeper invasion depth, perineural invasion, lymph node metastasis, and higher stage group. In addition, high lnc- ATMIN-4:2 expression was significantly associated with worse overall survival in patients with AGC. Conclusion: This study elucidated the significance of lncRNAs in AGC and indicated the value of lnc-ATMIN-4:2 expression as a predictive biomarker for the overall survival of patients with AGC.
|Number of pages||12|
|Journal||Cancer Genomics and Proteomics|
|Publication status||Published - 2022 Nov|
Bibliographical noteFunding Information:
This research was supported by the Bio and Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) (2019M3E5D1A02068558) and a grant of the Korea health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by Ministry of Health & Welfare, Republic of Korea (HR20C0025).
© 2022 International Institute of Anticancer Research. All rights reserved.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cancer Research