Abstract
Objective: The aim of this study was to identify the clinical baseline factors that affect the long-term treatment failure of benign prostatic hyperplasia (BPH). Methods: 437 men over 50 years of age with BPH were enrolled for this analysis. Patients were allocated to a medication and a surgical treatment (following medication) group. We initially examined the International Prostatic Symptom Score (IPSS), uroflow rate, prostate volume, postvoid residual volume, and the serum prostate specific antigen level as clinical baseline factors and analyzed differences between the two groups. Results: 337 patients (77.1%) were given maintenance medical treatment during follow-up, and 100 patients (22.9%) had surgical treatment following medication. Statistically significant differences were found in IPSS and prostate volume between the surgical and medication groups (IPSS: 22.6 ± 6.4 vs. 18.7 ± 5.8, prostate volume (cm3): 36.3 ± 14.4 vs. 30.1 ± 11.0, respectively). According to the ROC curve-based prediction of the failure for medical therapy, the best cutoff values of IPSS and prostate volume were 21 (area under ROC curve: 0.67) and 32 cm3 (area under ROC curve: 0.65), respectively. Conclusions: The results show that BPH patients with more severe IPSS and larger prostate volume have a higher risk of medical treatment failure, and suggest that the IPSS and prostate volume may be useful predictors of medical treatment maintenance.
| Original language | English |
|---|---|
| Pages (from-to) | 94-100 |
| Number of pages | 7 |
| Journal | European Urology |
| Volume | 44 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2003 Jul 1 |
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All Science Journal Classification (ASJC) codes
- Urology
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Identification of baseline clinical factors which predict medical treatment failure of benign prostatic hyperplasia : An observational cohort study. / Hong, Sung Joon; Ko, Woo Jin; Kim, Sun Il; Chung, Byungha; Djavan, B.
In: European Urology, Vol. 44, No. 1, 01.07.2003, p. 94-100.Research output: Contribution to journal › Article
TY - JOUR
T1 - Identification of baseline clinical factors which predict medical treatment failure of benign prostatic hyperplasia
T2 - An observational cohort study
AU - Hong, Sung Joon
AU - Ko, Woo Jin
AU - Kim, Sun Il
AU - Chung, Byungha
AU - Djavan, B.
PY - 2003/7/1
Y1 - 2003/7/1
N2 - Objective: The aim of this study was to identify the clinical baseline factors that affect the long-term treatment failure of benign prostatic hyperplasia (BPH). Methods: 437 men over 50 years of age with BPH were enrolled for this analysis. Patients were allocated to a medication and a surgical treatment (following medication) group. We initially examined the International Prostatic Symptom Score (IPSS), uroflow rate, prostate volume, postvoid residual volume, and the serum prostate specific antigen level as clinical baseline factors and analyzed differences between the two groups. Results: 337 patients (77.1%) were given maintenance medical treatment during follow-up, and 100 patients (22.9%) had surgical treatment following medication. Statistically significant differences were found in IPSS and prostate volume between the surgical and medication groups (IPSS: 22.6 ± 6.4 vs. 18.7 ± 5.8, prostate volume (cm3): 36.3 ± 14.4 vs. 30.1 ± 11.0, respectively). According to the ROC curve-based prediction of the failure for medical therapy, the best cutoff values of IPSS and prostate volume were 21 (area under ROC curve: 0.67) and 32 cm3 (area under ROC curve: 0.65), respectively. Conclusions: The results show that BPH patients with more severe IPSS and larger prostate volume have a higher risk of medical treatment failure, and suggest that the IPSS and prostate volume may be useful predictors of medical treatment maintenance.
AB - Objective: The aim of this study was to identify the clinical baseline factors that affect the long-term treatment failure of benign prostatic hyperplasia (BPH). Methods: 437 men over 50 years of age with BPH were enrolled for this analysis. Patients were allocated to a medication and a surgical treatment (following medication) group. We initially examined the International Prostatic Symptom Score (IPSS), uroflow rate, prostate volume, postvoid residual volume, and the serum prostate specific antigen level as clinical baseline factors and analyzed differences between the two groups. Results: 337 patients (77.1%) were given maintenance medical treatment during follow-up, and 100 patients (22.9%) had surgical treatment following medication. Statistically significant differences were found in IPSS and prostate volume between the surgical and medication groups (IPSS: 22.6 ± 6.4 vs. 18.7 ± 5.8, prostate volume (cm3): 36.3 ± 14.4 vs. 30.1 ± 11.0, respectively). According to the ROC curve-based prediction of the failure for medical therapy, the best cutoff values of IPSS and prostate volume were 21 (area under ROC curve: 0.67) and 32 cm3 (area under ROC curve: 0.65), respectively. Conclusions: The results show that BPH patients with more severe IPSS and larger prostate volume have a higher risk of medical treatment failure, and suggest that the IPSS and prostate volume may be useful predictors of medical treatment maintenance.
UR - http://www.scopus.com/inward/record.url?scp=0037974440&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037974440&partnerID=8YFLogxK
U2 - 10.1016/S0302-2838(03)00199-4
DO - 10.1016/S0302-2838(03)00199-4
M3 - Article
C2 - 12814681
AN - SCOPUS:0037974440
VL - 44
SP - 94
EP - 100
JO - European Urology
JF - European Urology
SN - 0302-2838
IS - 1
ER -