Abstract
Four oligomeric procyanidins were isolated from the MeOH extracts of the leaves of Crataegus pinnatifida (Rosaceae). Investigation of collagenase and gelatinase inhibitory natural components afforded four oligomeric procyanidins. Of these, 2 and 3 exhibited collagenase inhibitory activity (IC50) at a concentration of less than 1 μM, and 3 showed gelatinases A and B inhibitory activity (IC50) at 0.4 and 2.3 μM, respectively.
Original language | English |
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Pages (from-to) | 991-993 |
Number of pages | 3 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 20 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2010 Feb 1 |
Bibliographical note
Funding Information:This study was supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea . ( A080320 )
All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry