Abstract
Four oligomeric procyanidins were isolated from the MeOH extracts of the leaves of Crataegus pinnatifida (Rosaceae). Investigation of collagenase and gelatinase inhibitory natural components afforded four oligomeric procyanidins. Of these, 2 and 3 exhibited collagenase inhibitory activity (IC50) at a concentration of less than 1 μM, and 3 showed gelatinases A and B inhibitory activity (IC50) at 0.4 and 2.3 μM, respectively.
| Original language | English |
|---|---|
| Pages (from-to) | 991-993 |
| Number of pages | 3 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 20 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2010 Feb 1 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
Cite this
}
Identification of potential and selective collagenase, gelatinase inhibitors from Crataegus pinnatifida. / Moon, Hyung In; Kim, Tae-im; Cho, Hyun Soo; Kim, Eungkweon.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 20, No. 3, 01.02.2010, p. 991-993.Research output: Contribution to journal › Article
TY - JOUR
T1 - Identification of potential and selective collagenase, gelatinase inhibitors from Crataegus pinnatifida
AU - Moon, Hyung In
AU - Kim, Tae-im
AU - Cho, Hyun Soo
AU - Kim, Eungkweon
PY - 2010/2/1
Y1 - 2010/2/1
N2 - Four oligomeric procyanidins were isolated from the MeOH extracts of the leaves of Crataegus pinnatifida (Rosaceae). Investigation of collagenase and gelatinase inhibitory natural components afforded four oligomeric procyanidins. Of these, 2 and 3 exhibited collagenase inhibitory activity (IC50) at a concentration of less than 1 μM, and 3 showed gelatinases A and B inhibitory activity (IC50) at 0.4 and 2.3 μM, respectively.
AB - Four oligomeric procyanidins were isolated from the MeOH extracts of the leaves of Crataegus pinnatifida (Rosaceae). Investigation of collagenase and gelatinase inhibitory natural components afforded four oligomeric procyanidins. Of these, 2 and 3 exhibited collagenase inhibitory activity (IC50) at a concentration of less than 1 μM, and 3 showed gelatinases A and B inhibitory activity (IC50) at 0.4 and 2.3 μM, respectively.
UR - http://www.scopus.com/inward/record.url?scp=74349087162&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=74349087162&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2009.12.059
DO - 10.1016/j.bmcl.2009.12.059
M3 - Article
C2 - 20053563
AN - SCOPUS:74349087162
VL - 20
SP - 991
EP - 993
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 3
ER -