Identification of potential and selective collagenase, gelatinase inhibitors from Crataegus pinnatifida

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Four oligomeric procyanidins were isolated from the MeOH extracts of the leaves of Crataegus pinnatifida (Rosaceae). Investigation of collagenase and gelatinase inhibitory natural components afforded four oligomeric procyanidins. Of these, 2 and 3 exhibited collagenase inhibitory activity (IC50) at a concentration of less than 1 μM, and 3 showed gelatinases A and B inhibitory activity (IC50) at 0.4 and 2.3 μM, respectively.

Original languageEnglish
Pages (from-to)991-993
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Issue number3
Publication statusPublished - 2010 Feb 1


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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