Identification of potential and selective collagenase, gelatinase inhibitors from Crataegus pinnatifida

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Abstract

Four oligomeric procyanidins were isolated from the MeOH extracts of the leaves of Crataegus pinnatifida (Rosaceae). Investigation of collagenase and gelatinase inhibitory natural components afforded four oligomeric procyanidins. Of these, 2 and 3 exhibited collagenase inhibitory activity (IC50) at a concentration of less than 1 μM, and 3 showed gelatinases A and B inhibitory activity (IC50) at 0.4 and 2.3 μM, respectively.

Original languageEnglish
Pages (from-to)991-993
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number3
DOIs
Publication statusPublished - 2010 Feb 1

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Crataegus
Proanthocyanidins
Matrix Metalloproteinase Inhibitors
Collagenases
Inhibitory Concentration 50
Rosaceae
Matrix Metalloproteinase 13
Gelatinases
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

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abstract = "Four oligomeric procyanidins were isolated from the MeOH extracts of the leaves of Crataegus pinnatifida (Rosaceae). Investigation of collagenase and gelatinase inhibitory natural components afforded four oligomeric procyanidins. Of these, 2 and 3 exhibited collagenase inhibitory activity (IC50) at a concentration of less than 1 μM, and 3 showed gelatinases A and B inhibitory activity (IC50) at 0.4 and 2.3 μM, respectively.",
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AU - Moon, Hyung In

AU - Kim, Tae-im

AU - Cho, Hyun Soo

AU - Kim, Eungkweon

PY - 2010/2/1

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AB - Four oligomeric procyanidins were isolated from the MeOH extracts of the leaves of Crataegus pinnatifida (Rosaceae). Investigation of collagenase and gelatinase inhibitory natural components afforded four oligomeric procyanidins. Of these, 2 and 3 exhibited collagenase inhibitory activity (IC50) at a concentration of less than 1 μM, and 3 showed gelatinases A and B inhibitory activity (IC50) at 0.4 and 2.3 μM, respectively.

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