Identification of potential and selective collagenase, gelatinase inhibitors from Crataegus pinnatifida

Hyung In Moon; Tae im Kim; Hyun Soo Cho; Eung Kweon Kim

doi:10.1016/j.bmcl.2009.12.059

Identification of potential and selective collagenase, gelatinase inhibitors from Crataegus pinnatifida

Hyung In Moon, Tae im Kim, Hyun Soo Cho, Eung Kweon Kim

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Four oligomeric procyanidins were isolated from the MeOH extracts of the leaves of Crataegus pinnatifida (Rosaceae). Investigation of collagenase and gelatinase inhibitory natural components afforded four oligomeric procyanidins. Of these, 2 and 3 exhibited collagenase inhibitory activity (IC₅₀) at a concentration of less than 1 μM, and 3 showed gelatinases A and B inhibitory activity (IC₅₀) at 0.4 and 2.3 μM, respectively.

Original language	English
Pages (from-to)	991-993
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/j.bmcl.2009.12.059
Publication status	Published - 2010 Feb 1

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea . ( A080320 )

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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title = "Identification of potential and selective collagenase, gelatinase inhibitors from Crataegus pinnatifida",

abstract = "Four oligomeric procyanidins were isolated from the MeOH extracts of the leaves of Crataegus pinnatifida (Rosaceae). Investigation of collagenase and gelatinase inhibitory natural components afforded four oligomeric procyanidins. Of these, 2 and 3 exhibited collagenase inhibitory activity (IC50) at a concentration of less than 1 μM, and 3 showed gelatinases A and B inhibitory activity (IC50) at 0.4 and 2.3 μM, respectively.",

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AU - Kim, Tae im

AU - Cho, Hyun Soo

AU - Kim, Eung Kweon

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