Identification of tumor necrosis factor signaling-related proteins during Epstein-Barr virus-induced B cell transformation

J. P. Jeon, J. W. Kim, B. Park, H. Y. Nam, S. M. Shim, M. H. Lee, B. G. Han

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Abstract

Epstein-Barr virus (EBV) infection in vitro transforms primary B cells into continuously proliferating lymphoblastoid cell lines (LCLs) that have been widely used as a genomic resource for variety of immunological and genetic studies. However, the biochemical and biological characteristics that distinguish LCLs from the B cells have not been thoroughly investigated. Our proteomic approach showed that EBV infection induced changes in the profiles of tumor necrosis factor (TNF) signaling-related proteins in LCLs including heat shock protein family members TNF receptor-associated protein 1 (TRAP-1), heat shock 70-kDa protein 9 (HSPA9)) and superoxide dismutase 2 (SOD2). In addition, our literature co-occurrence study placed TNF at the center of a gene cluster network of differentially expressed proteins in LCLs. This study suggested that deregulation of TNF signaling pathway could contribute to the cellular transformation and immortalization of the EBV-infected B cells.

Original languageEnglish
Pages (from-to)151-159
Number of pages9
JournalActa Virologica
Volume52
Issue number3
Publication statusPublished - 2008 Oct 27

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All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

Cite this

Jeon, J. P., Kim, J. W., Park, B., Nam, H. Y., Shim, S. M., Lee, M. H., & Han, B. G. (2008). Identification of tumor necrosis factor signaling-related proteins during Epstein-Barr virus-induced B cell transformation. Acta Virologica, 52(3), 151-159.