Identifying liver cancer and its relations with diseases, drugs, and genes

A literature-based approach

Yongjun Zhu, Min Song, Erjia Yan

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In biomedicine, scientific literature is a valuable source for knowledge discovery. Mining knowledge from textual data has become an ever important task as the volume of scientific literature is growing unprecedentedly. In this paper, we propose a framework for examining a certain disease based on existing information provided by scientific literature. Disease-related entities that include diseases, drugs, and genes are systematically extracted and analyzed using a three-level network-based approach. A paper-entity network and an entity co-occurrence network (macro-level) are explored and used to construct six entity specific networks (meso-level). Important diseases, drugs, and genes as well as salient entity relations (micro-level) are identified from these networks. Results obtained from the literature-based literature mining can serve to assist clinical applications.

Original languageEnglish
Article numbere0156091
JournalPloS one
Volume11
Issue number5
DOIs
Publication statusPublished - 2016 May 1

Fingerprint

liver neoplasms
Liver Neoplasms
Literature
Liver
Genes
drugs
Pharmaceutical Preparations
genes
Data mining
Macros

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

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Identifying liver cancer and its relations with diseases, drugs, and genes : A literature-based approach. / Zhu, Yongjun; Song, Min; Yan, Erjia.

In: PloS one, Vol. 11, No. 5, e0156091, 01.05.2016.

Research output: Contribution to journalArticle

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