Identifying liver cancer and its relations with diseases, drugs, and genes: A literature-based approach

Yongjun Zhu, Min Song, Erjia Yan

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


In biomedicine, scientific literature is a valuable source for knowledge discovery. Mining knowledge from textual data has become an ever important task as the volume of scientific literature is growing unprecedentedly. In this paper, we propose a framework for examining a certain disease based on existing information provided by scientific literature. Disease-related entities that include diseases, drugs, and genes are systematically extracted and analyzed using a three-level network-based approach. A paper-entity network and an entity co-occurrence network (macro-level) are explored and used to construct six entity specific networks (meso-level). Important diseases, drugs, and genes as well as salient entity relations (micro-level) are identified from these networks. Results obtained from the literature-based literature mining can serve to assist clinical applications.

Original languageEnglish
Article numbere0156091
JournalPloS one
Issue number5
Publication statusPublished - 2016 May 1

Bibliographical note

Funding Information:
This project was made possible in part by the Institute of Museum and Library Services (Grant Award Number: RE-07-15-0060-15), for the project titled "Building an entity-based research framework to enhance digital services on knowledge discovery and delivery". In addition, the project was supported partly by the Bio-Synergy Research Project (NRF-2013M3A9C4078138) of the Ministry of Science, ICT and Future Planning through the National Research Foundation.

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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