Idesolide, an isolate of idesia polycarpa, inhibits apoptosis through induction of intracellular heat shock protein 70 in C2C12 muscle cells

Min Ho Jung, Jung Min Yoo, Yeo Jin Kang, Hyoung Woo Lee, Seung Hyun Kim, Sang Hyun Sung, Yong Jin Lee, Inho Choi, Tack Joong Kim

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Muscle disorders, such as muscular dystrophy, are associated with an increase in oxidative stress. Proposed treatments for muscular dystrophy, some in clinical trials, include gene therapy and muscle cell transplantation. In this study, we investigated the effects of idesolide, isolated from the fruits of Idesia polycarpa, on changes that occur in muscle disuse atrophy. We noted protective effects on oxidative stress response and HSP70 regulation. Pre-treatment with idesolide for 24 h maintained cell viability and decreased apoptosis in H2O2-treated C2C12muscle cells. The idesolide pretreatment also increased intracellular HSP70 protein. Our results suggest that idesolide inhibits cell death through induction of HSP70 in C2C12muscle cells. This work is the first to report that idesolide can regulate the decrease in HSP70 that occurs during skeletal muscle atrophy.

Original languageEnglish
Pages (from-to)1063-1066
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume33
Issue number6
DOIs
Publication statusPublished - 2010 Jun 17

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HSP70 Heat-Shock Proteins
Muscle Cells
Apoptosis
Muscular Atrophy
Muscular Dystrophies
Oxidative Stress
Atrophic Muscular Disorders
Cell Transplantation
Muscular Diseases
Genetic Therapy
Fruit
Cell Survival
Skeletal Muscle
Cell Death
idesolide
Clinical Trials
Therapeutics
Proteins

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

Jung, Min Ho ; Yoo, Jung Min ; Kang, Yeo Jin ; Lee, Hyoung Woo ; Kim, Seung Hyun ; Sung, Sang Hyun ; Lee, Yong Jin ; Choi, Inho ; Kim, Tack Joong. / Idesolide, an isolate of idesia polycarpa, inhibits apoptosis through induction of intracellular heat shock protein 70 in C2C12 muscle cells. In: Biological and Pharmaceutical Bulletin. 2010 ; Vol. 33, No. 6. pp. 1063-1066.
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Idesolide, an isolate of idesia polycarpa, inhibits apoptosis through induction of intracellular heat shock protein 70 in C2C12 muscle cells. / Jung, Min Ho; Yoo, Jung Min; Kang, Yeo Jin; Lee, Hyoung Woo; Kim, Seung Hyun; Sung, Sang Hyun; Lee, Yong Jin; Choi, Inho; Kim, Tack Joong.

In: Biological and Pharmaceutical Bulletin, Vol. 33, No. 6, 17.06.2010, p. 1063-1066.

Research output: Contribution to journalArticle

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AU - Jung, Min Ho

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AU - Kang, Yeo Jin

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AU - Kim, Tack Joong

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