Idesolide, an isolate of idesia polycarpa, inhibits apoptosis through induction of intracellular heat shock protein 70 in C2C12 muscle cells

Min Ho Jung, Jung Min Yoo, Yeo Jin Kang, Hyoung Woo Lee, Seung Hyun Kim, Sang Hyun Sung, Yong Jin Lee, Inho Choi, Tack Joong Kim

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12 Citations (Scopus)

Abstract

Muscle disorders, such as muscular dystrophy, are associated with an increase in oxidative stress. Proposed treatments for muscular dystrophy, some in clinical trials, include gene therapy and muscle cell transplantation. In this study, we investigated the effects of idesolide, isolated from the fruits of Idesia polycarpa, on changes that occur in muscle disuse atrophy. We noted protective effects on oxidative stress response and HSP70 regulation. Pre-treatment with idesolide for 24 h maintained cell viability and decreased apoptosis in H2O2-treated C2C12muscle cells. The idesolide pretreatment also increased intracellular HSP70 protein. Our results suggest that idesolide inhibits cell death through induction of HSP70 in C2C12muscle cells. This work is the first to report that idesolide can regulate the decrease in HSP70 that occurs during skeletal muscle atrophy.

Original languageEnglish
Pages (from-to)1063-1066
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume33
Issue number6
DOIs
Publication statusPublished - 2010 Jun 17

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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