IGF-I of serum and vitreous fluid in patients with diabetic proliferative retinopathy

Hyun Chul Lee, Kwan Woo Lee, Choon Hee Chung, Yoon Suk Chung, Eun Jig Lee, Sung Kil Lim, Kyung Rae Kim, Kap Bum Huh, Sung Chul Lee, Oh Woong Kwon

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Abstract

Vitreous fluid and serum were obtained at the time of vitrectomy from 15 subjects with diabetic proliferative retinopathy and 6 control subjects. The mean serum IGF-I (IGF-I level: 1 nM/l = 7.7 ng/ml) concentrations were 15.40 ± 4.97 nM/l in controls and 16.24 ± 4.32 nM/l in diabetic patients. The mean vitreous IGF-I concentration was 1.05 ± 0.30 nM/l in controls and 0.91 ± 0.50 nM/l in diabetic patients. There were no significant differences between the two groups, and serum IGF-I concentrations were not correlated with vitreous IGF-I concentrations in the patients with diabetic proliferative retinopathy. These data suggest that IGF-I may not be a risk factor for the development of proliferative diabetic retinpathy.

Original languageEnglish
Pages (from-to)85-88
Number of pages4
JournalDiabetes Research and Clinical Practice
Volume24
Issue number2
DOIs
Publication statusPublished - 1994 Jun

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All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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