IL-4 Induced Innate CD8+ T Cells Control Persistent Viral Infection

Ara Lee, Seung Pyo Park, Chan Hee Park, Byung Hyun Kang, Seong Hoe Park, Sang Jun Ha, Kyeong Cheon Jung

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18 Citations (Scopus)


Memory-like CD8+ T cells expressing eomesodermin are a subset of innate T cells initially identified in a number of genetically modified mice, and also exist in wild mice and human. The acquisition of memory phenotype and function by these T cells is dependent on IL–4 produced by PLZF+ innate T cells; however, their physiologic function is still not known. Here we found that these IL-4-induced innate CD8+ T cells are critical for accelerating the control of chronic virus infection. In CIITA-transgenic mice, which have a substantial population of IL-4-induced innate CD8+ T cells, this population facilitated rapid control of viremia and induction of functional anti-viral T-cell responses during infection with chronic form of lymphocytic choriomeningitis virus. Characteristically, anti-viral innate CD8+ T cells accumulated sufficiently during early phase of infection. They produced a robust amount of IFN-γ and TNF-α with enhanced expression of a degranulation marker. Furthermore, this finding was confirmed in wild-type mice. Taken together, the results from our study show that innate CD8+ T cells works as an early defense mechanism against chronic viral infection.

Original languageEnglish
Article numbere1005193
JournalPLoS Pathogens
Issue number10
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Molecular Biology
  • Genetics
  • Virology

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    Lee, A., Park, S. P., Park, C. H., Kang, B. H., Park, S. H., Ha, S. J., & Jung, K. C. (2015). IL-4 Induced Innate CD8+ T Cells Control Persistent Viral Infection. PLoS Pathogens, 11(10), [e1005193].