IL-4 Induced Innate CD8+ T Cells Control Persistent Viral Infection

Ara Lee, Seung Pyo Park, Chan Hee Park, Byung Hyun Kang, Seong Hoe Park, Sang Jun Ha, Kyeong Cheon Jung

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Memory-like CD8+ T cells expressing eomesodermin are a subset of innate T cells initially identified in a number of genetically modified mice, and also exist in wild mice and human. The acquisition of memory phenotype and function by these T cells is dependent on IL–4 produced by PLZF+ innate T cells; however, their physiologic function is still not known. Here we found that these IL-4-induced innate CD8+ T cells are critical for accelerating the control of chronic virus infection. In CIITA-transgenic mice, which have a substantial population of IL-4-induced innate CD8+ T cells, this population facilitated rapid control of viremia and induction of functional anti-viral T-cell responses during infection with chronic form of lymphocytic choriomeningitis virus. Characteristically, anti-viral innate CD8+ T cells accumulated sufficiently during early phase of infection. They produced a robust amount of IFN-γ and TNF-α with enhanced expression of a degranulation marker. Furthermore, this finding was confirmed in wild-type mice. Taken together, the results from our study show that innate CD8+ T cells works as an early defense mechanism against chronic viral infection.

Original languageEnglish
Article numbere1005193
JournalPLoS Pathogens
Volume11
Issue number10
DOIs
Publication statusPublished - 2015 Jan 1

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Virus Diseases
Interleukin-4
T-Lymphocytes
Lymphocytic choriomeningitis virus
Viremia
T-Lymphocyte Subsets
Defense Mechanisms
Infection
Transgenic Mice
Population
Phenotype

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Molecular Biology
  • Genetics
  • Virology

Cite this

Lee, A., Park, S. P., Park, C. H., Kang, B. H., Park, S. H., Ha, S. J., & Jung, K. C. (2015). IL-4 Induced Innate CD8+ T Cells Control Persistent Viral Infection. PLoS Pathogens, 11(10), [e1005193]. https://doi.org/10.1371/journal.ppat.1005193
Lee, Ara ; Park, Seung Pyo ; Park, Chan Hee ; Kang, Byung Hyun ; Park, Seong Hoe ; Ha, Sang Jun ; Jung, Kyeong Cheon. / IL-4 Induced Innate CD8+ T Cells Control Persistent Viral Infection. In: PLoS Pathogens. 2015 ; Vol. 11, No. 10.
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Lee, A, Park, SP, Park, CH, Kang, BH, Park, SH, Ha, SJ & Jung, KC 2015, 'IL-4 Induced Innate CD8+ T Cells Control Persistent Viral Infection', PLoS Pathogens, vol. 11, no. 10, e1005193. https://doi.org/10.1371/journal.ppat.1005193

IL-4 Induced Innate CD8+ T Cells Control Persistent Viral Infection. / Lee, Ara; Park, Seung Pyo; Park, Chan Hee; Kang, Byung Hyun; Park, Seong Hoe; Ha, Sang Jun; Jung, Kyeong Cheon.

In: PLoS Pathogens, Vol. 11, No. 10, e1005193, 01.01.2015.

Research output: Contribution to journalArticle

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