Ile-Lys-Val-ala-Val (IKVAV) peptide for neuronal tissue engineering

Rajkumar Patel, Mallesh Santhosh, Jatis Kumar Dash, Rajshekhar Karpoormath, Amitabh Jha, Jeonghun Kwak, Madhumita Patel, Jong Hak Kim

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Despite the great advances in microsurgery, some neural injuries cannot be treated surgically. Stem cell therapy is a potential approach for treating neuroinjuries and neurodegenerative disease. Researchers have developed various bioactive scaffolds for tissue engineering, exhibiting enhanced cell viability, attachment, migration, neurite elongation, and neuronal differentiation, with the aim of developing functional tissue grafts that can be incorporated in vivo. Facilitating the appropriate interactions between the cells and extracellular matrix is crucial in scaffold design. Modification of scaffolds with biofunctional motifs such as growth factors, drugs, or peptides can improve this interaction. In this review, we focus on the laminin-derived Ile-Lys-Val-Ala-Val peptide as a biofunctional epitope for neuronal tissue engineering. Inclusion of this bioactive peptide within a scaffold is known to enhance cell adhesion as well as neuronal differentiation in both 2-dimensional and 3-dimensional environments. The in vivo application of this peptide is also briefly described.

Original languageEnglish
Pages (from-to)4-12
Number of pages9
JournalPolymers for Advanced Technologies
Volume30
Issue number1
DOIs
Publication statusPublished - 2019 Jan

Fingerprint

isoleucyl-lysyl-valyl-alanyl-valine
Tissue engineering
Peptides
Scaffolds (biology)
Scaffolds
Neurodegenerative diseases
Epitopes
Cell adhesion
Laminin
Stem cells
Grafts
Elongation
Intercellular Signaling Peptides and Proteins
Cells
Tissue
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Polymers and Plastics

Cite this

Patel, Rajkumar ; Santhosh, Mallesh ; Dash, Jatis Kumar ; Karpoormath, Rajshekhar ; Jha, Amitabh ; Kwak, Jeonghun ; Patel, Madhumita ; Kim, Jong Hak. / Ile-Lys-Val-ala-Val (IKVAV) peptide for neuronal tissue engineering. In: Polymers for Advanced Technologies. 2019 ; Vol. 30, No. 1. pp. 4-12.
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Patel, R, Santhosh, M, Dash, JK, Karpoormath, R, Jha, A, Kwak, J, Patel, M & Kim, JH 2019, 'Ile-Lys-Val-ala-Val (IKVAV) peptide for neuronal tissue engineering', Polymers for Advanced Technologies, vol. 30, no. 1, pp. 4-12. https://doi.org/10.1002/pat.4442

Ile-Lys-Val-ala-Val (IKVAV) peptide for neuronal tissue engineering. / Patel, Rajkumar; Santhosh, Mallesh; Dash, Jatis Kumar; Karpoormath, Rajshekhar; Jha, Amitabh; Kwak, Jeonghun; Patel, Madhumita; Kim, Jong Hak.

In: Polymers for Advanced Technologies, Vol. 30, No. 1, 01.2019, p. 4-12.

Research output: Contribution to journalReview article

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AU - Patel, Rajkumar

AU - Santhosh, Mallesh

AU - Dash, Jatis Kumar

AU - Karpoormath, Rajshekhar

AU - Jha, Amitabh

AU - Kwak, Jeonghun

AU - Patel, Madhumita

AU - Kim, Jong Hak

PY - 2019/1

Y1 - 2019/1

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AB - Despite the great advances in microsurgery, some neural injuries cannot be treated surgically. Stem cell therapy is a potential approach for treating neuroinjuries and neurodegenerative disease. Researchers have developed various bioactive scaffolds for tissue engineering, exhibiting enhanced cell viability, attachment, migration, neurite elongation, and neuronal differentiation, with the aim of developing functional tissue grafts that can be incorporated in vivo. Facilitating the appropriate interactions between the cells and extracellular matrix is crucial in scaffold design. Modification of scaffolds with biofunctional motifs such as growth factors, drugs, or peptides can improve this interaction. In this review, we focus on the laminin-derived Ile-Lys-Val-Ala-Val peptide as a biofunctional epitope for neuronal tissue engineering. Inclusion of this bioactive peptide within a scaffold is known to enhance cell adhesion as well as neuronal differentiation in both 2-dimensional and 3-dimensional environments. The in vivo application of this peptide is also briefly described.

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Patel R, Santhosh M, Dash JK, Karpoormath R, Jha A, Kwak J et al. Ile-Lys-Val-ala-Val (IKVAV) peptide for neuronal tissue engineering. Polymers for Advanced Technologies. 2019 Jan;30(1):4-12. https://doi.org/10.1002/pat.4442