Ilex paraguariensis extract ameliorates obesity induced by high-fat diet

Potential role of AMPK in the visceral adipose tissue

Jisook Pang, Youngshim Choi, Taesun Park

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

The aim of present study was to investigate the anti-obesity effect of Ilex paraguariensis extract and its molecular mechanism in rats rendered obese by a high-fat diet (HFD). I. paraguariensis extract supplementation significantly lowered body weight, visceral fat-pad weights, blood and hepatic lipid, glucose, insulin, and leptin levels of rats administered HFD. Feeding I. paraguariensis extract reversed the HFD-induced downregulation of the epididymal adipose tissue genes implicated in adipogenesis or thermogenesis, such as peroxisome proliferators' activated receptor γ2, adipocyte fatty acid binding protein, sterol-regulatory-element-binding protein-1c, fatty acid synthase, HMG-CoA reductase, uncoupling protein 2, and uncoupling protein 3. Dietary supplementation with I. paraguariensis extract protected rats from the HFD-induced decreases in the phospho-AMP-activated protein kinase (AMPK)/AMPK and phospho-acetyl-CoA carboxylase (ACC)/ACC protein ratio related to fatty acid oxidation in the edipidymal adipose tissue. The present study reports that the I. paraguariensis extract can have a protective effect against a HFD-induced obesity in rats through an enhanced expression of uncoupling proteins and elevated AMPK phosphorylation in the visceral adipose tissue.

Original languageEnglish
Pages (from-to)178-185
Number of pages8
JournalArchives of Biochemistry and Biophysics
Volume476
Issue number2
DOIs
Publication statusPublished - 2008 Aug 15

Fingerprint

Ilex paraguariensis
AMP-Activated Protein Kinases
Intra-Abdominal Fat
High Fat Diet
Nutrition
Obesity
Fats
Tissue
Rats
Acetyl-CoA Carboxylase
Adipose Tissue
Sterol Regulatory Element Binding Protein 1
Proteins
Hydroxymethylglutaryl CoA Reductases
Fatty Acid Synthases
Fatty Acid-Binding Proteins
Adipogenesis
Peroxisome Proliferator-Activated Receptors
Thermogenesis
Dietary Supplements

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

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Ilex paraguariensis extract ameliorates obesity induced by high-fat diet : Potential role of AMPK in the visceral adipose tissue. / Pang, Jisook; Choi, Youngshim; Park, Taesun.

In: Archives of Biochemistry and Biophysics, Vol. 476, No. 2, 15.08.2008, p. 178-185.

Research output: Contribution to journalArticle

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