Imaging patterns of sonographic lenticulostriate vasculopathy and correlation with clinical and neurodevelopmental outcome

Hyun Joo Shin, Myung Joon Kim, Hye Sun Lee, Ran Namgung, Kook In Park, Mi Jung Lee

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose: To evaluate the relationship between the imaging patterns of lenticulostriate vasculopathy (LSV) and clinical outcomes. Methods: We performed cranial sonography (US) in 110 neonates and evaluated the patterns of visible lenticulostriate vessels with three grades: 0: no vessel seen; 1 (low grade): one or two thin branches seen; and 2 (high grade): more than three prominent branches seen. Color Doppler US was performed on these vessels to evaluate the presence of flow. Associated underlying diseases and the presence of neurodevelopmental delay on follow-up were reviewed retrospectively. Results: There were 51 neonates with associated underlying diseases, including congenital heart diseases (CHD) (n=34) and neonatal hypoxia (n=13). Sonographic LSV was detected in 29.1% cases (22 low- and 10 high-grade cases). Doppler flow was not detected in three patients with CHD (p=0.028). CHD (odds ratio [OR], 25.73; p<0.001), neonatal hypoxia (OR, 7.00; p=0.020), two underlying diseases (OR, 73.232; p<0.001), high-grade LSV (OR, 16.29; p=0.005), and absent color Doppler flow (OR, 40.80; p=0.046) were significantly associated with neurodevelopmental delay in univariate analysis. In multivariate analysis, underlying diseases and absent color Doppler flow were associated with neurodevelopmental delay. Both high LSV grade (area under the receiver operating characteristic curves of 0.901; 95% confidence interval, 0.823-0.979) and absent color Doppler flow (area under the receiver operating characteristic curves of 0.874; 95% confidence interval, 0.803-0.945) had a high predictive power for neurodevelopmental delay. Conclusions: High-grade sonographic LSV and absent color Doppler flow on lenticulostriate vessels were significantly associated with neurodevelopmental delay.

Original languageEnglish
Pages (from-to)367-374
Number of pages8
JournalJournal of Clinical Ultrasound
Volume43
Issue number6
DOIs
Publication statusPublished - 2015 Jul 1

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Basal Ganglia Cerebrovascular Disease
Color
Odds Ratio
Heart Diseases
ROC Curve
Newborn Infant
Confidence Intervals
Ultrasonography
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Shin, Hyun Joo ; Kim, Myung Joon ; Lee, Hye Sun ; Namgung, Ran ; Park, Kook In ; Lee, Mi Jung. / Imaging patterns of sonographic lenticulostriate vasculopathy and correlation with clinical and neurodevelopmental outcome. In: Journal of Clinical Ultrasound. 2015 ; Vol. 43, No. 6. pp. 367-374.
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abstract = "Purpose: To evaluate the relationship between the imaging patterns of lenticulostriate vasculopathy (LSV) and clinical outcomes. Methods: We performed cranial sonography (US) in 110 neonates and evaluated the patterns of visible lenticulostriate vessels with three grades: 0: no vessel seen; 1 (low grade): one or two thin branches seen; and 2 (high grade): more than three prominent branches seen. Color Doppler US was performed on these vessels to evaluate the presence of flow. Associated underlying diseases and the presence of neurodevelopmental delay on follow-up were reviewed retrospectively. Results: There were 51 neonates with associated underlying diseases, including congenital heart diseases (CHD) (n=34) and neonatal hypoxia (n=13). Sonographic LSV was detected in 29.1{\%} cases (22 low- and 10 high-grade cases). Doppler flow was not detected in three patients with CHD (p=0.028). CHD (odds ratio [OR], 25.73; p<0.001), neonatal hypoxia (OR, 7.00; p=0.020), two underlying diseases (OR, 73.232; p<0.001), high-grade LSV (OR, 16.29; p=0.005), and absent color Doppler flow (OR, 40.80; p=0.046) were significantly associated with neurodevelopmental delay in univariate analysis. In multivariate analysis, underlying diseases and absent color Doppler flow were associated with neurodevelopmental delay. Both high LSV grade (area under the receiver operating characteristic curves of 0.901; 95{\%} confidence interval, 0.823-0.979) and absent color Doppler flow (area under the receiver operating characteristic curves of 0.874; 95{\%} confidence interval, 0.803-0.945) had a high predictive power for neurodevelopmental delay. Conclusions: High-grade sonographic LSV and absent color Doppler flow on lenticulostriate vessels were significantly associated with neurodevelopmental delay.",
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Imaging patterns of sonographic lenticulostriate vasculopathy and correlation with clinical and neurodevelopmental outcome. / Shin, Hyun Joo; Kim, Myung Joon; Lee, Hye Sun; Namgung, Ran; Park, Kook In; Lee, Mi Jung.

In: Journal of Clinical Ultrasound, Vol. 43, No. 6, 01.07.2015, p. 367-374.

Research output: Contribution to journalArticle

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T1 - Imaging patterns of sonographic lenticulostriate vasculopathy and correlation with clinical and neurodevelopmental outcome

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AU - Kim, Myung Joon

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N2 - Purpose: To evaluate the relationship between the imaging patterns of lenticulostriate vasculopathy (LSV) and clinical outcomes. Methods: We performed cranial sonography (US) in 110 neonates and evaluated the patterns of visible lenticulostriate vessels with three grades: 0: no vessel seen; 1 (low grade): one or two thin branches seen; and 2 (high grade): more than three prominent branches seen. Color Doppler US was performed on these vessels to evaluate the presence of flow. Associated underlying diseases and the presence of neurodevelopmental delay on follow-up were reviewed retrospectively. Results: There were 51 neonates with associated underlying diseases, including congenital heart diseases (CHD) (n=34) and neonatal hypoxia (n=13). Sonographic LSV was detected in 29.1% cases (22 low- and 10 high-grade cases). Doppler flow was not detected in three patients with CHD (p=0.028). CHD (odds ratio [OR], 25.73; p<0.001), neonatal hypoxia (OR, 7.00; p=0.020), two underlying diseases (OR, 73.232; p<0.001), high-grade LSV (OR, 16.29; p=0.005), and absent color Doppler flow (OR, 40.80; p=0.046) were significantly associated with neurodevelopmental delay in univariate analysis. In multivariate analysis, underlying diseases and absent color Doppler flow were associated with neurodevelopmental delay. Both high LSV grade (area under the receiver operating characteristic curves of 0.901; 95% confidence interval, 0.823-0.979) and absent color Doppler flow (area under the receiver operating characteristic curves of 0.874; 95% confidence interval, 0.803-0.945) had a high predictive power for neurodevelopmental delay. Conclusions: High-grade sonographic LSV and absent color Doppler flow on lenticulostriate vessels were significantly associated with neurodevelopmental delay.

AB - Purpose: To evaluate the relationship between the imaging patterns of lenticulostriate vasculopathy (LSV) and clinical outcomes. Methods: We performed cranial sonography (US) in 110 neonates and evaluated the patterns of visible lenticulostriate vessels with three grades: 0: no vessel seen; 1 (low grade): one or two thin branches seen; and 2 (high grade): more than three prominent branches seen. Color Doppler US was performed on these vessels to evaluate the presence of flow. Associated underlying diseases and the presence of neurodevelopmental delay on follow-up were reviewed retrospectively. Results: There were 51 neonates with associated underlying diseases, including congenital heart diseases (CHD) (n=34) and neonatal hypoxia (n=13). Sonographic LSV was detected in 29.1% cases (22 low- and 10 high-grade cases). Doppler flow was not detected in three patients with CHD (p=0.028). CHD (odds ratio [OR], 25.73; p<0.001), neonatal hypoxia (OR, 7.00; p=0.020), two underlying diseases (OR, 73.232; p<0.001), high-grade LSV (OR, 16.29; p=0.005), and absent color Doppler flow (OR, 40.80; p=0.046) were significantly associated with neurodevelopmental delay in univariate analysis. In multivariate analysis, underlying diseases and absent color Doppler flow were associated with neurodevelopmental delay. Both high LSV grade (area under the receiver operating characteristic curves of 0.901; 95% confidence interval, 0.823-0.979) and absent color Doppler flow (area under the receiver operating characteristic curves of 0.874; 95% confidence interval, 0.803-0.945) had a high predictive power for neurodevelopmental delay. Conclusions: High-grade sonographic LSV and absent color Doppler flow on lenticulostriate vessels were significantly associated with neurodevelopmental delay.

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