Immunogenetic and nutritional profile in insulin-using youth-onset diabetics in Korea

Kap Bum Huh, Hyun Chul Lee, Hyeon Man Kim, Yong Wook Cho, Yoo Lee Kim, Kwan Woo Lee, Eun Jig Lee, Sung Kil Lim, Duk Hi Kim, Ji Won Yoon

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14 Citations (Scopus)


There are few reports on the genetic, immunological and nutritional characteristics of insulin-using youth-onset diabetes mellitus, insulin-dependent diabetes mellitus (IDDM) and malnutrition-related diabetes mellitus (MRDM) in Korea. Among 1266 hospitalized Korean diabetics, 29 (2.3%) were IDDM and 84 (6.6%) were MRDM. A diabetes history of first-relatives (28.6%) was more frequently found in the MRDM group than in the IDDM (14.8) and non-insulin-dependent diabetes mellitus (NIDDM) (19.0%) groups. HLA-DR4 was more common among IDDM (54.2%) and MRDM (52.4%) patients than controls (26.3%), and HLA-DR3 was more common among only IDDM patients (29.2%) than controls (10.9%). Conventional islet-cell antibodies were detected in 8 of 15 IDDM patients tested (53.3%) and in 11 of 22 MRDM patients (50.0%). MRDM patients had higher serum basal (1.02 ± 0.51 ng/ml) and peak (1.44 ± 0.76 ng/ml) C-peptide concentrations than IDDM patients, but lower concentrations than NIDDM patients. Before the onset of diabetes, the calorie intake of 21 MRDM patients assessed was 63.1% of the daily requirement and the intake of carbohydrate, protein and fat was 71.7%, 55.9% and 39.8%, respectively. In summary, our data suggest that IDDM in Korea is associated with HLA-DR3 or HLA-DR4, indicating a risk for IDDM in Western societies; furthermore, MRDM has a history of undernutrition at the preonset period and is also associated with HLA-DR4. It might be also concluded that MRDM in Korea is another expression of IDDM caused by the shortage of some nutrients for the structural and/or functional maintenance of pancreatic β-cells.

Original languageEnglish
Pages (from-to)63-70
Number of pages8
JournalDiabetes Research and Clinical Practice
Issue number1
Publication statusPublished - 1992 Apr

Bibliographical note

Funding Information:
We would like to expresso ur sincere thanks to Miss Karen Clarke, University of Calgary,f or her helpful review and correction of the use of English. This study was supportedb y China Medical Board (Grant No. 86-6).

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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