Immunogenetic and nutritional profile in insulin-using youth-onset diabetics in Korea

Kap Bum Huh, Hyun Chul Lee, Hyeon Man Kim, Yong Wook Cho, Yoo Lee Kim, Kwan Woo Lee, Eunjig Lee, Sungkil Lim, Duk Hi Kim, Ji Won Yoon

Research output: Contribution to journalArticle

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Abstract

There are few reports on the genetic, immunological and nutritional characteristics of insulin-using youth-onset diabetes mellitus, insulin-dependent diabetes mellitus (IDDM) and malnutrition-related diabetes mellitus (MRDM) in Korea. Among 1266 hospitalized Korean diabetics, 29 (2.3%) were IDDM and 84 (6.6%) were MRDM. A diabetes history of first-relatives (28.6%) was more frequently found in the MRDM group than in the IDDM (14.8) and non-insulin-dependent diabetes mellitus (NIDDM) (19.0%) groups. HLA-DR4 was more common among IDDM (54.2%) and MRDM (52.4%) patients than controls (26.3%), and HLA-DR3 was more common among only IDDM patients (29.2%) than controls (10.9%). Conventional islet-cell antibodies were detected in 8 of 15 IDDM patients tested (53.3%) and in 11 of 22 MRDM patients (50.0%). MRDM patients had higher serum basal (1.02 ± 0.51 ng/ml) and peak (1.44 ± 0.76 ng/ml) C-peptide concentrations than IDDM patients, but lower concentrations than NIDDM patients. Before the onset of diabetes, the calorie intake of 21 MRDM patients assessed was 63.1% of the daily requirement and the intake of carbohydrate, protein and fat was 71.7%, 55.9% and 39.8%, respectively. In summary, our data suggest that IDDM in Korea is associated with HLA-DR3 or HLA-DR4, indicating a risk for IDDM in Western societies; furthermore, MRDM has a history of undernutrition at the preonset period and is also associated with HLA-DR4. It might be also concluded that MRDM in Korea is another expression of IDDM caused by the shortage of some nutrients for the structural and/or functional maintenance of pancreatic β-cells.

Original languageEnglish
Pages (from-to)63-70
Number of pages8
JournalDiabetes Research and Clinical Practice
Volume16
Issue number1
DOIs
Publication statusPublished - 1992 Jan 1

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Immunogenetics
Korea
Malnutrition
Type 1 Diabetes Mellitus
Diabetes Mellitus
Insulin
HLA-DR4 Antigen
HLA-DR3 Antigen
Type 2 Diabetes Mellitus
Nutrigenomics
C-Peptide
Fats
Maintenance
Carbohydrates

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Huh, K. B., Lee, H. C., Kim, H. M., Cho, Y. W., Kim, Y. L., Lee, K. W., ... Yoon, J. W. (1992). Immunogenetic and nutritional profile in insulin-using youth-onset diabetics in Korea. Diabetes Research and Clinical Practice, 16(1), 63-70. https://doi.org/10.1016/0168-8227(92)90136-F
Huh, Kap Bum ; Lee, Hyun Chul ; Kim, Hyeon Man ; Cho, Yong Wook ; Kim, Yoo Lee ; Lee, Kwan Woo ; Lee, Eunjig ; Lim, Sungkil ; Kim, Duk Hi ; Yoon, Ji Won. / Immunogenetic and nutritional profile in insulin-using youth-onset diabetics in Korea. In: Diabetes Research and Clinical Practice. 1992 ; Vol. 16, No. 1. pp. 63-70.
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Immunogenetic and nutritional profile in insulin-using youth-onset diabetics in Korea. / Huh, Kap Bum; Lee, Hyun Chul; Kim, Hyeon Man; Cho, Yong Wook; Kim, Yoo Lee; Lee, Kwan Woo; Lee, Eunjig; Lim, Sungkil; Kim, Duk Hi; Yoon, Ji Won.

In: Diabetes Research and Clinical Practice, Vol. 16, No. 1, 01.01.1992, p. 63-70.

Research output: Contribution to journalArticle

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T1 - Immunogenetic and nutritional profile in insulin-using youth-onset diabetics in Korea

AU - Huh, Kap Bum

AU - Lee, Hyun Chul

AU - Kim, Hyeon Man

AU - Cho, Yong Wook

AU - Kim, Yoo Lee

AU - Lee, Kwan Woo

AU - Lee, Eunjig

AU - Lim, Sungkil

AU - Kim, Duk Hi

AU - Yoon, Ji Won

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Y1 - 1992/1/1

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AB - There are few reports on the genetic, immunological and nutritional characteristics of insulin-using youth-onset diabetes mellitus, insulin-dependent diabetes mellitus (IDDM) and malnutrition-related diabetes mellitus (MRDM) in Korea. Among 1266 hospitalized Korean diabetics, 29 (2.3%) were IDDM and 84 (6.6%) were MRDM. A diabetes history of first-relatives (28.6%) was more frequently found in the MRDM group than in the IDDM (14.8) and non-insulin-dependent diabetes mellitus (NIDDM) (19.0%) groups. HLA-DR4 was more common among IDDM (54.2%) and MRDM (52.4%) patients than controls (26.3%), and HLA-DR3 was more common among only IDDM patients (29.2%) than controls (10.9%). Conventional islet-cell antibodies were detected in 8 of 15 IDDM patients tested (53.3%) and in 11 of 22 MRDM patients (50.0%). MRDM patients had higher serum basal (1.02 ± 0.51 ng/ml) and peak (1.44 ± 0.76 ng/ml) C-peptide concentrations than IDDM patients, but lower concentrations than NIDDM patients. Before the onset of diabetes, the calorie intake of 21 MRDM patients assessed was 63.1% of the daily requirement and the intake of carbohydrate, protein and fat was 71.7%, 55.9% and 39.8%, respectively. In summary, our data suggest that IDDM in Korea is associated with HLA-DR3 or HLA-DR4, indicating a risk for IDDM in Western societies; furthermore, MRDM has a history of undernutrition at the preonset period and is also associated with HLA-DR4. It might be also concluded that MRDM in Korea is another expression of IDDM caused by the shortage of some nutrients for the structural and/or functional maintenance of pancreatic β-cells.

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