Immunoglobulin E binding reactivity of a recombinant allergen homologous to α-tubulin from Tyrophagus putrescentiae

Kyoung Yong Jeong, Haeseok Lee, Jae Sik Lee, Jongweon Lee, In Yong Lee, Han Il Ree, Chein Soo Hong, Jung Won Park, Tai Soon Yong

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Storage mites may cause allergic respiratory diseases in urban areas as well as pose an occupational hazard in rural areas. Characterization of storage mite allergens is important for the development of diagnostic and therapeutic agents against mite-associated allergic disorders. Here we report on the cloning and expression of α-tubulin from the storage mite (Tyrophagus putrescentiae). The deduced amino acid sequence of the α-tubulin from the storage mite showed as much as 97.3% identity to the α-tubulin sequences from other organisms. The highly conserved amino acid sequences of α-tubulins across different species of mites may indicate that cross-reactivity for this potential allergen exists. The frequency of immunoglobulin E reactivity of this recombinant protein is 29.3% in sera from storage mite-allergic subjects.

Original languageEnglish
Pages (from-to)1451-1454
Number of pages4
JournalClinical and Diagnostic Laboratory Immunology
Volume12
Issue number12
DOIs
Publication statusPublished - 2005 Dec 1

Fingerprint

Acaridae
Tubulin
Allergens
Immunoglobulin E
Mites
Amino Acid Sequence
Amino Acids
Pulmonary diseases
Cloning
Recombinant Proteins
Hazards
Organism Cloning
Serum

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)

Cite this

Jeong, Kyoung Yong ; Lee, Haeseok ; Lee, Jae Sik ; Lee, Jongweon ; Lee, In Yong ; Ree, Han Il ; Hong, Chein Soo ; Park, Jung Won ; Yong, Tai Soon. / Immunoglobulin E binding reactivity of a recombinant allergen homologous to α-tubulin from Tyrophagus putrescentiae. In: Clinical and Diagnostic Laboratory Immunology. 2005 ; Vol. 12, No. 12. pp. 1451-1454.
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Immunoglobulin E binding reactivity of a recombinant allergen homologous to α-tubulin from Tyrophagus putrescentiae. / Jeong, Kyoung Yong; Lee, Haeseok; Lee, Jae Sik; Lee, Jongweon; Lee, In Yong; Ree, Han Il; Hong, Chein Soo; Park, Jung Won; Yong, Tai Soon.

In: Clinical and Diagnostic Laboratory Immunology, Vol. 12, No. 12, 01.12.2005, p. 1451-1454.

Research output: Contribution to journalArticle

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AU - Lee, In Yong

AU - Ree, Han Il

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AU - Park, Jung Won

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