Immunoglobulin G4-related hypertrophic pachymeningitis involving cerebral parenchyma: Case report

Eui Hyun Kim, Se Hoon Kim, Jin Mo Cho, Jung Yong Ahn, Jong Hee Chang

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52 Citations (Scopus)


The authors report a case of IgG4-related hypertrophic pachymeningitis that involved cerebral parenchyma. The mass was removed surgically. Histopathological studies showed diffuse infiltration of lymphoplasmacytic cells without evidence of Langerhans histiocytes or meningothelial cells. Immunoglobulin G4 was strongly positive on immunohistochemical staining. The Gd-enhanced lesion deep inside brain parenchyma was completely resolved after 3 months of oral corticosteroid medication. A nodular type of hypertrophic pachymeningitis that mimics a meningioma is rare. Nevertheless, preoperative presumption is very important, and immunohistochemical studies for IgG4 may be helpful in the differential diagnosis.

Original languageEnglish
Pages (from-to)1242-1247
Number of pages6
JournalJournal of neurosurgery
Issue number6
Publication statusPublished - 2011 Dec

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology


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