Abstract
Aim: Toll-like receptor 4 (TLR-4) is the major receptor used for recognition of specific gram negative bacteria by the host immune system. The role of TLR-4 has been revealed in preterm parturition. This study aims to demonstrate the immunohistochemical expression of TLR-4 with regard to histological layers and anatomical regions of the human fetal membranes. Material and Methods: Fetal membranes were obtained from the uterine fundus and low segment. Immunohistochemical staining for TLR-4 and hematoxylin and eosin stain were performed. Results: The chorion expressed significantly higher levels of TLR-4 than the amnion (P = 0.001). There was no difference in the expression of TLR-4 between the uterine fundus and the uterine low segment (P = 0.942). There was no significant difference in TLR-4 expression according to the presence of histological chorioamnionitis (P = 0.444). TLR-4 expression decreased significantly with the progression of gestation (P = 0.002). Conclusions: The level of expression of TLR-4 did not differ according to anatomic location, but did differ according to the histological layer of the human fetal membranes and gestational age. These results suggest that TLR-4 may be involved in preterm parturition.
| Original language | English |
|---|---|
| Pages (from-to) | 108-112 |
| Number of pages | 5 |
| Journal | Journal of Obstetrics and Gynaecology Research |
| Volume | 38 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2012 Jan 1 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Obstetrics and Gynaecology
Cite this
}
Immunohistochemical distribution of toll-like receptor 4 in preterm human fetal membrane. / Choi, Seong Jin; Jung, Soon Hee; Eom, Minseob; Han, Kyoung Hee; Chung, In Bai; Kim, Soo Ki.
In: Journal of Obstetrics and Gynaecology Research, Vol. 38, No. 1, 01.01.2012, p. 108-112.Research output: Contribution to journal › Article
TY - JOUR
T1 - Immunohistochemical distribution of toll-like receptor 4 in preterm human fetal membrane
AU - Choi, Seong Jin
AU - Jung, Soon Hee
AU - Eom, Minseob
AU - Han, Kyoung Hee
AU - Chung, In Bai
AU - Kim, Soo Ki
PY - 2012/1/1
Y1 - 2012/1/1
N2 - Aim: Toll-like receptor 4 (TLR-4) is the major receptor used for recognition of specific gram negative bacteria by the host immune system. The role of TLR-4 has been revealed in preterm parturition. This study aims to demonstrate the immunohistochemical expression of TLR-4 with regard to histological layers and anatomical regions of the human fetal membranes. Material and Methods: Fetal membranes were obtained from the uterine fundus and low segment. Immunohistochemical staining for TLR-4 and hematoxylin and eosin stain were performed. Results: The chorion expressed significantly higher levels of TLR-4 than the amnion (P = 0.001). There was no difference in the expression of TLR-4 between the uterine fundus and the uterine low segment (P = 0.942). There was no significant difference in TLR-4 expression according to the presence of histological chorioamnionitis (P = 0.444). TLR-4 expression decreased significantly with the progression of gestation (P = 0.002). Conclusions: The level of expression of TLR-4 did not differ according to anatomic location, but did differ according to the histological layer of the human fetal membranes and gestational age. These results suggest that TLR-4 may be involved in preterm parturition.
AB - Aim: Toll-like receptor 4 (TLR-4) is the major receptor used for recognition of specific gram negative bacteria by the host immune system. The role of TLR-4 has been revealed in preterm parturition. This study aims to demonstrate the immunohistochemical expression of TLR-4 with regard to histological layers and anatomical regions of the human fetal membranes. Material and Methods: Fetal membranes were obtained from the uterine fundus and low segment. Immunohistochemical staining for TLR-4 and hematoxylin and eosin stain were performed. Results: The chorion expressed significantly higher levels of TLR-4 than the amnion (P = 0.001). There was no difference in the expression of TLR-4 between the uterine fundus and the uterine low segment (P = 0.942). There was no significant difference in TLR-4 expression according to the presence of histological chorioamnionitis (P = 0.444). TLR-4 expression decreased significantly with the progression of gestation (P = 0.002). Conclusions: The level of expression of TLR-4 did not differ according to anatomic location, but did differ according to the histological layer of the human fetal membranes and gestational age. These results suggest that TLR-4 may be involved in preterm parturition.
UR - http://www.scopus.com/inward/record.url?scp=84863020398&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863020398&partnerID=8YFLogxK
U2 - 10.1111/j.1447-0756.2011.01626.x
DO - 10.1111/j.1447-0756.2011.01626.x
M3 - Article
C2 - 21827576
AN - SCOPUS:84863020398
VL - 38
SP - 108
EP - 112
JO - Journal of Obstetrics and Gynaecology Research
JF - Journal of Obstetrics and Gynaecology Research
SN - 1341-8076
IS - 1
ER -