Immunomodulating Activities of Polysaccharides Isolated from Panax ginseng

Tae Soo Lim, Keun Na, Eun Mi Choi, Jae Youn Chung, Jae-Kwan Hwang

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Panax ginseng C.A. Meyer has been traditionally used for the prevention and treatment of various chronic diseases and infections. Ginseng marc is a fibrous and insoluble by-product remaining after the extraction process of ginseng. In this research an extrusion process was employed to disintegrate the insoluble ginseng marc structure, and water-soluble ginseng marc polysaccharide (GMP) was isolated. GMP was examined for immunomodulatory effects in murine peritoneal macrophages. GMP significantly increased the lysosomal phosphatase activity and the phagocytic index of peritoneal macrophages (P < .05). The peritoneal macrophages treated with GMP also produced significantly more H 2O2 and nitrite than the control without GMP treatment (P < .05). In addition, GMP (100 μg/mL) significantly increased the cell viability of peritoneal macrophages (P < .05). These results suggest that GMP is an effective nonspecific immunomodulatory agent, and its immunostimulating effects may be due to its ability to stimulate the production of reactive oxygen intermediates.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalJournal of medicinal food
Volume7
Issue number1
DOIs
Publication statusPublished - 2004 Mar 1

Fingerprint

Panax
Polysaccharides
Peritoneal Macrophages
Nitrites
Phosphoric Monoester Hydrolases
Cell Survival
Chronic Disease
Oxygen

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Lim, Tae Soo ; Na, Keun ; Choi, Eun Mi ; Chung, Jae Youn ; Hwang, Jae-Kwan. / Immunomodulating Activities of Polysaccharides Isolated from Panax ginseng. In: Journal of medicinal food. 2004 ; Vol. 7, No. 1. pp. 1-6.
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Immunomodulating Activities of Polysaccharides Isolated from Panax ginseng. / Lim, Tae Soo; Na, Keun; Choi, Eun Mi; Chung, Jae Youn; Hwang, Jae-Kwan.

In: Journal of medicinal food, Vol. 7, No. 1, 01.03.2004, p. 1-6.

Research output: Contribution to journalArticle

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