Immunomodulatory activity of type-4 resistant starch in the mesenteric lymph nodes of rats

Youngju Song, Chunho Bae, Dongho Woo, Yunjung Kim, Taesun Park

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We evaluated the immunomodulatory activity of type-4 resistant starch (RS) in mesenteric lymph nodes (MLNs) using a rat model. Sixteen male Sprague-Dawley rats were fed either a cellulose diet or an RS diet (RSD) for 4 weeks. Serum immunoglobulin A levels, as well as the CD4 + T cell population and the ratio of CD4 +/CD8 + T cells in the MLNs of rats, were significantly elevated by replacing cellulose with RS in the diet. The survival rate of concanavalin A (Con A)-stimulated MLN lymphocytes and interleukin-4 secretion from the Con A-stimulated MLN lymphocytes were significantly increased in rats fed RSD. These results indicate that type-4 RS might ameliorate allergic inflammation in the MLNs of rats through an increased CD4 + T cell population and enhanced differentiation of MLN lymphocytes into type-2 T cells.

Original languageEnglish
Pages (from-to)205-210
Number of pages6
JournalJournal of medicinal food
Issue number1
Publication statusPublished - 2010 Feb 1


All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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