Immunomodulatory roles of PE/PPE proteins and their implications in genomic features of Mycobacterium tuberculosis

Soo Young Choi, SungJae Shin

Research output: Contribution to journalReview article

Abstract

Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a notorious cause of human death worldwide. A deeper understanding of the proline-glutamate (PE) and proline-proline-glutamate (PPE) families, which compromise 10% of the coding regions in the Mtb genome, has uncovered their unique roles in host-pathogen interactions. Further, comparative genomic analysis of different Mtb strains has proposed that Mtb has acquired diverse gene sets that play immunomodulatory roles in host-pathogen interactions. This review delineates the various immunomodulatory roles of PE/PPE antigens and discusses their implications in the development of the improved diagnostic tools and vaccines.

Original languageEnglish
Pages (from-to)272-281
Number of pages10
JournalJournal of Bacteriology and Virology
Volume45
Issue number3
DOIs
Publication statusPublished - 2015 Jan 1

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Mycobacterium tuberculosis
Proline
Glutamic Acid
Host-Pathogen Interactions
Proteins
Cause of Death
Tuberculosis
Vaccines
Genome
Antigens
Genes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Virology

Cite this

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abstract = "Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a notorious cause of human death worldwide. A deeper understanding of the proline-glutamate (PE) and proline-proline-glutamate (PPE) families, which compromise 10{\%} of the coding regions in the Mtb genome, has uncovered their unique roles in host-pathogen interactions. Further, comparative genomic analysis of different Mtb strains has proposed that Mtb has acquired diverse gene sets that play immunomodulatory roles in host-pathogen interactions. This review delineates the various immunomodulatory roles of PE/PPE antigens and discusses their implications in the development of the improved diagnostic tools and vaccines.",
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Immunomodulatory roles of PE/PPE proteins and their implications in genomic features of Mycobacterium tuberculosis. / Choi, Soo Young; Shin, SungJae.

In: Journal of Bacteriology and Virology, Vol. 45, No. 3, 01.01.2015, p. 272-281.

Research output: Contribution to journalReview article

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