Immunophenotypes of glycogen rich clear cell carcinoma

Sung Eun Kim, Ja Seung Koo, Woo Hee Jung

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: Glycogen rich clear cell carcinoma (GRCC) of the breast is a rare subtype of invasive ductal carcinoma and involves a poor prognosis. In the literature, less than 150 cases have been reported. Many researchers have attempted to characterize GRCC according to electron microscope, flow cytometry, or clinical data. However, an organized study of the immunophenotype of GRCC has yet to be reported. Materials and Methods: Here, we present three cases of GRCC and their immunohistochemical profiles. Results: Histologically, all three cases contained periodic acid stain (PAS) positive and d-PAS labile granules in their clear cytoplasm. Case I showed positivity for only estrogen receptor (ER) and c-erbB2. Case II exhibited positivity for progesterone receptor and negativity for ER and c-erbB2. Case III presented with triple negative invasive carcinoma. The expression pattern of E-cadherin was concordant with epidermal growth factor receptor and c-kit, but discordant with ki-67. Among these three cases, p53-positive cases exhibited a low proliferative index (ki-67: 15%), while p53-negative cases showed a high proliferative index (ki-67: 50-60%). Conclusion: In conclusion, the immunophenotype of GRCC is not uniform, but is similar to that of conventional ductal carcinoma.

Original languageEnglish
Pages (from-to)1142-1146
Number of pages5
JournalYonsei medical journal
Volume53
Issue number6
DOIs
Publication statusPublished - 2012 Nov 1

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Glycogen
Carcinoma
Ductal Carcinoma
Periodic Acid
Estrogen Receptors
Coloring Agents
Progesterone Receptors
Cadherins
Epidermal Growth Factor Receptor
Flow Cytometry
Cytoplasm
Research Personnel
Electrons
Breast Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kim, Sung Eun ; Koo, Ja Seung ; Jung, Woo Hee. / Immunophenotypes of glycogen rich clear cell carcinoma. In: Yonsei medical journal. 2012 ; Vol. 53, No. 6. pp. 1142-1146.
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Immunophenotypes of glycogen rich clear cell carcinoma. / Kim, Sung Eun; Koo, Ja Seung; Jung, Woo Hee.

In: Yonsei medical journal, Vol. 53, No. 6, 01.11.2012, p. 1142-1146.

Research output: Contribution to journalArticle

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