Immunosenescent CD8+ T clls and C-X-C cemokine receptor type 3 chemokines are increased in human hypertension

Jong Chan Youn, Hee Tae Yu, Beom Jin Lim, Myoung Ju Koh, Jino Lee, Dong Yeop Chang, Yoon Seok Choi, Sang Hak Lee, seokmin kang, Yangsoo Jang, Ook Joon Yoo, Eui Cheol Shin, Sungha Park

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Abstract

The pathogenic role of T cells in hypertension has been documented well in recent animal studies. However, the existence of T-cell-driven inflammation in human hypertension has not been confirmed. Therefore, we undertook immunologic characterization of T cells from patients with hypertension and measured circulating levels of C-X-C chemokine receptor type 3 chemokines, which are well-known tissue-homing chemokines for T cells. We analyzed immunologic markers on T cells from patients with hypertension by multicolor flow cytometry. We then measured circulating levels of the C-X-C chemokine receptor type 3 chemokines, monokine induced by γ interferon (IFN), IFN γ-induced protein 10, and IFN-inducible T-cell α chemoattractant, in patients with hypertension and in age- and sex-matched control subjects by the cytometric bead array method. In addition, we examined histological features of IFN-inducible T-cell α chemoattractant expression from renal biopsy specimens of patients with hypertensive nephrosclerosis and control subjects. The total T-cell population from patients with hypertension showed an increased fraction of immunosenescent, proinflammatory, cytotoxic CD8+ T cells. Circulating levels of C-X-C chemokine receptor type 3 chemokines were significantly higher in patients with hypertension than in control subjects. Furthermore, immunohistochemical staining revealed increased expression of the T-cell chemokine, IFN-inducible T-cell α chemoattractant, in the proximal and distal tubules of patients with hypertensive nephrosclerosis. Immunosenescent CD8+ T cells and C-X-C chemokine receptor type 3 chemokines are increased in human hypertension, suggesting a role for T-cell-driven inflammation in hypertension. A more detailed characterization of CD8+ T cells may offer new opportunities for the prevention and treatment of human hypertension.

Original languageEnglish
Pages (from-to)126-133
Number of pages8
JournalHypertension
Volume62
Issue number1
DOIs
Publication statusPublished - 2013 Jul 1

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Chemokine Receptors
Hypertension
T-Lymphocytes
Chemokines
CXC Chemokines
Interferons
Chemotactic Factors
Nephrosclerosis
Chemokine CXCL10
Monokines
Inflammation
Flow Cytometry

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Youn, Jong Chan ; Yu, Hee Tae ; Lim, Beom Jin ; Koh, Myoung Ju ; Lee, Jino ; Chang, Dong Yeop ; Choi, Yoon Seok ; Lee, Sang Hak ; kang, seokmin ; Jang, Yangsoo ; Yoo, Ook Joon ; Shin, Eui Cheol ; Park, Sungha. / Immunosenescent CD8+ T clls and C-X-C cemokine receptor type 3 chemokines are increased in human hypertension. In: Hypertension. 2013 ; Vol. 62, No. 1. pp. 126-133.
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abstract = "The pathogenic role of T cells in hypertension has been documented well in recent animal studies. However, the existence of T-cell-driven inflammation in human hypertension has not been confirmed. Therefore, we undertook immunologic characterization of T cells from patients with hypertension and measured circulating levels of C-X-C chemokine receptor type 3 chemokines, which are well-known tissue-homing chemokines for T cells. We analyzed immunologic markers on T cells from patients with hypertension by multicolor flow cytometry. We then measured circulating levels of the C-X-C chemokine receptor type 3 chemokines, monokine induced by γ interferon (IFN), IFN γ-induced protein 10, and IFN-inducible T-cell α chemoattractant, in patients with hypertension and in age- and sex-matched control subjects by the cytometric bead array method. In addition, we examined histological features of IFN-inducible T-cell α chemoattractant expression from renal biopsy specimens of patients with hypertensive nephrosclerosis and control subjects. The total T-cell population from patients with hypertension showed an increased fraction of immunosenescent, proinflammatory, cytotoxic CD8+ T cells. Circulating levels of C-X-C chemokine receptor type 3 chemokines were significantly higher in patients with hypertension than in control subjects. Furthermore, immunohistochemical staining revealed increased expression of the T-cell chemokine, IFN-inducible T-cell α chemoattractant, in the proximal and distal tubules of patients with hypertensive nephrosclerosis. Immunosenescent CD8+ T cells and C-X-C chemokine receptor type 3 chemokines are increased in human hypertension, suggesting a role for T-cell-driven inflammation in hypertension. A more detailed characterization of CD8+ T cells may offer new opportunities for the prevention and treatment of human hypertension.",
author = "Youn, {Jong Chan} and Yu, {Hee Tae} and Lim, {Beom Jin} and Koh, {Myoung Ju} and Jino Lee and Chang, {Dong Yeop} and Choi, {Yoon Seok} and Lee, {Sang Hak} and seokmin kang and Yangsoo Jang and Yoo, {Ook Joon} and Shin, {Eui Cheol} and Sungha Park",
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Youn, JC, Yu, HT, Lim, BJ, Koh, MJ, Lee, J, Chang, DY, Choi, YS, Lee, SH, kang, S, Jang, Y, Yoo, OJ, Shin, EC & Park, S 2013, 'Immunosenescent CD8+ T clls and C-X-C cemokine receptor type 3 chemokines are increased in human hypertension', Hypertension, vol. 62, no. 1, pp. 126-133. https://doi.org/10.1161/HYPERTENSIONAHA.113.00689

Immunosenescent CD8+ T clls and C-X-C cemokine receptor type 3 chemokines are increased in human hypertension. / Youn, Jong Chan; Yu, Hee Tae; Lim, Beom Jin; Koh, Myoung Ju; Lee, Jino; Chang, Dong Yeop; Choi, Yoon Seok; Lee, Sang Hak; kang, seokmin; Jang, Yangsoo; Yoo, Ook Joon; Shin, Eui Cheol; Park, Sungha.

In: Hypertension, Vol. 62, No. 1, 01.07.2013, p. 126-133.

Research output: Contribution to journalArticle

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T1 - Immunosenescent CD8+ T clls and C-X-C cemokine receptor type 3 chemokines are increased in human hypertension

AU - Youn, Jong Chan

AU - Yu, Hee Tae

AU - Lim, Beom Jin

AU - Koh, Myoung Ju

AU - Lee, Jino

AU - Chang, Dong Yeop

AU - Choi, Yoon Seok

AU - Lee, Sang Hak

AU - kang, seokmin

AU - Jang, Yangsoo

AU - Yoo, Ook Joon

AU - Shin, Eui Cheol

AU - Park, Sungha

PY - 2013/7/1

Y1 - 2013/7/1

N2 - The pathogenic role of T cells in hypertension has been documented well in recent animal studies. However, the existence of T-cell-driven inflammation in human hypertension has not been confirmed. Therefore, we undertook immunologic characterization of T cells from patients with hypertension and measured circulating levels of C-X-C chemokine receptor type 3 chemokines, which are well-known tissue-homing chemokines for T cells. We analyzed immunologic markers on T cells from patients with hypertension by multicolor flow cytometry. We then measured circulating levels of the C-X-C chemokine receptor type 3 chemokines, monokine induced by γ interferon (IFN), IFN γ-induced protein 10, and IFN-inducible T-cell α chemoattractant, in patients with hypertension and in age- and sex-matched control subjects by the cytometric bead array method. In addition, we examined histological features of IFN-inducible T-cell α chemoattractant expression from renal biopsy specimens of patients with hypertensive nephrosclerosis and control subjects. The total T-cell population from patients with hypertension showed an increased fraction of immunosenescent, proinflammatory, cytotoxic CD8+ T cells. Circulating levels of C-X-C chemokine receptor type 3 chemokines were significantly higher in patients with hypertension than in control subjects. Furthermore, immunohistochemical staining revealed increased expression of the T-cell chemokine, IFN-inducible T-cell α chemoattractant, in the proximal and distal tubules of patients with hypertensive nephrosclerosis. Immunosenescent CD8+ T cells and C-X-C chemokine receptor type 3 chemokines are increased in human hypertension, suggesting a role for T-cell-driven inflammation in hypertension. A more detailed characterization of CD8+ T cells may offer new opportunities for the prevention and treatment of human hypertension.

AB - The pathogenic role of T cells in hypertension has been documented well in recent animal studies. However, the existence of T-cell-driven inflammation in human hypertension has not been confirmed. Therefore, we undertook immunologic characterization of T cells from patients with hypertension and measured circulating levels of C-X-C chemokine receptor type 3 chemokines, which are well-known tissue-homing chemokines for T cells. We analyzed immunologic markers on T cells from patients with hypertension by multicolor flow cytometry. We then measured circulating levels of the C-X-C chemokine receptor type 3 chemokines, monokine induced by γ interferon (IFN), IFN γ-induced protein 10, and IFN-inducible T-cell α chemoattractant, in patients with hypertension and in age- and sex-matched control subjects by the cytometric bead array method. In addition, we examined histological features of IFN-inducible T-cell α chemoattractant expression from renal biopsy specimens of patients with hypertensive nephrosclerosis and control subjects. The total T-cell population from patients with hypertension showed an increased fraction of immunosenescent, proinflammatory, cytotoxic CD8+ T cells. Circulating levels of C-X-C chemokine receptor type 3 chemokines were significantly higher in patients with hypertension than in control subjects. Furthermore, immunohistochemical staining revealed increased expression of the T-cell chemokine, IFN-inducible T-cell α chemoattractant, in the proximal and distal tubules of patients with hypertensive nephrosclerosis. Immunosenescent CD8+ T cells and C-X-C chemokine receptor type 3 chemokines are increased in human hypertension, suggesting a role for T-cell-driven inflammation in hypertension. A more detailed characterization of CD8+ T cells may offer new opportunities for the prevention and treatment of human hypertension.

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