Impact of 8-week linoleic acid intake in soy oil on Lp-PLA2 activity in healthy adults

Minkyung Kim, Minjoo Kim, Ayoung Lee, Hye Jin Yoo, Jung Soo Her, Sun Ha Jee, Jong Ho Lee

Research output: Contribution to journalArticle

Abstract

Background: No intervention follow-up study has examined the association between plasma n-6 polyunsaturated fatty acids (PUFAs) and lipoprotein-associated phospholipase A2 (Lp-PLA2), which is a risk factor for cardiovascular disease (CVD). We aimed to determine whether the administration of linoleic acid (LA, 18:2n-6) in soy oil affected Lp-PLA2 activity in healthy adults. Methods: Self-reported healthy participants (n = 150) were randomly assigned to three groups: a low LA group, in which 10 mL soy oil was replaced with one apple; a medium LA group, in which the typical food intake was maintained; and a high LA group, in which 1/3 cup of cooked refined rice was replaced with 9.9 g of soy oil capsules daily. Plasma fatty acids and Lp-PLA2 activity were measured along with other CVD risk factors. Results: After 8 weeks of treatment, plasma LA levels decreased in the low LA group and increased in the high LA group. The high LA group showed greater increases in apolipoprotein B (apoB) and oxidized low-density lipoprotein (ox-LDL) than those in the low LA group. Plasma LA levels and Lp-PLA2 activities demonstrated greater increases in the high LA group than those in the medium and low LA groups. Changes in plasma LA positively and independently correlated with changes in Lp-PLA2 activity, which was negatively correlated with changes in collagen-epinephrine closure time (CEPI-CT). Conclusions: An increase in plasma LA following intake of soy oil was independently associated with Lp-PLA2 activity, which was also related to apoB, ox-LDL and CEPI-CT. Trial registration: ClinicalTrail.gov Identifier: NCT02753907 , registered 25 April 2016 (retrospectively registered).

Original languageEnglish
Article number32
JournalNutrition and Metabolism
Volume14
Issue number1
DOIs
Publication statusPublished - 2017 May 8

Fingerprint

1-Alkyl-2-acetylglycerophosphocholine Esterase
Linoleic Acid
Oils
Apolipoproteins B
Epinephrine
Cardiovascular Diseases
Collagen
Malus
Unsaturated Fatty Acids
Capsules
Healthy Volunteers
Fatty Acids
Eating

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Kim, Minkyung ; Kim, Minjoo ; Lee, Ayoung ; Yoo, Hye Jin ; Her, Jung Soo ; Jee, Sun Ha ; Lee, Jong Ho. / Impact of 8-week linoleic acid intake in soy oil on Lp-PLA2 activity in healthy adults. In: Nutrition and Metabolism. 2017 ; Vol. 14, No. 1.
@article{8b36139b38694e70af0dc56ed3086206,
title = "Impact of 8-week linoleic acid intake in soy oil on Lp-PLA2 activity in healthy adults",
abstract = "Background: No intervention follow-up study has examined the association between plasma n-6 polyunsaturated fatty acids (PUFAs) and lipoprotein-associated phospholipase A2 (Lp-PLA2), which is a risk factor for cardiovascular disease (CVD). We aimed to determine whether the administration of linoleic acid (LA, 18:2n-6) in soy oil affected Lp-PLA2 activity in healthy adults. Methods: Self-reported healthy participants (n = 150) were randomly assigned to three groups: a low LA group, in which 10 mL soy oil was replaced with one apple; a medium LA group, in which the typical food intake was maintained; and a high LA group, in which 1/3 cup of cooked refined rice was replaced with 9.9 g of soy oil capsules daily. Plasma fatty acids and Lp-PLA2 activity were measured along with other CVD risk factors. Results: After 8 weeks of treatment, plasma LA levels decreased in the low LA group and increased in the high LA group. The high LA group showed greater increases in apolipoprotein B (apoB) and oxidized low-density lipoprotein (ox-LDL) than those in the low LA group. Plasma LA levels and Lp-PLA2 activities demonstrated greater increases in the high LA group than those in the medium and low LA groups. Changes in plasma LA positively and independently correlated with changes in Lp-PLA2 activity, which was negatively correlated with changes in collagen-epinephrine closure time (CEPI-CT). Conclusions: An increase in plasma LA following intake of soy oil was independently associated with Lp-PLA2 activity, which was also related to apoB, ox-LDL and CEPI-CT. Trial registration: ClinicalTrail.gov Identifier: NCT02753907 , registered 25 April 2016 (retrospectively registered).",
author = "Minkyung Kim and Minjoo Kim and Ayoung Lee and Yoo, {Hye Jin} and Her, {Jung Soo} and Jee, {Sun Ha} and Lee, {Jong Ho}",
year = "2017",
month = "5",
day = "8",
doi = "10.1186/s12986-017-0186-2",
language = "English",
volume = "14",
journal = "Nutrition and Metabolism",
issn = "1743-7075",
publisher = "BioMed Central",
number = "1",

}

Impact of 8-week linoleic acid intake in soy oil on Lp-PLA2 activity in healthy adults. / Kim, Minkyung; Kim, Minjoo; Lee, Ayoung; Yoo, Hye Jin; Her, Jung Soo; Jee, Sun Ha; Lee, Jong Ho.

In: Nutrition and Metabolism, Vol. 14, No. 1, 32, 08.05.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of 8-week linoleic acid intake in soy oil on Lp-PLA2 activity in healthy adults

AU - Kim, Minkyung

AU - Kim, Minjoo

AU - Lee, Ayoung

AU - Yoo, Hye Jin

AU - Her, Jung Soo

AU - Jee, Sun Ha

AU - Lee, Jong Ho

PY - 2017/5/8

Y1 - 2017/5/8

N2 - Background: No intervention follow-up study has examined the association between plasma n-6 polyunsaturated fatty acids (PUFAs) and lipoprotein-associated phospholipase A2 (Lp-PLA2), which is a risk factor for cardiovascular disease (CVD). We aimed to determine whether the administration of linoleic acid (LA, 18:2n-6) in soy oil affected Lp-PLA2 activity in healthy adults. Methods: Self-reported healthy participants (n = 150) were randomly assigned to three groups: a low LA group, in which 10 mL soy oil was replaced with one apple; a medium LA group, in which the typical food intake was maintained; and a high LA group, in which 1/3 cup of cooked refined rice was replaced with 9.9 g of soy oil capsules daily. Plasma fatty acids and Lp-PLA2 activity were measured along with other CVD risk factors. Results: After 8 weeks of treatment, plasma LA levels decreased in the low LA group and increased in the high LA group. The high LA group showed greater increases in apolipoprotein B (apoB) and oxidized low-density lipoprotein (ox-LDL) than those in the low LA group. Plasma LA levels and Lp-PLA2 activities demonstrated greater increases in the high LA group than those in the medium and low LA groups. Changes in plasma LA positively and independently correlated with changes in Lp-PLA2 activity, which was negatively correlated with changes in collagen-epinephrine closure time (CEPI-CT). Conclusions: An increase in plasma LA following intake of soy oil was independently associated with Lp-PLA2 activity, which was also related to apoB, ox-LDL and CEPI-CT. Trial registration: ClinicalTrail.gov Identifier: NCT02753907 , registered 25 April 2016 (retrospectively registered).

AB - Background: No intervention follow-up study has examined the association between plasma n-6 polyunsaturated fatty acids (PUFAs) and lipoprotein-associated phospholipase A2 (Lp-PLA2), which is a risk factor for cardiovascular disease (CVD). We aimed to determine whether the administration of linoleic acid (LA, 18:2n-6) in soy oil affected Lp-PLA2 activity in healthy adults. Methods: Self-reported healthy participants (n = 150) were randomly assigned to three groups: a low LA group, in which 10 mL soy oil was replaced with one apple; a medium LA group, in which the typical food intake was maintained; and a high LA group, in which 1/3 cup of cooked refined rice was replaced with 9.9 g of soy oil capsules daily. Plasma fatty acids and Lp-PLA2 activity were measured along with other CVD risk factors. Results: After 8 weeks of treatment, plasma LA levels decreased in the low LA group and increased in the high LA group. The high LA group showed greater increases in apolipoprotein B (apoB) and oxidized low-density lipoprotein (ox-LDL) than those in the low LA group. Plasma LA levels and Lp-PLA2 activities demonstrated greater increases in the high LA group than those in the medium and low LA groups. Changes in plasma LA positively and independently correlated with changes in Lp-PLA2 activity, which was negatively correlated with changes in collagen-epinephrine closure time (CEPI-CT). Conclusions: An increase in plasma LA following intake of soy oil was independently associated with Lp-PLA2 activity, which was also related to apoB, ox-LDL and CEPI-CT. Trial registration: ClinicalTrail.gov Identifier: NCT02753907 , registered 25 April 2016 (retrospectively registered).

UR - http://www.scopus.com/inward/record.url?scp=85018402216&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018402216&partnerID=8YFLogxK

U2 - 10.1186/s12986-017-0186-2

DO - 10.1186/s12986-017-0186-2

M3 - Article

VL - 14

JO - Nutrition and Metabolism

JF - Nutrition and Metabolism

SN - 1743-7075

IS - 1

M1 - 32

ER -