Impact of age and sex on left ventricular function determined by coronary computed tomographic angiography: Results from the prospective multicentre CONFIRM study

Catherine Gebhard, Ronny R. Buechel, Barbara E. Stähli, Heidi Gransar, Stephan Achenbach, Daniel S. Berman, Matthew J. Budoff, Tracy Q. Callister, Benjamin Chow, Allison Dunning, Mouaz H. Al-Mallah, Filippo Cademartiri, Kavitha Chinnaiyan, Ronen Rubinshtein, Hugo Marques, Augustin DeLago, Todd C. Villines, Martin Hadamitzky, Joerg Hausleiter, Leslee J. ShawRicardo C. Cury, Gudrun Feuchtner, Yong Jin Kim, Erica Maffei, Gilbert Raff, Gianluca Pontone, Daniele Andreini, Hyuk Jae Chang, Jonathon Leipsic, James K. Min, Philipp A. Kaufmann

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Background Left ventricular (LV) volumetric and functional parameters measured with cardiac computed tomography (cardiac CT) augment risk prediction and discrimination for future mortality. Gender- and age-specific standard values for LV dimensions and systolic function obtained by 64-slice cardiac CT are lacking Methods 1155 patients from the Coronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter and results registry (54.5% males, mean age 53.1 + 12.4 years, range: 18 – 92 years) without known coronary artery disease (CAD), structural heart disease, diabetes, or hypertension who underwent cardiac CT for various indications were categorized according to age and sex. A cardiac CT data acquisition protocol was used that allowed volumetric measuring of LV function. Image interpretation was performed at each site. Patients with significant CAD (.50% stenosis) on cardiac CT were excluded from the analysis. Overall, mean left ventricular ejection fraction (LVEF) was higher in women when compared with men (66.6 + 7.7% vs. 64.6 + 8.1%, P, 0.001). This gender-difference in overall LVEF was caused by a significantly higher LVEF in women ≥70 years when compared with men ≥70 years (69.95 + 8.89% vs. 65.50 + 9.42%, P ¼ 0.004). Accordingly, a significant increase in LVEF was observed with age (P ¼ 0.005 for males and P, 0.001 for females), which was more pronounced in females (5.21%) than in males (2.6%). LV end-diastolic volume decreased in females from 122.48+27.87 (,40 years) to 95.56+23.17 (.70 years; P, 0.001) and in males from 155.22+35.07 (,40 years) to 130.26+27.18 (.70 years; P, 0.001). Conclusion Our findings indicate that the LV undergoes a lifelong remodelling and highlight the need for age and gender adjusted reference values.

Original languageEnglish
Pages (from-to)990-1000
Number of pages11
JournalEuropean heart journal cardiovascular Imaging
Volume18
Issue number9
DOIs
Publication statusPublished - 2017 Sep 1

Bibliographical note

Funding Information:
Novartis, Switzerland, the Olten Heart Foundation, Switzerland, and the Swiss National Science Foundation. J.K.M. received modest speakers’ bureau and medical advisory board compensation and significant research support from GE Healthcare. S.A. received grant support from Siemens and Bayer Schering Pharma and has served as a consultant for Servier. M.H.A.-M. received support from the American Heart Association, BCBS Foundation of Michigan, and As-tellas. F.C. received grant support from GE Healthcare and has served on the Speakers’ Bureau of Bracco and as a consultant for Servier; E.M. received grant support from GE Healthcare. K.C. received grant support from Bayer Pharma and Blue Cross Blue Shield Blue Care MI. B.C. received research and fellowship support from GE Healthcare, research support from Pfizer and AstraZeneca, and educational support from TeraRecon. J.H. received a research grant from Siemens Medical Systems. P.A.K. received institutional research support from GE Healthcare and grant support from Swiss National Science Foundation. E.M. received grant support from GE Healthcare. G.R. received grant support from Siemens, Blue Cross Blue Shield Blue Care MI, and Bayer Pharma. J.L. has received research support and serves on the speakers bureau for GE Healthcare.

Funding Information:
Conflicts of interest: T.C.V. has received speaker’s honoraria from Boehringer-Ingelheim, Ingelheim, Germany. S.A. has received grant support from Siemens Healthcare, Erlangen, Germany, and Bayer Schering Pharma AG, Berlin, Germany. M.J.B. has received speaker’s honoraria from GE Healthcare, Milwaukee, Wisconsin.. F.C. has received grant support from GE Healthcare and speaker’s honoraria from Bracco Diagnostics, Milan, Italy. T.Q.C. is on the speaker’s bureau of GE Healthcare. K.C. has received grant support from Bayer Pharma AG, Berlin, Germany, and Blue Cross Blue Shield Blue Care Michigan. B.C. has received research support from GE Healthcare; Pfizer, Inc., New York; and AstraZeneca, Wilmington, Delaware. B.C. has received educational support from TeraRecon, Foster City, California. J.H. has received research grant support from Siemens Healthcare. P.A.K. has received research support from GE Healthcare and grant support from the Swiss National Science Foundation, Bern, Switzerland. E.M. has received grant support from GE Healthcare and is a consultant for Servier, Neuilly-sur-Seine, France. G.R. has received grant support from Siemens Healthcare, Blue Cross Blue Shield Blue Care Michigan, and Bayer Pharma AG. J.L. is a consultant for GE Healthcare, Philips Healthcare, and Samsung. J.K.M. has received speaker’s honoraria and research support from and serves on the medical advisory board of GE Healthcare. C.G. and B.E.S. have received grant support from

Publisher Copyright:
© The Author 2016.

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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