Impact of atopy on asthma and allergic rhinitis in the cohort for reality and evolution of adult asthma in korea

An Soo Jang, Sang Heon Kim, Tae Bum Kim, Heung Woo Park, Sae Hoon Kim, Yoon Seok Chang, Jae Hyun Lee, You Sook Cho, Jungwon Park, Dong Ho Nahm, Young Joo Cho, Sang Heon Cho, Ho Joo Yoon, Byoung Whui Choi, Hee Bom Moon, Choon Sik Park

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Purpose: Atopy is an important cause of asthma. Few data on the prevalence of atopy or comparisons with clinical characteristics of asthma in Korean patients have been published. We evaluated the effects of atopy on clinical profiles and airway inflammation in Korean asthmatics. Methods: We retrospectively enrolled 1,492 asthmatics from the Cohort for Reality and Evolution of Adult Asthma in Korea (COREA) cohort who had undergone skin prick tests for aeroallergens. The patients' clinical characteristics, lung function, PC20, and sputum and blood inflammatory cell counts were compared based on the presence or absence of atopy. Atopy was defined as one or more positive reactions (A/H ratio >1) on a skin prick test. Results: Among 11 aeroallergens, house dust mites (Dermatophagoides farinae and Dermatophagoides pteronyssinus) were the most prevalent cause of a positive skin prick test. As compared with non-atopic asthmatics, atopic asthmatics showed early onset of the disease. Atopic patients with asthma had a higher FEV1, FVC, and FEV1/FVC as compared with non-atopic patients with asthma. In addition, asthmatics without atopy had more uncontrolled asthma (P=0.001) and severe rhinitis (P<0.05) as compared with atopic asthmatics. Smoking, as measured in pack years, was higher in the non-atopic asthmatics than in the atopic asthmatics. The erythrocyte sedimentation rate was higher in non-atopic asthmatics than in the atopic asthmatics and patients with non-atopic asthma had a higher sputum neutrophil count than did those with atopic asthma. Conclusions: Our data indicate that atopic asthmatics had an early onset of disease and high IgE levels, while the non-atopic asthmatics had decreased lung function and a high sputum neutrophil count, suggesting that a different approach is needed to treat atopic asthma.

Original languageEnglish
Pages (from-to)143-149
Number of pages7
JournalAllergy, Asthma and Immunology Research
Volume5
Issue number3
DOIs
Publication statusPublished - 2013 May 1

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Korea
Asthma
Skin Tests
Sputum
Neutrophils
Dermatophagoides farinae
Dermatophagoides pteronyssinus
Allergic Rhinitis
Pyroglyphidae
Lung
Blood Cell Count
Blood Sedimentation
Rhinitis
Immunoglobulin E
Smoking
Inflammation

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

Cite this

Jang, An Soo ; Kim, Sang Heon ; Kim, Tae Bum ; Park, Heung Woo ; Kim, Sae Hoon ; Chang, Yoon Seok ; Lee, Jae Hyun ; Cho, You Sook ; Park, Jungwon ; Nahm, Dong Ho ; Cho, Young Joo ; Cho, Sang Heon ; Yoon, Ho Joo ; Choi, Byoung Whui ; Moon, Hee Bom ; Park, Choon Sik. / Impact of atopy on asthma and allergic rhinitis in the cohort for reality and evolution of adult asthma in korea. In: Allergy, Asthma and Immunology Research. 2013 ; Vol. 5, No. 3. pp. 143-149.
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abstract = "Purpose: Atopy is an important cause of asthma. Few data on the prevalence of atopy or comparisons with clinical characteristics of asthma in Korean patients have been published. We evaluated the effects of atopy on clinical profiles and airway inflammation in Korean asthmatics. Methods: We retrospectively enrolled 1,492 asthmatics from the Cohort for Reality and Evolution of Adult Asthma in Korea (COREA) cohort who had undergone skin prick tests for aeroallergens. The patients' clinical characteristics, lung function, PC20, and sputum and blood inflammatory cell counts were compared based on the presence or absence of atopy. Atopy was defined as one or more positive reactions (A/H ratio >1) on a skin prick test. Results: Among 11 aeroallergens, house dust mites (Dermatophagoides farinae and Dermatophagoides pteronyssinus) were the most prevalent cause of a positive skin prick test. As compared with non-atopic asthmatics, atopic asthmatics showed early onset of the disease. Atopic patients with asthma had a higher FEV1, FVC, and FEV1/FVC as compared with non-atopic patients with asthma. In addition, asthmatics without atopy had more uncontrolled asthma (P=0.001) and severe rhinitis (P<0.05) as compared with atopic asthmatics. Smoking, as measured in pack years, was higher in the non-atopic asthmatics than in the atopic asthmatics. The erythrocyte sedimentation rate was higher in non-atopic asthmatics than in the atopic asthmatics and patients with non-atopic asthma had a higher sputum neutrophil count than did those with atopic asthma. Conclusions: Our data indicate that atopic asthmatics had an early onset of disease and high IgE levels, while the non-atopic asthmatics had decreased lung function and a high sputum neutrophil count, suggesting that a different approach is needed to treat atopic asthma.",
author = "Jang, {An Soo} and Kim, {Sang Heon} and Kim, {Tae Bum} and Park, {Heung Woo} and Kim, {Sae Hoon} and Chang, {Yoon Seok} and Lee, {Jae Hyun} and Cho, {You Sook} and Jungwon Park and Nahm, {Dong Ho} and Cho, {Young Joo} and Cho, {Sang Heon} and Yoon, {Ho Joo} and Choi, {Byoung Whui} and Moon, {Hee Bom} and Park, {Choon Sik}",
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Jang, AS, Kim, SH, Kim, TB, Park, HW, Kim, SH, Chang, YS, Lee, JH, Cho, YS, Park, J, Nahm, DH, Cho, YJ, Cho, SH, Yoon, HJ, Choi, BW, Moon, HB & Park, CS 2013, 'Impact of atopy on asthma and allergic rhinitis in the cohort for reality and evolution of adult asthma in korea', Allergy, Asthma and Immunology Research, vol. 5, no. 3, pp. 143-149. https://doi.org/10.4168/aair.2013.5.3.143

Impact of atopy on asthma and allergic rhinitis in the cohort for reality and evolution of adult asthma in korea. / Jang, An Soo; Kim, Sang Heon; Kim, Tae Bum; Park, Heung Woo; Kim, Sae Hoon; Chang, Yoon Seok; Lee, Jae Hyun; Cho, You Sook; Park, Jungwon; Nahm, Dong Ho; Cho, Young Joo; Cho, Sang Heon; Yoon, Ho Joo; Choi, Byoung Whui; Moon, Hee Bom; Park, Choon Sik.

In: Allergy, Asthma and Immunology Research, Vol. 5, No. 3, 01.05.2013, p. 143-149.

Research output: Contribution to journalArticle

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T1 - Impact of atopy on asthma and allergic rhinitis in the cohort for reality and evolution of adult asthma in korea

AU - Jang, An Soo

AU - Kim, Sang Heon

AU - Kim, Tae Bum

AU - Park, Heung Woo

AU - Kim, Sae Hoon

AU - Chang, Yoon Seok

AU - Lee, Jae Hyun

AU - Cho, You Sook

AU - Park, Jungwon

AU - Nahm, Dong Ho

AU - Cho, Young Joo

AU - Cho, Sang Heon

AU - Yoon, Ho Joo

AU - Choi, Byoung Whui

AU - Moon, Hee Bom

AU - Park, Choon Sik

PY - 2013/5/1

Y1 - 2013/5/1

N2 - Purpose: Atopy is an important cause of asthma. Few data on the prevalence of atopy or comparisons with clinical characteristics of asthma in Korean patients have been published. We evaluated the effects of atopy on clinical profiles and airway inflammation in Korean asthmatics. Methods: We retrospectively enrolled 1,492 asthmatics from the Cohort for Reality and Evolution of Adult Asthma in Korea (COREA) cohort who had undergone skin prick tests for aeroallergens. The patients' clinical characteristics, lung function, PC20, and sputum and blood inflammatory cell counts were compared based on the presence or absence of atopy. Atopy was defined as one or more positive reactions (A/H ratio >1) on a skin prick test. Results: Among 11 aeroallergens, house dust mites (Dermatophagoides farinae and Dermatophagoides pteronyssinus) were the most prevalent cause of a positive skin prick test. As compared with non-atopic asthmatics, atopic asthmatics showed early onset of the disease. Atopic patients with asthma had a higher FEV1, FVC, and FEV1/FVC as compared with non-atopic patients with asthma. In addition, asthmatics without atopy had more uncontrolled asthma (P=0.001) and severe rhinitis (P<0.05) as compared with atopic asthmatics. Smoking, as measured in pack years, was higher in the non-atopic asthmatics than in the atopic asthmatics. The erythrocyte sedimentation rate was higher in non-atopic asthmatics than in the atopic asthmatics and patients with non-atopic asthma had a higher sputum neutrophil count than did those with atopic asthma. Conclusions: Our data indicate that atopic asthmatics had an early onset of disease and high IgE levels, while the non-atopic asthmatics had decreased lung function and a high sputum neutrophil count, suggesting that a different approach is needed to treat atopic asthma.

AB - Purpose: Atopy is an important cause of asthma. Few data on the prevalence of atopy or comparisons with clinical characteristics of asthma in Korean patients have been published. We evaluated the effects of atopy on clinical profiles and airway inflammation in Korean asthmatics. Methods: We retrospectively enrolled 1,492 asthmatics from the Cohort for Reality and Evolution of Adult Asthma in Korea (COREA) cohort who had undergone skin prick tests for aeroallergens. The patients' clinical characteristics, lung function, PC20, and sputum and blood inflammatory cell counts were compared based on the presence or absence of atopy. Atopy was defined as one or more positive reactions (A/H ratio >1) on a skin prick test. Results: Among 11 aeroallergens, house dust mites (Dermatophagoides farinae and Dermatophagoides pteronyssinus) were the most prevalent cause of a positive skin prick test. As compared with non-atopic asthmatics, atopic asthmatics showed early onset of the disease. Atopic patients with asthma had a higher FEV1, FVC, and FEV1/FVC as compared with non-atopic patients with asthma. In addition, asthmatics without atopy had more uncontrolled asthma (P=0.001) and severe rhinitis (P<0.05) as compared with atopic asthmatics. Smoking, as measured in pack years, was higher in the non-atopic asthmatics than in the atopic asthmatics. The erythrocyte sedimentation rate was higher in non-atopic asthmatics than in the atopic asthmatics and patients with non-atopic asthma had a higher sputum neutrophil count than did those with atopic asthma. Conclusions: Our data indicate that atopic asthmatics had an early onset of disease and high IgE levels, while the non-atopic asthmatics had decreased lung function and a high sputum neutrophil count, suggesting that a different approach is needed to treat atopic asthma.

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