Impact of caveolin-1 expression on the prognosis of transitional cell carcinoma of the upper urinary tract

Sung Cho Dae, Hyunee Yim, Su Cho Kang, Joon Hong Sung, Hoon Cho Nam, Il Kim Sun, Soo Ahn Hyun, Joong Kim Se

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15 Citations (Scopus)

Abstract

This study aimed to investigate the relationship of caveolin-1 expression with prognosis in patients with transitional cell carcinoma of the upper urinary tract (TCC-UUT). Formalin-fixed, paraffin-embedded tissue sections of TCC-UUT from 98 patients, who had undergone radical nephroureterectomy, were stained immunohistochemically using antibodies against caveolin-1. The expression pattern of caveolin-1 was compared with the clinicopathological variables. The caveolin-1 expression was significantly correlated with T stage (p<0.001) and grade (p=0.036). The survival rate of patients with caveolin-1 positive tumors was significantly lower than that of patients with caveolin-1 negative tumors (p<0.0001). The univariate analyses identified T stage, grade, and caveolin-1 expression as significant prognostic factors for cancer-specific survival, whereas the multivariate analyses indicated that T stage and caveolin-1 expression were independent prognostic factors. These results show that the increased expression of caveolin-1 is associated with tumor progression and poor prognosis in TCC-UUT, suggesting that caveolin-1 may play an important role in the progression of TCC-UUT.

Original languageEnglish
Pages (from-to)296-301
Number of pages6
JournalJournal of Korean medical science
Volume23
Issue number2
DOIs
Publication statusPublished - 2008 Apr

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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