Abstract
This study aimed to investigate the relationship of caveolin-1 expression with prognosis in patients with transitional cell carcinoma of the upper urinary tract (TCC-UUT). Formalin-fixed, paraffin-embedded tissue sections of TCC-UUT from 98 patients, who had undergone radical nephroureterectomy, were stained immunohistochemically using antibodies against caveolin-1. The expression pattern of caveolin-1 was compared with the clinicopathological variables. The caveolin-1 expression was significantly correlated with T stage (p<0.001) and grade (p=0.036). The survival rate of patients with caveolin-1 positive tumors was significantly lower than that of patients with caveolin-1 negative tumors (p<0.0001). The univariate analyses identified T stage, grade, and caveolin-1 expression as significant prognostic factors for cancer-specific survival, whereas the multivariate analyses indicated that T stage and caveolin-1 expression were independent prognostic factors. These results show that the increased expression of caveolin-1 is associated with tumor progression and poor prognosis in TCC-UUT, suggesting that caveolin-1 may play an important role in the progression of TCC-UUT.
| Original language | English |
|---|---|
| Pages (from-to) | 296-301 |
| Number of pages | 6 |
| Journal | Journal of Korean medical science |
| Volume | 23 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2008 Apr 1 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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Impact of caveolin-1 expression on the prognosis of transitional cell carcinoma of the upper urinary tract. / Dae, Sung Cho; Yim, Hyunee; Kang, Su Cho; Sung, Joon Hong; Nam, Hoon Cho; Sun, Il Kim; Hyun, Soo Ahn; Se, Joong Kim.
In: Journal of Korean medical science, Vol. 23, No. 2, 01.04.2008, p. 296-301.Research output: Contribution to journal › Article
TY - JOUR
T1 - Impact of caveolin-1 expression on the prognosis of transitional cell carcinoma of the upper urinary tract
AU - Dae, Sung Cho
AU - Yim, Hyunee
AU - Kang, Su Cho
AU - Sung, Joon Hong
AU - Nam, Hoon Cho
AU - Sun, Il Kim
AU - Hyun, Soo Ahn
AU - Se, Joong Kim
PY - 2008/4/1
Y1 - 2008/4/1
N2 - This study aimed to investigate the relationship of caveolin-1 expression with prognosis in patients with transitional cell carcinoma of the upper urinary tract (TCC-UUT). Formalin-fixed, paraffin-embedded tissue sections of TCC-UUT from 98 patients, who had undergone radical nephroureterectomy, were stained immunohistochemically using antibodies against caveolin-1. The expression pattern of caveolin-1 was compared with the clinicopathological variables. The caveolin-1 expression was significantly correlated with T stage (p<0.001) and grade (p=0.036). The survival rate of patients with caveolin-1 positive tumors was significantly lower than that of patients with caveolin-1 negative tumors (p<0.0001). The univariate analyses identified T stage, grade, and caveolin-1 expression as significant prognostic factors for cancer-specific survival, whereas the multivariate analyses indicated that T stage and caveolin-1 expression were independent prognostic factors. These results show that the increased expression of caveolin-1 is associated with tumor progression and poor prognosis in TCC-UUT, suggesting that caveolin-1 may play an important role in the progression of TCC-UUT.
AB - This study aimed to investigate the relationship of caveolin-1 expression with prognosis in patients with transitional cell carcinoma of the upper urinary tract (TCC-UUT). Formalin-fixed, paraffin-embedded tissue sections of TCC-UUT from 98 patients, who had undergone radical nephroureterectomy, were stained immunohistochemically using antibodies against caveolin-1. The expression pattern of caveolin-1 was compared with the clinicopathological variables. The caveolin-1 expression was significantly correlated with T stage (p<0.001) and grade (p=0.036). The survival rate of patients with caveolin-1 positive tumors was significantly lower than that of patients with caveolin-1 negative tumors (p<0.0001). The univariate analyses identified T stage, grade, and caveolin-1 expression as significant prognostic factors for cancer-specific survival, whereas the multivariate analyses indicated that T stage and caveolin-1 expression were independent prognostic factors. These results show that the increased expression of caveolin-1 is associated with tumor progression and poor prognosis in TCC-UUT, suggesting that caveolin-1 may play an important role in the progression of TCC-UUT.
UR - http://www.scopus.com/inward/record.url?scp=43449093172&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=43449093172&partnerID=8YFLogxK
U2 - 10.3346/jkms.2008.23.2.296
DO - 10.3346/jkms.2008.23.2.296
M3 - Article
C2 - 18437015
AN - SCOPUS:43449093172
VL - 23
SP - 296
EP - 301
JO - Journal of Korean Medical Science
JF - Journal of Korean Medical Science
SN - 1011-8934
IS - 2
ER -