Impact of central haemodynamics on left ventricular function in individuals with an exaggerated blood pressure response to exercise

Chi Young Shim, Geu Ru Hong, Sungha Park, Woo In Yang, Donghoon Choi, Namsik Chung, Jong Won Ha

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

OBJECTIVE:: The impact of exaggerated blood pressure response (EBPR) to exercise on left ventricular function and the mechanism of its association are poorly understood. This study investigated the impact of arterial stiffening on left ventricular function in individuals with an EBPR to exercise. We hypothesized that individuals with low pulse pressure (PP) amplification during exercise would have worse left ventricular function than those with high PP amplification in individuals with an EBPR to exercise. METHODS:: Fifty-nine individuals with an EBPR to exercise (18 men, age 57±12 years) and 59 age and sex-matched controls were studied. Radial artery tonometry was performed at rest and immediately after exercise during supine bicycle exercise echocardiography. RESULTS:: There were no differences in left ventricular structure or function between individuals with an EBPR to exercise and controls. When individuals with an EBPR to exercise were divided into two groups on the basis of PP amplification after exercise [Group 1 (n=30), high PP amplification after exercise; Group 2 (n=29), low PP amplification after exercise], group 2 showed larger left atrial volume and lower early diastolic (e') and systolic (S') mitral annular velocities. Left ventricular apical rotation was also exaggerated in group 2. In multiple regression, PP amplification after exercise was an independent determinant of e' (β=0.16, P=0.019) and S' (β=0.25, P=0.009) in individuals with an EBPR to exercise. CONCLUSION:: In individuals with an EBPR to exercise, the degree of left ventricular dysfunction is variable. EBPR to exercise in the presence of arterial stiffening contributes to the deterioration of left ventricular function.

Original languageEnglish
Pages (from-to)612-620
Number of pages9
JournalJournal of Hypertension
Volume33
Issue number3
DOIs
Publication statusPublished - 2015 Mar 6

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Left Ventricular Function
Hemodynamics
Exercise
Blood Pressure
Radial Artery
Manometry
Left Ventricular Dysfunction
Echocardiography

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Impact of central haemodynamics on left ventricular function in individuals with an exaggerated blood pressure response to exercise",
abstract = "OBJECTIVE:: The impact of exaggerated blood pressure response (EBPR) to exercise on left ventricular function and the mechanism of its association are poorly understood. This study investigated the impact of arterial stiffening on left ventricular function in individuals with an EBPR to exercise. We hypothesized that individuals with low pulse pressure (PP) amplification during exercise would have worse left ventricular function than those with high PP amplification in individuals with an EBPR to exercise. METHODS:: Fifty-nine individuals with an EBPR to exercise (18 men, age 57±12 years) and 59 age and sex-matched controls were studied. Radial artery tonometry was performed at rest and immediately after exercise during supine bicycle exercise echocardiography. RESULTS:: There were no differences in left ventricular structure or function between individuals with an EBPR to exercise and controls. When individuals with an EBPR to exercise were divided into two groups on the basis of PP amplification after exercise [Group 1 (n=30), high PP amplification after exercise; Group 2 (n=29), low PP amplification after exercise], group 2 showed larger left atrial volume and lower early diastolic (e') and systolic (S') mitral annular velocities. Left ventricular apical rotation was also exaggerated in group 2. In multiple regression, PP amplification after exercise was an independent determinant of e' (β=0.16, P=0.019) and S' (β=0.25, P=0.009) in individuals with an EBPR to exercise. CONCLUSION:: In individuals with an EBPR to exercise, the degree of left ventricular dysfunction is variable. EBPR to exercise in the presence of arterial stiffening contributes to the deterioration of left ventricular function.",
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Impact of central haemodynamics on left ventricular function in individuals with an exaggerated blood pressure response to exercise. / Shim, Chi Young; Hong, Geu Ru; Park, Sungha; Yang, Woo In; Choi, Donghoon; Chung, Namsik; Ha, Jong Won.

In: Journal of Hypertension, Vol. 33, No. 3, 06.03.2015, p. 612-620.

Research output: Contribution to journalArticle

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T1 - Impact of central haemodynamics on left ventricular function in individuals with an exaggerated blood pressure response to exercise

AU - Shim, Chi Young

AU - Hong, Geu Ru

AU - Park, Sungha

AU - Yang, Woo In

AU - Choi, Donghoon

AU - Chung, Namsik

AU - Ha, Jong Won

PY - 2015/3/6

Y1 - 2015/3/6

N2 - OBJECTIVE:: The impact of exaggerated blood pressure response (EBPR) to exercise on left ventricular function and the mechanism of its association are poorly understood. This study investigated the impact of arterial stiffening on left ventricular function in individuals with an EBPR to exercise. We hypothesized that individuals with low pulse pressure (PP) amplification during exercise would have worse left ventricular function than those with high PP amplification in individuals with an EBPR to exercise. METHODS:: Fifty-nine individuals with an EBPR to exercise (18 men, age 57±12 years) and 59 age and sex-matched controls were studied. Radial artery tonometry was performed at rest and immediately after exercise during supine bicycle exercise echocardiography. RESULTS:: There were no differences in left ventricular structure or function between individuals with an EBPR to exercise and controls. When individuals with an EBPR to exercise were divided into two groups on the basis of PP amplification after exercise [Group 1 (n=30), high PP amplification after exercise; Group 2 (n=29), low PP amplification after exercise], group 2 showed larger left atrial volume and lower early diastolic (e') and systolic (S') mitral annular velocities. Left ventricular apical rotation was also exaggerated in group 2. In multiple regression, PP amplification after exercise was an independent determinant of e' (β=0.16, P=0.019) and S' (β=0.25, P=0.009) in individuals with an EBPR to exercise. CONCLUSION:: In individuals with an EBPR to exercise, the degree of left ventricular dysfunction is variable. EBPR to exercise in the presence of arterial stiffening contributes to the deterioration of left ventricular function.

AB - OBJECTIVE:: The impact of exaggerated blood pressure response (EBPR) to exercise on left ventricular function and the mechanism of its association are poorly understood. This study investigated the impact of arterial stiffening on left ventricular function in individuals with an EBPR to exercise. We hypothesized that individuals with low pulse pressure (PP) amplification during exercise would have worse left ventricular function than those with high PP amplification in individuals with an EBPR to exercise. METHODS:: Fifty-nine individuals with an EBPR to exercise (18 men, age 57±12 years) and 59 age and sex-matched controls were studied. Radial artery tonometry was performed at rest and immediately after exercise during supine bicycle exercise echocardiography. RESULTS:: There were no differences in left ventricular structure or function between individuals with an EBPR to exercise and controls. When individuals with an EBPR to exercise were divided into two groups on the basis of PP amplification after exercise [Group 1 (n=30), high PP amplification after exercise; Group 2 (n=29), low PP amplification after exercise], group 2 showed larger left atrial volume and lower early diastolic (e') and systolic (S') mitral annular velocities. Left ventricular apical rotation was also exaggerated in group 2. In multiple regression, PP amplification after exercise was an independent determinant of e' (β=0.16, P=0.019) and S' (β=0.25, P=0.009) in individuals with an EBPR to exercise. CONCLUSION:: In individuals with an EBPR to exercise, the degree of left ventricular dysfunction is variable. EBPR to exercise in the presence of arterial stiffening contributes to the deterioration of left ventricular function.

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JF - Journal of Hypertension

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