Impact of Cigarette Smoking on Living Kidney Donors

Y. E. Yoon, H. H. Lee, J. C. Na, K. H. Huh, M. S. Kim, S. I. Kim, YuSeun Kim, WoongKyu Han

Research output: Contribution to journalArticle

Abstract

Background: Smoking is known to result in a decline in renal allograft function and survival of recipients; however, the effect of smoking on living kidney donors remains unknown. In this study we evaluated the impact of cigarette smoking on renal function of kidney donors. Methods: Among 1056 donors who underwent nephrectomy, 612 completed the 6-month follow-up protocol and were enrolled in the study. The association of smoking status, including pack-years smoking history, and postoperative renal function was evaluated. Results: Among donors, 68.1% had never smoked, 8% were former smokers, and 23.9% were current smokers. Donors who never smoked were older than former and current smokers (42.3 ± 11.8, 41.9 ± 11.1, and 38.3 ± 10.9 years, respectively; P <.001). There was no difference in preoperative renal function between groups; however, postoperative estimated glomerular filtration rate (eGFR) was lower in former and current smokers than in those who never smoked (64.6 ± 13.8, 64.7 ± 12.3, and 67.8 ± 13.1 mL/min/1.73 m2, respectively; P =.023). In former and current smokers, pack-years smoking history was negatively associated with pre- and postoperative eGFR (r = -0.305 and -0.435, P <.001), and correlated with postoperative percent eGFR decline (r = 0.248, P <.001). Smoking history was associated with postoperative development of chronic kidney disease (CKD). Especially in former smokers, a smoking history of more than 12 pack-years was strongly associated with development of CKD (odds ratio = 7.5, P =.003). Conclusion: Even if they no longer smoke, donors with a smoking history require close observation due to increased risk of CKD development after kidney donation. A detailed pack-years smoking history should be obtained, and smoking cessation strategies should be implemented in kidney donors.

Original languageEnglish
Pages (from-to)1029-1033
Number of pages5
JournalTransplantation Proceedings
Volume50
Issue number4
DOIs
Publication statusPublished - 2018 May 1

Fingerprint

Living Donors
Smoking
Kidney
History
Glomerular Filtration Rate
Chronic Renal Insufficiency
Tissue Donors
Smoking Cessation
Nephrectomy
Smoke
Allografts
Odds Ratio
Observation

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

Cite this

Yoon, Y. E., Lee, H. H., Na, J. C., Huh, K. H., Kim, M. S., Kim, S. I., ... Han, W. (2018). Impact of Cigarette Smoking on Living Kidney Donors. Transplantation Proceedings, 50(4), 1029-1033. https://doi.org/10.1016/j.transproceed.2018.02.050
Yoon, Y. E. ; Lee, H. H. ; Na, J. C. ; Huh, K. H. ; Kim, M. S. ; Kim, S. I. ; Kim, YuSeun ; Han, WoongKyu. / Impact of Cigarette Smoking on Living Kidney Donors. In: Transplantation Proceedings. 2018 ; Vol. 50, No. 4. pp. 1029-1033.
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abstract = "Background: Smoking is known to result in a decline in renal allograft function and survival of recipients; however, the effect of smoking on living kidney donors remains unknown. In this study we evaluated the impact of cigarette smoking on renal function of kidney donors. Methods: Among 1056 donors who underwent nephrectomy, 612 completed the 6-month follow-up protocol and were enrolled in the study. The association of smoking status, including pack-years smoking history, and postoperative renal function was evaluated. Results: Among donors, 68.1{\%} had never smoked, 8{\%} were former smokers, and 23.9{\%} were current smokers. Donors who never smoked were older than former and current smokers (42.3 ± 11.8, 41.9 ± 11.1, and 38.3 ± 10.9 years, respectively; P <.001). There was no difference in preoperative renal function between groups; however, postoperative estimated glomerular filtration rate (eGFR) was lower in former and current smokers than in those who never smoked (64.6 ± 13.8, 64.7 ± 12.3, and 67.8 ± 13.1 mL/min/1.73 m2, respectively; P =.023). In former and current smokers, pack-years smoking history was negatively associated with pre- and postoperative eGFR (r = -0.305 and -0.435, P <.001), and correlated with postoperative percent eGFR decline (r = 0.248, P <.001). Smoking history was associated with postoperative development of chronic kidney disease (CKD). Especially in former smokers, a smoking history of more than 12 pack-years was strongly associated with development of CKD (odds ratio = 7.5, P =.003). Conclusion: Even if they no longer smoke, donors with a smoking history require close observation due to increased risk of CKD development after kidney donation. A detailed pack-years smoking history should be obtained, and smoking cessation strategies should be implemented in kidney donors.",
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Impact of Cigarette Smoking on Living Kidney Donors. / Yoon, Y. E.; Lee, H. H.; Na, J. C.; Huh, K. H.; Kim, M. S.; Kim, S. I.; Kim, YuSeun; Han, WoongKyu.

In: Transplantation Proceedings, Vol. 50, No. 4, 01.05.2018, p. 1029-1033.

Research output: Contribution to journalArticle

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T1 - Impact of Cigarette Smoking on Living Kidney Donors

AU - Yoon, Y. E.

AU - Lee, H. H.

AU - Na, J. C.

AU - Huh, K. H.

AU - Kim, M. S.

AU - Kim, S. I.

AU - Kim, YuSeun

AU - Han, WoongKyu

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N2 - Background: Smoking is known to result in a decline in renal allograft function and survival of recipients; however, the effect of smoking on living kidney donors remains unknown. In this study we evaluated the impact of cigarette smoking on renal function of kidney donors. Methods: Among 1056 donors who underwent nephrectomy, 612 completed the 6-month follow-up protocol and were enrolled in the study. The association of smoking status, including pack-years smoking history, and postoperative renal function was evaluated. Results: Among donors, 68.1% had never smoked, 8% were former smokers, and 23.9% were current smokers. Donors who never smoked were older than former and current smokers (42.3 ± 11.8, 41.9 ± 11.1, and 38.3 ± 10.9 years, respectively; P <.001). There was no difference in preoperative renal function between groups; however, postoperative estimated glomerular filtration rate (eGFR) was lower in former and current smokers than in those who never smoked (64.6 ± 13.8, 64.7 ± 12.3, and 67.8 ± 13.1 mL/min/1.73 m2, respectively; P =.023). In former and current smokers, pack-years smoking history was negatively associated with pre- and postoperative eGFR (r = -0.305 and -0.435, P <.001), and correlated with postoperative percent eGFR decline (r = 0.248, P <.001). Smoking history was associated with postoperative development of chronic kidney disease (CKD). Especially in former smokers, a smoking history of more than 12 pack-years was strongly associated with development of CKD (odds ratio = 7.5, P =.003). Conclusion: Even if they no longer smoke, donors with a smoking history require close observation due to increased risk of CKD development after kidney donation. A detailed pack-years smoking history should be obtained, and smoking cessation strategies should be implemented in kidney donors.

AB - Background: Smoking is known to result in a decline in renal allograft function and survival of recipients; however, the effect of smoking on living kidney donors remains unknown. In this study we evaluated the impact of cigarette smoking on renal function of kidney donors. Methods: Among 1056 donors who underwent nephrectomy, 612 completed the 6-month follow-up protocol and were enrolled in the study. The association of smoking status, including pack-years smoking history, and postoperative renal function was evaluated. Results: Among donors, 68.1% had never smoked, 8% were former smokers, and 23.9% were current smokers. Donors who never smoked were older than former and current smokers (42.3 ± 11.8, 41.9 ± 11.1, and 38.3 ± 10.9 years, respectively; P <.001). There was no difference in preoperative renal function between groups; however, postoperative estimated glomerular filtration rate (eGFR) was lower in former and current smokers than in those who never smoked (64.6 ± 13.8, 64.7 ± 12.3, and 67.8 ± 13.1 mL/min/1.73 m2, respectively; P =.023). In former and current smokers, pack-years smoking history was negatively associated with pre- and postoperative eGFR (r = -0.305 and -0.435, P <.001), and correlated with postoperative percent eGFR decline (r = 0.248, P <.001). Smoking history was associated with postoperative development of chronic kidney disease (CKD). Especially in former smokers, a smoking history of more than 12 pack-years was strongly associated with development of CKD (odds ratio = 7.5, P =.003). Conclusion: Even if they no longer smoke, donors with a smoking history require close observation due to increased risk of CKD development after kidney donation. A detailed pack-years smoking history should be obtained, and smoking cessation strategies should be implemented in kidney donors.

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Yoon YE, Lee HH, Na JC, Huh KH, Kim MS, Kim SI et al. Impact of Cigarette Smoking on Living Kidney Donors. Transplantation Proceedings. 2018 May 1;50(4):1029-1033. https://doi.org/10.1016/j.transproceed.2018.02.050