Impact of contrast-induced acute kidney injury with transient or persistent renal dysfunction on long-term outcomes of patients with acute myocardial infarction undergoing percutaneous coronary intervention

Jin Wi, Young Guk Ko, Jung Sun Kim, Byeong Keuk Kim, Donghoon Choi, Jong Won Ha, Myeong Ki Hong, Yangsoo Jang

Research output: Contribution to journalArticlepeer-review

115 Citations (Scopus)

Abstract

Objective: To investigate the long-term prognostic implications of contrast-induced acute kidney injury (CI-AKI) with transient or persistent renal dysfunction in acute myocardial infarction (AMI) patients undergoing percutaneous coronary intervention (PCI). Design: A retrospective observational registry study. Setting: Clinical follow-up after PCI. Patients and methods: A total of 1041 PCI-treated AMI patients from the Infarction Prognosis Study registry. CI-AKI was defined as an increase in serum creatinine (>25% or >0.5 mg/dl (>44.2 mmol/l)) within 2 days after PCI. Main outcome measures: Two-year cumulative event rate of all-cause death or renal failure requiring dialysis. Results: CI-AKI was observed in 148 patients (14.2%). Patients with CI-AKI had a higher rate of death or dialysis (25.4% vs 6.3%, p<0.001) at 2 years compared with patients without CI-AKI. CI-AKI was an important independent predictor of death or dialysis (HR 2.76, 95% CI 1.61 to 4.73, p<0.001) Persistent renal dysfunction after CI-AKI was documented in 68 patients (45.9%). Patients with transient renal dysfunction showed a lower 2-year event rate of death or dialysis compared with those with persistent renal dysfunction (17.9% vs 34.1%, p=0.013); however, they showed a higher event rate compared with those without CI-AKI (17.9% vs 6.3%, p<0.001). Conclusion: Transient and persistent renal dysfunction after CI-AKI was associated with increased short and long-term mortality and morbidity in AMI patients treated by PCI. Better preventive strategies are needed to improve clinical outcomes in AMI patients at high risk of developing CI-AKI.

Original languageEnglish
Pages (from-to)1753-1757
Number of pages5
JournalHeart
Volume97
Issue number21
DOIs
Publication statusPublished - 2011 Nov

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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