Impact of contrast-induced acute kidney injury with transient or persistent renal dysfunction on long-term outcomes of patients with acute myocardial infarction undergoing percutaneous coronary intervention

Jin Wi, Young Guk Ko, Jung Sun Kim, Byeong Keuk Kim, Donghoon Choi, Jong Won Ha, Myeong Ki Hong, Yangsoo Jang

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Objective: To investigate the long-term prognostic implications of contrast-induced acute kidney injury (CI-AKI) with transient or persistent renal dysfunction in acute myocardial infarction (AMI) patients undergoing percutaneous coronary intervention (PCI). Design: A retrospective observational registry study. Setting: Clinical follow-up after PCI. Patients and methods: A total of 1041 PCI-treated AMI patients from the Infarction Prognosis Study registry. CI-AKI was defined as an increase in serum creatinine (>25% or >0.5 mg/dl (>44.2 mmol/l)) within 2 days after PCI. Main outcome measures: Two-year cumulative event rate of all-cause death or renal failure requiring dialysis. Results: CI-AKI was observed in 148 patients (14.2%). Patients with CI-AKI had a higher rate of death or dialysis (25.4% vs 6.3%, p<0.001) at 2 years compared with patients without CI-AKI. CI-AKI was an important independent predictor of death or dialysis (HR 2.76, 95% CI 1.61 to 4.73, p<0.001) Persistent renal dysfunction after CI-AKI was documented in 68 patients (45.9%). Patients with transient renal dysfunction showed a lower 2-year event rate of death or dialysis compared with those with persistent renal dysfunction (17.9% vs 34.1%, p=0.013); however, they showed a higher event rate compared with those without CI-AKI (17.9% vs 6.3%, p<0.001). Conclusion: Transient and persistent renal dysfunction after CI-AKI was associated with increased short and long-term mortality and morbidity in AMI patients treated by PCI. Better preventive strategies are needed to improve clinical outcomes in AMI patients at high risk of developing CI-AKI.

Original languageEnglish
Pages (from-to)1753-1757
Number of pages5
JournalHeart
Volume97
Issue number21
DOIs
Publication statusPublished - 2011 Nov 1

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Percutaneous Coronary Intervention
Acute Kidney Injury
Myocardial Infarction
Kidney
Dialysis
Registries
Mortality
Infarction
Observational Studies
Renal Insufficiency
Cause of Death
Creatinine
Outcome Assessment (Health Care)
Morbidity

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

@article{f81740e0860545578523999e9bc1085f,
title = "Impact of contrast-induced acute kidney injury with transient or persistent renal dysfunction on long-term outcomes of patients with acute myocardial infarction undergoing percutaneous coronary intervention",
abstract = "Objective: To investigate the long-term prognostic implications of contrast-induced acute kidney injury (CI-AKI) with transient or persistent renal dysfunction in acute myocardial infarction (AMI) patients undergoing percutaneous coronary intervention (PCI). Design: A retrospective observational registry study. Setting: Clinical follow-up after PCI. Patients and methods: A total of 1041 PCI-treated AMI patients from the Infarction Prognosis Study registry. CI-AKI was defined as an increase in serum creatinine (>25{\%} or >0.5 mg/dl (>44.2 mmol/l)) within 2 days after PCI. Main outcome measures: Two-year cumulative event rate of all-cause death or renal failure requiring dialysis. Results: CI-AKI was observed in 148 patients (14.2{\%}). Patients with CI-AKI had a higher rate of death or dialysis (25.4{\%} vs 6.3{\%}, p<0.001) at 2 years compared with patients without CI-AKI. CI-AKI was an important independent predictor of death or dialysis (HR 2.76, 95{\%} CI 1.61 to 4.73, p<0.001) Persistent renal dysfunction after CI-AKI was documented in 68 patients (45.9{\%}). Patients with transient renal dysfunction showed a lower 2-year event rate of death or dialysis compared with those with persistent renal dysfunction (17.9{\%} vs 34.1{\%}, p=0.013); however, they showed a higher event rate compared with those without CI-AKI (17.9{\%} vs 6.3{\%}, p<0.001). Conclusion: Transient and persistent renal dysfunction after CI-AKI was associated with increased short and long-term mortality and morbidity in AMI patients treated by PCI. Better preventive strategies are needed to improve clinical outcomes in AMI patients at high risk of developing CI-AKI.",
author = "Jin Wi and Ko, {Young Guk} and Kim, {Jung Sun} and Kim, {Byeong Keuk} and Donghoon Choi and Ha, {Jong Won} and Hong, {Myeong Ki} and Yangsoo Jang",
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language = "English",
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journal = "Heart",
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Impact of contrast-induced acute kidney injury with transient or persistent renal dysfunction on long-term outcomes of patients with acute myocardial infarction undergoing percutaneous coronary intervention. / Wi, Jin; Ko, Young Guk; Kim, Jung Sun; Kim, Byeong Keuk; Choi, Donghoon; Ha, Jong Won; Hong, Myeong Ki; Jang, Yangsoo.

In: Heart, Vol. 97, No. 21, 01.11.2011, p. 1753-1757.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of contrast-induced acute kidney injury with transient or persistent renal dysfunction on long-term outcomes of patients with acute myocardial infarction undergoing percutaneous coronary intervention

AU - Wi, Jin

AU - Ko, Young Guk

AU - Kim, Jung Sun

AU - Kim, Byeong Keuk

AU - Choi, Donghoon

AU - Ha, Jong Won

AU - Hong, Myeong Ki

AU - Jang, Yangsoo

PY - 2011/11/1

Y1 - 2011/11/1

N2 - Objective: To investigate the long-term prognostic implications of contrast-induced acute kidney injury (CI-AKI) with transient or persistent renal dysfunction in acute myocardial infarction (AMI) patients undergoing percutaneous coronary intervention (PCI). Design: A retrospective observational registry study. Setting: Clinical follow-up after PCI. Patients and methods: A total of 1041 PCI-treated AMI patients from the Infarction Prognosis Study registry. CI-AKI was defined as an increase in serum creatinine (>25% or >0.5 mg/dl (>44.2 mmol/l)) within 2 days after PCI. Main outcome measures: Two-year cumulative event rate of all-cause death or renal failure requiring dialysis. Results: CI-AKI was observed in 148 patients (14.2%). Patients with CI-AKI had a higher rate of death or dialysis (25.4% vs 6.3%, p<0.001) at 2 years compared with patients without CI-AKI. CI-AKI was an important independent predictor of death or dialysis (HR 2.76, 95% CI 1.61 to 4.73, p<0.001) Persistent renal dysfunction after CI-AKI was documented in 68 patients (45.9%). Patients with transient renal dysfunction showed a lower 2-year event rate of death or dialysis compared with those with persistent renal dysfunction (17.9% vs 34.1%, p=0.013); however, they showed a higher event rate compared with those without CI-AKI (17.9% vs 6.3%, p<0.001). Conclusion: Transient and persistent renal dysfunction after CI-AKI was associated with increased short and long-term mortality and morbidity in AMI patients treated by PCI. Better preventive strategies are needed to improve clinical outcomes in AMI patients at high risk of developing CI-AKI.

AB - Objective: To investigate the long-term prognostic implications of contrast-induced acute kidney injury (CI-AKI) with transient or persistent renal dysfunction in acute myocardial infarction (AMI) patients undergoing percutaneous coronary intervention (PCI). Design: A retrospective observational registry study. Setting: Clinical follow-up after PCI. Patients and methods: A total of 1041 PCI-treated AMI patients from the Infarction Prognosis Study registry. CI-AKI was defined as an increase in serum creatinine (>25% or >0.5 mg/dl (>44.2 mmol/l)) within 2 days after PCI. Main outcome measures: Two-year cumulative event rate of all-cause death or renal failure requiring dialysis. Results: CI-AKI was observed in 148 patients (14.2%). Patients with CI-AKI had a higher rate of death or dialysis (25.4% vs 6.3%, p<0.001) at 2 years compared with patients without CI-AKI. CI-AKI was an important independent predictor of death or dialysis (HR 2.76, 95% CI 1.61 to 4.73, p<0.001) Persistent renal dysfunction after CI-AKI was documented in 68 patients (45.9%). Patients with transient renal dysfunction showed a lower 2-year event rate of death or dialysis compared with those with persistent renal dysfunction (17.9% vs 34.1%, p=0.013); however, they showed a higher event rate compared with those without CI-AKI (17.9% vs 6.3%, p<0.001). Conclusion: Transient and persistent renal dysfunction after CI-AKI was associated with increased short and long-term mortality and morbidity in AMI patients treated by PCI. Better preventive strategies are needed to improve clinical outcomes in AMI patients at high risk of developing CI-AKI.

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