TY - JOUR
T1 - Impact of coronary artery collaterals on infarct size assessed by serial cardiac magnetic resonance imaging after primary percutaneous coronary intervention in patients with acute myocardial infarction
AU - Yoon, Se Jung
AU - Ko, Young Guk
AU - Kim, Jung Sun
AU - Moon, Jae Youn
AU - Kim, Young Jin
AU - Park, Sungha
AU - Ha, Jong Won
AU - Choi, Donghoon
AU - Jang, Yangsoo
AU - Chung, Namsik
AU - Shim, Won Heum
AU - Cho, Seung Yun
PY - 2009/11
Y1 - 2009/11
N2 - Objectives: Coronary collaterals have been shown to protect ischemic myocardium from necrosis in patients with acute myocardial infarction (AMI). We sought to determine the impact of collateral circulation on infarct size in AMI using serial cardiac magnetic resonance (CMR). Methods: A total of 46 anterior AMI patients (age, 58.9±10.6 years; male 72.3%) undergoing primary percutaneous coronary intervention (PCI) were investigated. The infarct size was measured on serial CMR performed within 7 days after primary PCI (acute stage) and 3 months later (chronic stage). Results: Thirty-four patients (73.9%) showed collateral flow before primary PCI. CMR taken at the acute stage showed no significant difference in infarct size between two groups. However, follow-up CMR revealed significantly smaller percentage of infarct thickness (51.8±14.0 vs. 62.5±11.7%, P=0.035) and mass (22.3±9.9 vs. 30.9±11.6%, P=0.042) in patients with collaterals. There were significant changes from the acute to chronic stage regarding left ventricular end-systolic (-18.2±10.0 vs. 0.8±2.5ml, P=0.022) and end-diastolic volume (-14.8±9.2 vs. 2.6±13.7ml, P=0.031), percentage of infarct mass (-6.1±2.8 vs. -0.8±1.1%, P=0.034), and thickness (-8.9±3.3 vs. -3.1±2.8%, P=0.029) in collateral group compared with noncollateral group on serial CMR. Conclusion: Serial CMR revealed the effect of collaterals in patients with AMI on reduction of infarct size and improvement of myocardial remodeling at the chronic stage.
AB - Objectives: Coronary collaterals have been shown to protect ischemic myocardium from necrosis in patients with acute myocardial infarction (AMI). We sought to determine the impact of collateral circulation on infarct size in AMI using serial cardiac magnetic resonance (CMR). Methods: A total of 46 anterior AMI patients (age, 58.9±10.6 years; male 72.3%) undergoing primary percutaneous coronary intervention (PCI) were investigated. The infarct size was measured on serial CMR performed within 7 days after primary PCI (acute stage) and 3 months later (chronic stage). Results: Thirty-four patients (73.9%) showed collateral flow before primary PCI. CMR taken at the acute stage showed no significant difference in infarct size between two groups. However, follow-up CMR revealed significantly smaller percentage of infarct thickness (51.8±14.0 vs. 62.5±11.7%, P=0.035) and mass (22.3±9.9 vs. 30.9±11.6%, P=0.042) in patients with collaterals. There were significant changes from the acute to chronic stage regarding left ventricular end-systolic (-18.2±10.0 vs. 0.8±2.5ml, P=0.022) and end-diastolic volume (-14.8±9.2 vs. 2.6±13.7ml, P=0.031), percentage of infarct mass (-6.1±2.8 vs. -0.8±1.1%, P=0.034), and thickness (-8.9±3.3 vs. -3.1±2.8%, P=0.029) in collateral group compared with noncollateral group on serial CMR. Conclusion: Serial CMR revealed the effect of collaterals in patients with AMI on reduction of infarct size and improvement of myocardial remodeling at the chronic stage.
UR - http://www.scopus.com/inward/record.url?scp=70350774154&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350774154&partnerID=8YFLogxK
U2 - 10.1097/MCA.0b013e328330c930
DO - 10.1097/MCA.0b013e328330c930
M3 - Article
C2 - 19730371
AN - SCOPUS:70350774154
SN - 0954-6928
VL - 20
SP - 440
EP - 445
JO - Coronary Artery Disease
JF - Coronary Artery Disease
IS - 7
ER -