Impact of coronary artery collaterals on infarct size assessed by serial cardiac magnetic resonance imaging after primary percutaneous coronary intervention in patients with acute myocardial infarction

Se Jung Yoon, Young Guk Ko, Jung Sun Kim, Jae Youn Moon, Youngjin Kim, Sungha Park, Jong Won Ha, Donghoon Choi, Yangsoo Jang, Namsik Chung, Won Heum Shim, Seung Yun Cho

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objectives: Coronary collaterals have been shown to protect ischemic myocardium from necrosis in patients with acute myocardial infarction (AMI). We sought to determine the impact of collateral circulation on infarct size in AMI using serial cardiac magnetic resonance (CMR). Methods: A total of 46 anterior AMI patients (age, 58.9±10.6 years; male 72.3%) undergoing primary percutaneous coronary intervention (PCI) were investigated. The infarct size was measured on serial CMR performed within 7 days after primary PCI (acute stage) and 3 months later (chronic stage). Results: Thirty-four patients (73.9%) showed collateral flow before primary PCI. CMR taken at the acute stage showed no significant difference in infarct size between two groups. However, follow-up CMR revealed significantly smaller percentage of infarct thickness (51.8±14.0 vs. 62.5±11.7%, P=0.035) and mass (22.3±9.9 vs. 30.9±11.6%, P=0.042) in patients with collaterals. There were significant changes from the acute to chronic stage regarding left ventricular end-systolic (-18.2±10.0 vs. 0.8±2.5ml, P=0.022) and end-diastolic volume (-14.8±9.2 vs. 2.6±13.7ml, P=0.031), percentage of infarct mass (-6.1±2.8 vs. -0.8±1.1%, P=0.034), and thickness (-8.9±3.3 vs. -3.1±2.8%, P=0.029) in collateral group compared with noncollateral group on serial CMR. Conclusion: Serial CMR revealed the effect of collaterals in patients with AMI on reduction of infarct size and improvement of myocardial remodeling at the chronic stage.

Original languageEnglish
Pages (from-to)440-445
Number of pages6
JournalCoronary Artery Disease
Volume20
Issue number7
DOIs
Publication statusPublished - 2009 Nov 1

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Percutaneous Coronary Intervention
Coronary Vessels
Magnetic Resonance Spectroscopy
Myocardial Infarction
Magnetic Resonance Imaging
Collateral Circulation
Myocardium
Necrosis

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

@article{be9339a56f3e45cf98c50d225e6168f5,
title = "Impact of coronary artery collaterals on infarct size assessed by serial cardiac magnetic resonance imaging after primary percutaneous coronary intervention in patients with acute myocardial infarction",
abstract = "Objectives: Coronary collaterals have been shown to protect ischemic myocardium from necrosis in patients with acute myocardial infarction (AMI). We sought to determine the impact of collateral circulation on infarct size in AMI using serial cardiac magnetic resonance (CMR). Methods: A total of 46 anterior AMI patients (age, 58.9±10.6 years; male 72.3{\%}) undergoing primary percutaneous coronary intervention (PCI) were investigated. The infarct size was measured on serial CMR performed within 7 days after primary PCI (acute stage) and 3 months later (chronic stage). Results: Thirty-four patients (73.9{\%}) showed collateral flow before primary PCI. CMR taken at the acute stage showed no significant difference in infarct size between two groups. However, follow-up CMR revealed significantly smaller percentage of infarct thickness (51.8±14.0 vs. 62.5±11.7{\%}, P=0.035) and mass (22.3±9.9 vs. 30.9±11.6{\%}, P=0.042) in patients with collaterals. There were significant changes from the acute to chronic stage regarding left ventricular end-systolic (-18.2±10.0 vs. 0.8±2.5ml, P=0.022) and end-diastolic volume (-14.8±9.2 vs. 2.6±13.7ml, P=0.031), percentage of infarct mass (-6.1±2.8 vs. -0.8±1.1{\%}, P=0.034), and thickness (-8.9±3.3 vs. -3.1±2.8{\%}, P=0.029) in collateral group compared with noncollateral group on serial CMR. Conclusion: Serial CMR revealed the effect of collaterals in patients with AMI on reduction of infarct size and improvement of myocardial remodeling at the chronic stage.",
author = "Yoon, {Se Jung} and Ko, {Young Guk} and Kim, {Jung Sun} and Moon, {Jae Youn} and Youngjin Kim and Sungha Park and Ha, {Jong Won} and Donghoon Choi and Yangsoo Jang and Namsik Chung and Shim, {Won Heum} and Cho, {Seung Yun}",
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language = "English",
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pages = "440--445",
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}

Impact of coronary artery collaterals on infarct size assessed by serial cardiac magnetic resonance imaging after primary percutaneous coronary intervention in patients with acute myocardial infarction. / Yoon, Se Jung; Ko, Young Guk; Kim, Jung Sun; Moon, Jae Youn; Kim, Youngjin; Park, Sungha; Ha, Jong Won; Choi, Donghoon; Jang, Yangsoo; Chung, Namsik; Shim, Won Heum; Cho, Seung Yun.

In: Coronary Artery Disease, Vol. 20, No. 7, 01.11.2009, p. 440-445.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of coronary artery collaterals on infarct size assessed by serial cardiac magnetic resonance imaging after primary percutaneous coronary intervention in patients with acute myocardial infarction

AU - Yoon, Se Jung

AU - Ko, Young Guk

AU - Kim, Jung Sun

AU - Moon, Jae Youn

AU - Kim, Youngjin

AU - Park, Sungha

AU - Ha, Jong Won

AU - Choi, Donghoon

AU - Jang, Yangsoo

AU - Chung, Namsik

AU - Shim, Won Heum

AU - Cho, Seung Yun

PY - 2009/11/1

Y1 - 2009/11/1

N2 - Objectives: Coronary collaterals have been shown to protect ischemic myocardium from necrosis in patients with acute myocardial infarction (AMI). We sought to determine the impact of collateral circulation on infarct size in AMI using serial cardiac magnetic resonance (CMR). Methods: A total of 46 anterior AMI patients (age, 58.9±10.6 years; male 72.3%) undergoing primary percutaneous coronary intervention (PCI) were investigated. The infarct size was measured on serial CMR performed within 7 days after primary PCI (acute stage) and 3 months later (chronic stage). Results: Thirty-four patients (73.9%) showed collateral flow before primary PCI. CMR taken at the acute stage showed no significant difference in infarct size between two groups. However, follow-up CMR revealed significantly smaller percentage of infarct thickness (51.8±14.0 vs. 62.5±11.7%, P=0.035) and mass (22.3±9.9 vs. 30.9±11.6%, P=0.042) in patients with collaterals. There were significant changes from the acute to chronic stage regarding left ventricular end-systolic (-18.2±10.0 vs. 0.8±2.5ml, P=0.022) and end-diastolic volume (-14.8±9.2 vs. 2.6±13.7ml, P=0.031), percentage of infarct mass (-6.1±2.8 vs. -0.8±1.1%, P=0.034), and thickness (-8.9±3.3 vs. -3.1±2.8%, P=0.029) in collateral group compared with noncollateral group on serial CMR. Conclusion: Serial CMR revealed the effect of collaterals in patients with AMI on reduction of infarct size and improvement of myocardial remodeling at the chronic stage.

AB - Objectives: Coronary collaterals have been shown to protect ischemic myocardium from necrosis in patients with acute myocardial infarction (AMI). We sought to determine the impact of collateral circulation on infarct size in AMI using serial cardiac magnetic resonance (CMR). Methods: A total of 46 anterior AMI patients (age, 58.9±10.6 years; male 72.3%) undergoing primary percutaneous coronary intervention (PCI) were investigated. The infarct size was measured on serial CMR performed within 7 days after primary PCI (acute stage) and 3 months later (chronic stage). Results: Thirty-four patients (73.9%) showed collateral flow before primary PCI. CMR taken at the acute stage showed no significant difference in infarct size between two groups. However, follow-up CMR revealed significantly smaller percentage of infarct thickness (51.8±14.0 vs. 62.5±11.7%, P=0.035) and mass (22.3±9.9 vs. 30.9±11.6%, P=0.042) in patients with collaterals. There were significant changes from the acute to chronic stage regarding left ventricular end-systolic (-18.2±10.0 vs. 0.8±2.5ml, P=0.022) and end-diastolic volume (-14.8±9.2 vs. 2.6±13.7ml, P=0.031), percentage of infarct mass (-6.1±2.8 vs. -0.8±1.1%, P=0.034), and thickness (-8.9±3.3 vs. -3.1±2.8%, P=0.029) in collateral group compared with noncollateral group on serial CMR. Conclusion: Serial CMR revealed the effect of collaterals in patients with AMI on reduction of infarct size and improvement of myocardial remodeling at the chronic stage.

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