Impact of diabetes on treatment outcomes and long-term survival in multidrug-resistant tuberculosis

youngae kang, Song Yee Kim, Kyung Wook Jo, Hee Jin Kim, Seung Kyu Park, Tae Hyung Kim, Eun Kyung Kim, Ki Man Lee, Sung Soon Lee, Jae Seuk Park, Won Jung Koh, Dae Yun Kim, Tae Sun Shim

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Few studies have investigated the impact of diabetes mellitus (DM), a globally increasing metabolic disease, on treatment outcomes and long-term survival in patients with multidrug-resistant forms of tuberculosis (MDR-TB). Objectives: We analyzed outcomes in a large cohort to assess the impact of DM on treatment outcomes of patients with MDR-TB. Methods: MDR-TB patients newly diagnosed or retreated between 2000 and 2002 and followed for 8-11 years were retrospectively analyzed with respect to the effect of DM as a comorbidity on their treatment outcome and long-term survival. Results: Of 1,407 patients with MDR-TB, 239 (17.0%) had coexisting DM. The mean age and body mass index were higher in MDR-TB patients with DM [MDR-TBDM(+)] than in those without DM [MDR-TBDM(-)]. Patients with MDR-TB and a comorbidity of DM had a significantly lower treatment success rate than those without a history of DM (36.0 vs. 47.2%, p = 0.002). In addition, DM was the negative predictor for MDR-TB treatment success in multivariate analyses [odds ratio 0.51, 95% confidence interval (CI) 0.26-0.99]. Mean survival times were also lower in MDR-TBDM(+) than in MDR-TBDM(-) patients (102 vs. 114 months, p = 0.001), with DM as a significant predictor of poor long-term survival in multivariate analyses (hazard ratio 1.59, 95% CI 1.01-2.50). Conclusions: Among MDR-TB patients, DM was a relatively common comorbidity. In patients undergoing treatment for MDR-TB and followed for 8-11 years, it was found to be independently associated with an increased risk of both treatment failure and death.

Original languageEnglish
Pages (from-to)472-478
Number of pages7
JournalRespiration
Volume86
Issue number6
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Multidrug-Resistant Tuberculosis
Diabetes Mellitus
Survival
Comorbidity
Multivariate Analysis
Confidence Intervals
Metabolic Diseases
Treatment Failure
Body Mass Index
Therapeutics
Survival Rate
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

kang, Y., Kim, S. Y., Jo, K. W., Kim, H. J., Park, S. K., Kim, T. H., ... Shim, T. S. (2014). Impact of diabetes on treatment outcomes and long-term survival in multidrug-resistant tuberculosis. Respiration, 86(6), 472-478. https://doi.org/10.1159/000348374
kang, youngae ; Kim, Song Yee ; Jo, Kyung Wook ; Kim, Hee Jin ; Park, Seung Kyu ; Kim, Tae Hyung ; Kim, Eun Kyung ; Lee, Ki Man ; Lee, Sung Soon ; Park, Jae Seuk ; Koh, Won Jung ; Kim, Dae Yun ; Shim, Tae Sun. / Impact of diabetes on treatment outcomes and long-term survival in multidrug-resistant tuberculosis. In: Respiration. 2014 ; Vol. 86, No. 6. pp. 472-478.
@article{87cbbed568154921a01a490fb3739e44,
title = "Impact of diabetes on treatment outcomes and long-term survival in multidrug-resistant tuberculosis",
abstract = "Background: Few studies have investigated the impact of diabetes mellitus (DM), a globally increasing metabolic disease, on treatment outcomes and long-term survival in patients with multidrug-resistant forms of tuberculosis (MDR-TB). Objectives: We analyzed outcomes in a large cohort to assess the impact of DM on treatment outcomes of patients with MDR-TB. Methods: MDR-TB patients newly diagnosed or retreated between 2000 and 2002 and followed for 8-11 years were retrospectively analyzed with respect to the effect of DM as a comorbidity on their treatment outcome and long-term survival. Results: Of 1,407 patients with MDR-TB, 239 (17.0{\%}) had coexisting DM. The mean age and body mass index were higher in MDR-TB patients with DM [MDR-TBDM(+)] than in those without DM [MDR-TBDM(-)]. Patients with MDR-TB and a comorbidity of DM had a significantly lower treatment success rate than those without a history of DM (36.0 vs. 47.2{\%}, p = 0.002). In addition, DM was the negative predictor for MDR-TB treatment success in multivariate analyses [odds ratio 0.51, 95{\%} confidence interval (CI) 0.26-0.99]. Mean survival times were also lower in MDR-TBDM(+) than in MDR-TBDM(-) patients (102 vs. 114 months, p = 0.001), with DM as a significant predictor of poor long-term survival in multivariate analyses (hazard ratio 1.59, 95{\%} CI 1.01-2.50). Conclusions: Among MDR-TB patients, DM was a relatively common comorbidity. In patients undergoing treatment for MDR-TB and followed for 8-11 years, it was found to be independently associated with an increased risk of both treatment failure and death.",
author = "youngae kang and Kim, {Song Yee} and Jo, {Kyung Wook} and Kim, {Hee Jin} and Park, {Seung Kyu} and Kim, {Tae Hyung} and Kim, {Eun Kyung} and Lee, {Ki Man} and Lee, {Sung Soon} and Park, {Jae Seuk} and Koh, {Won Jung} and Kim, {Dae Yun} and Shim, {Tae Sun}",
year = "2014",
month = "1",
day = "1",
doi = "10.1159/000348374",
language = "English",
volume = "86",
pages = "472--478",
journal = "Respiration; international review of thoracic diseases",
issn = "0025-7931",
publisher = "S. Karger AG",
number = "6",

}

kang, Y, Kim, SY, Jo, KW, Kim, HJ, Park, SK, Kim, TH, Kim, EK, Lee, KM, Lee, SS, Park, JS, Koh, WJ, Kim, DY & Shim, TS 2014, 'Impact of diabetes on treatment outcomes and long-term survival in multidrug-resistant tuberculosis', Respiration, vol. 86, no. 6, pp. 472-478. https://doi.org/10.1159/000348374

Impact of diabetes on treatment outcomes and long-term survival in multidrug-resistant tuberculosis. / kang, youngae; Kim, Song Yee; Jo, Kyung Wook; Kim, Hee Jin; Park, Seung Kyu; Kim, Tae Hyung; Kim, Eun Kyung; Lee, Ki Man; Lee, Sung Soon; Park, Jae Seuk; Koh, Won Jung; Kim, Dae Yun; Shim, Tae Sun.

In: Respiration, Vol. 86, No. 6, 01.01.2014, p. 472-478.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of diabetes on treatment outcomes and long-term survival in multidrug-resistant tuberculosis

AU - kang, youngae

AU - Kim, Song Yee

AU - Jo, Kyung Wook

AU - Kim, Hee Jin

AU - Park, Seung Kyu

AU - Kim, Tae Hyung

AU - Kim, Eun Kyung

AU - Lee, Ki Man

AU - Lee, Sung Soon

AU - Park, Jae Seuk

AU - Koh, Won Jung

AU - Kim, Dae Yun

AU - Shim, Tae Sun

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: Few studies have investigated the impact of diabetes mellitus (DM), a globally increasing metabolic disease, on treatment outcomes and long-term survival in patients with multidrug-resistant forms of tuberculosis (MDR-TB). Objectives: We analyzed outcomes in a large cohort to assess the impact of DM on treatment outcomes of patients with MDR-TB. Methods: MDR-TB patients newly diagnosed or retreated between 2000 and 2002 and followed for 8-11 years were retrospectively analyzed with respect to the effect of DM as a comorbidity on their treatment outcome and long-term survival. Results: Of 1,407 patients with MDR-TB, 239 (17.0%) had coexisting DM. The mean age and body mass index were higher in MDR-TB patients with DM [MDR-TBDM(+)] than in those without DM [MDR-TBDM(-)]. Patients with MDR-TB and a comorbidity of DM had a significantly lower treatment success rate than those without a history of DM (36.0 vs. 47.2%, p = 0.002). In addition, DM was the negative predictor for MDR-TB treatment success in multivariate analyses [odds ratio 0.51, 95% confidence interval (CI) 0.26-0.99]. Mean survival times were also lower in MDR-TBDM(+) than in MDR-TBDM(-) patients (102 vs. 114 months, p = 0.001), with DM as a significant predictor of poor long-term survival in multivariate analyses (hazard ratio 1.59, 95% CI 1.01-2.50). Conclusions: Among MDR-TB patients, DM was a relatively common comorbidity. In patients undergoing treatment for MDR-TB and followed for 8-11 years, it was found to be independently associated with an increased risk of both treatment failure and death.

AB - Background: Few studies have investigated the impact of diabetes mellitus (DM), a globally increasing metabolic disease, on treatment outcomes and long-term survival in patients with multidrug-resistant forms of tuberculosis (MDR-TB). Objectives: We analyzed outcomes in a large cohort to assess the impact of DM on treatment outcomes of patients with MDR-TB. Methods: MDR-TB patients newly diagnosed or retreated between 2000 and 2002 and followed for 8-11 years were retrospectively analyzed with respect to the effect of DM as a comorbidity on their treatment outcome and long-term survival. Results: Of 1,407 patients with MDR-TB, 239 (17.0%) had coexisting DM. The mean age and body mass index were higher in MDR-TB patients with DM [MDR-TBDM(+)] than in those without DM [MDR-TBDM(-)]. Patients with MDR-TB and a comorbidity of DM had a significantly lower treatment success rate than those without a history of DM (36.0 vs. 47.2%, p = 0.002). In addition, DM was the negative predictor for MDR-TB treatment success in multivariate analyses [odds ratio 0.51, 95% confidence interval (CI) 0.26-0.99]. Mean survival times were also lower in MDR-TBDM(+) than in MDR-TBDM(-) patients (102 vs. 114 months, p = 0.001), with DM as a significant predictor of poor long-term survival in multivariate analyses (hazard ratio 1.59, 95% CI 1.01-2.50). Conclusions: Among MDR-TB patients, DM was a relatively common comorbidity. In patients undergoing treatment for MDR-TB and followed for 8-11 years, it was found to be independently associated with an increased risk of both treatment failure and death.

UR - http://www.scopus.com/inward/record.url?scp=84893698526&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893698526&partnerID=8YFLogxK

U2 - 10.1159/000348374

DO - 10.1159/000348374

M3 - Article

VL - 86

SP - 472

EP - 478

JO - Respiration; international review of thoracic diseases

JF - Respiration; international review of thoracic diseases

SN - 0025-7931

IS - 6

ER -