Impact of different synthetic bone fillers on healing of extraction sockets: An experimental study in dogs

Ji Youn Hong, Jung Seok Lee, Eun Kyoung Pang, Ui Won Jung, Seong Ho Choi, Chong Kwan Kim

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Objectives: The objective of this study was to elucidate the socket healing process and biodegradation of incorporating synthetic bone fillers followed by grafting of the fresh extraction socket. Materials and methods: Third premolars in four quadrants of eight beagle dogs were extracted and randomly treated with either one of hydroxyapatite (HA), biphasic calcium phosphate (BCP), β-tricalcium phosphate (β-TCP), or no graft (C). Histologic observations and histomorphometric analysis at three zones (apical, middle, and coronal) of the socket were performed. Socket area (S) and the proportions of newly formed bone (%NB), residual biomaterials (%RB), and fibrovascular connective tissue (%FCT) at 2, 4, and 8 weeks were measured. The numbers of osteoclast-like multinucleated cells (No.OC) were also determined at the three zones. Results: %NB was significantly higher in control group compared with the grafted groups at all healing periods. %NB of HA and BCP increased with time, whereas %RB showed different patterns that decreased in BCP, unlike the minimal change observed in HA. %NB of β-TCP showed smallest portion compared with other grafted groups at 2 and 4 weeks, however, significantly increased at 8 weeks. %RB of β-TCP was less than HA and BCP at all healing periods. Numbers of multinucleated cells were greater in BCP and β-TCP, followed by HA and smallest in control group. Conclusions: Within the limit of this study, bone formation of the extraction socket was delayed in the sockets grafted with synthetic bone fillers and showed different healing process according to the biodegradation patterns.

Original languageEnglish
JournalClinical Oral Implants Research
Volume25
Issue number2
DOIs
Publication statusPublished - 2014 Feb 1

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Durapatite
Dogs
Bone and Bones
Control Groups
Bicuspid
Biocompatible Materials
Osteoclasts
Osteogenesis
Connective Tissue
Cell Count
hydroxyapatite-beta tricalcium phosphate
Transplants

All Science Journal Classification (ASJC) codes

  • Oral Surgery
  • Medicine(all)

Cite this

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title = "Impact of different synthetic bone fillers on healing of extraction sockets: An experimental study in dogs",
abstract = "Objectives: The objective of this study was to elucidate the socket healing process and biodegradation of incorporating synthetic bone fillers followed by grafting of the fresh extraction socket. Materials and methods: Third premolars in four quadrants of eight beagle dogs were extracted and randomly treated with either one of hydroxyapatite (HA), biphasic calcium phosphate (BCP), β-tricalcium phosphate (β-TCP), or no graft (C). Histologic observations and histomorphometric analysis at three zones (apical, middle, and coronal) of the socket were performed. Socket area (S) and the proportions of newly formed bone ({\%}NB), residual biomaterials ({\%}RB), and fibrovascular connective tissue ({\%}FCT) at 2, 4, and 8 weeks were measured. The numbers of osteoclast-like multinucleated cells (No.OC) were also determined at the three zones. Results: {\%}NB was significantly higher in control group compared with the grafted groups at all healing periods. {\%}NB of HA and BCP increased with time, whereas {\%}RB showed different patterns that decreased in BCP, unlike the minimal change observed in HA. {\%}NB of β-TCP showed smallest portion compared with other grafted groups at 2 and 4 weeks, however, significantly increased at 8 weeks. {\%}RB of β-TCP was less than HA and BCP at all healing periods. Numbers of multinucleated cells were greater in BCP and β-TCP, followed by HA and smallest in control group. Conclusions: Within the limit of this study, bone formation of the extraction socket was delayed in the sockets grafted with synthetic bone fillers and showed different healing process according to the biodegradation patterns.",
author = "Hong, {Ji Youn} and Lee, {Jung Seok} and Pang, {Eun Kyoung} and Jung, {Ui Won} and Choi, {Seong Ho} and Kim, {Chong Kwan}",
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Impact of different synthetic bone fillers on healing of extraction sockets : An experimental study in dogs. / Hong, Ji Youn; Lee, Jung Seok; Pang, Eun Kyoung; Jung, Ui Won; Choi, Seong Ho; Kim, Chong Kwan.

In: Clinical Oral Implants Research, Vol. 25, No. 2, 01.02.2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of different synthetic bone fillers on healing of extraction sockets

T2 - An experimental study in dogs

AU - Hong, Ji Youn

AU - Lee, Jung Seok

AU - Pang, Eun Kyoung

AU - Jung, Ui Won

AU - Choi, Seong Ho

AU - Kim, Chong Kwan

PY - 2014/2/1

Y1 - 2014/2/1

N2 - Objectives: The objective of this study was to elucidate the socket healing process and biodegradation of incorporating synthetic bone fillers followed by grafting of the fresh extraction socket. Materials and methods: Third premolars in four quadrants of eight beagle dogs were extracted and randomly treated with either one of hydroxyapatite (HA), biphasic calcium phosphate (BCP), β-tricalcium phosphate (β-TCP), or no graft (C). Histologic observations and histomorphometric analysis at three zones (apical, middle, and coronal) of the socket were performed. Socket area (S) and the proportions of newly formed bone (%NB), residual biomaterials (%RB), and fibrovascular connective tissue (%FCT) at 2, 4, and 8 weeks were measured. The numbers of osteoclast-like multinucleated cells (No.OC) were also determined at the three zones. Results: %NB was significantly higher in control group compared with the grafted groups at all healing periods. %NB of HA and BCP increased with time, whereas %RB showed different patterns that decreased in BCP, unlike the minimal change observed in HA. %NB of β-TCP showed smallest portion compared with other grafted groups at 2 and 4 weeks, however, significantly increased at 8 weeks. %RB of β-TCP was less than HA and BCP at all healing periods. Numbers of multinucleated cells were greater in BCP and β-TCP, followed by HA and smallest in control group. Conclusions: Within the limit of this study, bone formation of the extraction socket was delayed in the sockets grafted with synthetic bone fillers and showed different healing process according to the biodegradation patterns.

AB - Objectives: The objective of this study was to elucidate the socket healing process and biodegradation of incorporating synthetic bone fillers followed by grafting of the fresh extraction socket. Materials and methods: Third premolars in four quadrants of eight beagle dogs were extracted and randomly treated with either one of hydroxyapatite (HA), biphasic calcium phosphate (BCP), β-tricalcium phosphate (β-TCP), or no graft (C). Histologic observations and histomorphometric analysis at three zones (apical, middle, and coronal) of the socket were performed. Socket area (S) and the proportions of newly formed bone (%NB), residual biomaterials (%RB), and fibrovascular connective tissue (%FCT) at 2, 4, and 8 weeks were measured. The numbers of osteoclast-like multinucleated cells (No.OC) were also determined at the three zones. Results: %NB was significantly higher in control group compared with the grafted groups at all healing periods. %NB of HA and BCP increased with time, whereas %RB showed different patterns that decreased in BCP, unlike the minimal change observed in HA. %NB of β-TCP showed smallest portion compared with other grafted groups at 2 and 4 weeks, however, significantly increased at 8 weeks. %RB of β-TCP was less than HA and BCP at all healing periods. Numbers of multinucleated cells were greater in BCP and β-TCP, followed by HA and smallest in control group. Conclusions: Within the limit of this study, bone formation of the extraction socket was delayed in the sockets grafted with synthetic bone fillers and showed different healing process according to the biodegradation patterns.

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DO - 10.1111/clr.12041

M3 - Article

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