Impact of environmental tobacco smoke on the incidence of mutations in epidermal growth factor receptor gene in never-smoker patients with non-small-cell lung cancer

Young Joo Lee, Byoung Chul Cho, Sun Ha Jee, Jin Wook Moon, Se Kyu Kim, Joon Chang, Kyung Young Chung, In Kyu Park, Sung Ho Choi, Joo Hang Kim

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Purpose: Active tobacco smoking has been associated with the incidence of epidermal growth factor receptor (EGFR) mutations. However, the impact of environmental tobacco smoke (ETS) on EGFR mutations has been unknown. We investigated an association between ETS exposure and EGFR mutations in never smokers with non-small-cell lung cancer (NSCLC). Patients and Methods: We enrolled 179 consecutive never smokers who were newly diagnosed with NSCLC. The history of ETS exposure was obtained with a standardized questionnaire that included exposure period, place, and duration. The nucleotide sequences of exons 18 to 21 on EGFR gene were determined using nested polymerase chain reaction amplification. Results: The incidence of EGFR mutations was significantly lower in patients with ETS exposure than in those without (38.5% v 61.4%; P = .008). In a logistic regression model that adjusted for sex and histology, an adjusted odds ratio (AOR) for the risk of EGFR mutations with exposure to ETS was 0.40 (95% CI, 0.20 to 0.81; P = .011). In quartile groups based on total smoker-year, the AORs for the lowest- to highest-quartile groups were 0.59 (95% CI, 0.23 to 1.49), 0.50 (95% CI, 0.17 to 1.50), 0.48 (95% CI, 0.20 to 1.18), and 0.22 (95% CI, 0.08 to 0.62; Ptrend = .028). Among the types of ETS exposure, adulthood ETS and household ETS were significantly associated with the incidence of EGFR mutations. Patients with ETS exposure showed a lower response rate to EGFR tyrosine kinase inhibitors than did patients without ETS exposure (24.6% v 44.8%; P = .053). Conclusion: ETS exposure is negatively associated with EGFR mutations in never smokers with NSCLC.

Original languageEnglish
Pages (from-to)487-492
Number of pages6
JournalJournal of Clinical Oncology
Volume28
Issue number3
DOIs
Publication statusPublished - 2010 Jan 20

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erbB-1 Genes
Non-Small Cell Lung Carcinoma
Smoke
Tobacco
Epidermal Growth Factor Receptor
Mutation
Incidence
Environmental Exposure
Logistic Models
Protein-Tyrosine Kinases
Exons
Histology
Smoking
History
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Lee, Young Joo ; Cho, Byoung Chul ; Jee, Sun Ha ; Moon, Jin Wook ; Kim, Se Kyu ; Chang, Joon ; Chung, Kyung Young ; Park, In Kyu ; Choi, Sung Ho ; Kim, Joo Hang. / Impact of environmental tobacco smoke on the incidence of mutations in epidermal growth factor receptor gene in never-smoker patients with non-small-cell lung cancer. In: Journal of Clinical Oncology. 2010 ; Vol. 28, No. 3. pp. 487-492.
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title = "Impact of environmental tobacco smoke on the incidence of mutations in epidermal growth factor receptor gene in never-smoker patients with non-small-cell lung cancer",
abstract = "Purpose: Active tobacco smoking has been associated with the incidence of epidermal growth factor receptor (EGFR) mutations. However, the impact of environmental tobacco smoke (ETS) on EGFR mutations has been unknown. We investigated an association between ETS exposure and EGFR mutations in never smokers with non-small-cell lung cancer (NSCLC). Patients and Methods: We enrolled 179 consecutive never smokers who were newly diagnosed with NSCLC. The history of ETS exposure was obtained with a standardized questionnaire that included exposure period, place, and duration. The nucleotide sequences of exons 18 to 21 on EGFR gene were determined using nested polymerase chain reaction amplification. Results: The incidence of EGFR mutations was significantly lower in patients with ETS exposure than in those without (38.5{\%} v 61.4{\%}; P = .008). In a logistic regression model that adjusted for sex and histology, an adjusted odds ratio (AOR) for the risk of EGFR mutations with exposure to ETS was 0.40 (95{\%} CI, 0.20 to 0.81; P = .011). In quartile groups based on total smoker-year, the AORs for the lowest- to highest-quartile groups were 0.59 (95{\%} CI, 0.23 to 1.49), 0.50 (95{\%} CI, 0.17 to 1.50), 0.48 (95{\%} CI, 0.20 to 1.18), and 0.22 (95{\%} CI, 0.08 to 0.62; Ptrend = .028). Among the types of ETS exposure, adulthood ETS and household ETS were significantly associated with the incidence of EGFR mutations. Patients with ETS exposure showed a lower response rate to EGFR tyrosine kinase inhibitors than did patients without ETS exposure (24.6{\%} v 44.8{\%}; P = .053). Conclusion: ETS exposure is negatively associated with EGFR mutations in never smokers with NSCLC.",
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Impact of environmental tobacco smoke on the incidence of mutations in epidermal growth factor receptor gene in never-smoker patients with non-small-cell lung cancer. / Lee, Young Joo; Cho, Byoung Chul; Jee, Sun Ha; Moon, Jin Wook; Kim, Se Kyu; Chang, Joon; Chung, Kyung Young; Park, In Kyu; Choi, Sung Ho; Kim, Joo Hang.

In: Journal of Clinical Oncology, Vol. 28, No. 3, 20.01.2010, p. 487-492.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of environmental tobacco smoke on the incidence of mutations in epidermal growth factor receptor gene in never-smoker patients with non-small-cell lung cancer

AU - Lee, Young Joo

AU - Cho, Byoung Chul

AU - Jee, Sun Ha

AU - Moon, Jin Wook

AU - Kim, Se Kyu

AU - Chang, Joon

AU - Chung, Kyung Young

AU - Park, In Kyu

AU - Choi, Sung Ho

AU - Kim, Joo Hang

PY - 2010/1/20

Y1 - 2010/1/20

N2 - Purpose: Active tobacco smoking has been associated with the incidence of epidermal growth factor receptor (EGFR) mutations. However, the impact of environmental tobacco smoke (ETS) on EGFR mutations has been unknown. We investigated an association between ETS exposure and EGFR mutations in never smokers with non-small-cell lung cancer (NSCLC). Patients and Methods: We enrolled 179 consecutive never smokers who were newly diagnosed with NSCLC. The history of ETS exposure was obtained with a standardized questionnaire that included exposure period, place, and duration. The nucleotide sequences of exons 18 to 21 on EGFR gene were determined using nested polymerase chain reaction amplification. Results: The incidence of EGFR mutations was significantly lower in patients with ETS exposure than in those without (38.5% v 61.4%; P = .008). In a logistic regression model that adjusted for sex and histology, an adjusted odds ratio (AOR) for the risk of EGFR mutations with exposure to ETS was 0.40 (95% CI, 0.20 to 0.81; P = .011). In quartile groups based on total smoker-year, the AORs for the lowest- to highest-quartile groups were 0.59 (95% CI, 0.23 to 1.49), 0.50 (95% CI, 0.17 to 1.50), 0.48 (95% CI, 0.20 to 1.18), and 0.22 (95% CI, 0.08 to 0.62; Ptrend = .028). Among the types of ETS exposure, adulthood ETS and household ETS were significantly associated with the incidence of EGFR mutations. Patients with ETS exposure showed a lower response rate to EGFR tyrosine kinase inhibitors than did patients without ETS exposure (24.6% v 44.8%; P = .053). Conclusion: ETS exposure is negatively associated with EGFR mutations in never smokers with NSCLC.

AB - Purpose: Active tobacco smoking has been associated with the incidence of epidermal growth factor receptor (EGFR) mutations. However, the impact of environmental tobacco smoke (ETS) on EGFR mutations has been unknown. We investigated an association between ETS exposure and EGFR mutations in never smokers with non-small-cell lung cancer (NSCLC). Patients and Methods: We enrolled 179 consecutive never smokers who were newly diagnosed with NSCLC. The history of ETS exposure was obtained with a standardized questionnaire that included exposure period, place, and duration. The nucleotide sequences of exons 18 to 21 on EGFR gene were determined using nested polymerase chain reaction amplification. Results: The incidence of EGFR mutations was significantly lower in patients with ETS exposure than in those without (38.5% v 61.4%; P = .008). In a logistic regression model that adjusted for sex and histology, an adjusted odds ratio (AOR) for the risk of EGFR mutations with exposure to ETS was 0.40 (95% CI, 0.20 to 0.81; P = .011). In quartile groups based on total smoker-year, the AORs for the lowest- to highest-quartile groups were 0.59 (95% CI, 0.23 to 1.49), 0.50 (95% CI, 0.17 to 1.50), 0.48 (95% CI, 0.20 to 1.18), and 0.22 (95% CI, 0.08 to 0.62; Ptrend = .028). Among the types of ETS exposure, adulthood ETS and household ETS were significantly associated with the incidence of EGFR mutations. Patients with ETS exposure showed a lower response rate to EGFR tyrosine kinase inhibitors than did patients without ETS exposure (24.6% v 44.8%; P = .053). Conclusion: ETS exposure is negatively associated with EGFR mutations in never smokers with NSCLC.

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