Impact of genetic variants on clinical outcome after percutaneous coronary intervention in elderly patients

Jung Joon Cha, Jae Hyoung Park, Hyung Joon Joo, Soon Jun Hong, Tae Hoon Ahn, Byeong Keuk Kim, Won Yong Shin, Sung Gyun Ahn, Jung Han Yoon, Yong Hoon Kim, Yun Hyeong cho, Woong Chol Kang, Weon Kim, Young Hyo Lim, Hyeon Cheol Gwon, Woong Gil Choi, Do Sun Lim

Research output: Contribution to journalArticlepeer-review

Abstract

Elderly patients treated with percutaneous coronary intervention (PCI) have a higher risk of both ischemic and bleeding complications than younger patients. However, few studies have reported how genetic information of elderly patients treated with PCI affects clinical outcomes. We investigated the impact of genetic variants on clinical outcomes in elderly patients. Correlations between single-nucleotide polymorphisms (CYP2C19 and P2Y12 receptor gene G52T polymorphism) and clinical outcomes were analyzed in 811 elderly patients (≥75 years of age) from a prospective multicenter registry. The primary endpoint was a composite of myocardial infarction and death. Secondary endpoints were an individual event of death, cardiac death, myocardial

Original languageEnglish
Pages (from-to)6506-6517
Number of pages12
JournalAging
Volume13
Issue number5
DOIs
Publication statusPublished - 2021 Mar 15

Bibliographical note

Funding Information:
This work was supported by Dong-A ST Co., Ltd. All authors declare that the funders had no role in the study design, data collection and analysis, preparation of the manuscript, or decision to publish.

Publisher Copyright:
© 2021 Cha et al. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Ageing
  • Cell Biology

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