Impact of grade, hormone receptor, and HER-2 status in women with breast cancer on response to specific chemotherapeutic agents by in vitro adenosine triphosphate-based chemotherapy response assay

Ja Seung Koo, Woohee Jung, Eunah Shin, Hy de Lee, Joon Jeong, Kun Hong Kim, Hyeongjae Jeong, Soon Won Hong

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

This study was designed to assess whether histological and biological factors of breast cancer can predict chemoresponse to specific agents. Adenosine triphosphate-based chemotherapy response assay (ATP-CRA) was employed to retrieve chemoresponse to 5-fluorouracil (5-FU), doxetaxel, doxorubicin, epirubicin, and paclitaxel in 49 patients. Tumors with high histologic and nuclear grade have higher response rate to doxorubicin (P<0.05) and palitaxel (P<0.05). Estrogen receptor (ER)-negative tumors respond well to doxorubicin (P=0.038), and progesterone receptor (PR)-negative tumors to 5-FU (P=0.039), doxetaxel (P=0.038), doxorubicin (P=0.000), epirubicin (P=0.010), and paclitaxel (P=0.003). Among the breast cancer subtypes determined by ER, PR, and HER-2 immunohistochemical stains, the HER-2+/ER subtype has a higher response rate to doxorubicin (P=0.008). This in vitro result suggests that the combination of histologic and nuclear grade, hormone receptor, and HER-2 sta tus can be a predictive factor of response to specific chemotherapy agents. Further in vivo study should be followed for clinical trials.

Original languageEnglish
Pages (from-to)1150-1157
Number of pages8
JournalJournal of Korean medical science
Volume24
Issue number6
DOIs
Publication statusPublished - 2009 Dec

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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