Impact of grade, hormone receptor, and HER-2 status in women with breast cancer on response to specific chemotherapeutic agents by in vitro adenosine triphosphate-based chemotherapy response assay

Ja Seung Koo, Woohee Jung, Eunah Shin, Hy de Lee, Joon Jeong, Kun Hong Kim, Hyeongjae Jeong, Soon Won Hong

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

This study was designed to assess whether histological and biological factors of breast cancer can predict chemoresponse to specific agents. Adenosine triphosphate-based chemotherapy response assay (ATP-CRA) was employed to retrieve chemoresponse to 5-fluorouracil (5-FU), doxetaxel, doxorubicin, epirubicin, and paclitaxel in 49 patients. Tumors with high histologic and nuclear grade have higher response rate to doxorubicin (P<0.05) and palitaxel (P<0.05). Estrogen receptor (ER)-negative tumors respond well to doxorubicin (P=0.038), and progesterone receptor (PR)-negative tumors to 5-FU (P=0.039), doxetaxel (P=0.038), doxorubicin (P=0.000), epirubicin (P=0.010), and paclitaxel (P=0.003). Among the breast cancer subtypes determined by ER, PR, and HER-2 immunohistochemical stains, the HER-2+/ER subtype has a higher response rate to doxorubicin (P=0.008). This in vitro result suggests that the combination of histologic and nuclear grade, hormone receptor, and HER-2 sta tus can be a predictive factor of response to specific chemotherapy agents. Further in vivo study should be followed for clinical trials.

Original languageEnglish
Pages (from-to)1150-1157
Number of pages8
JournalJournal of Korean medical science
Volume24
Issue number6
DOIs
Publication statusPublished - 2009 Dec 1

Fingerprint

Women's Rights
Doxorubicin
Adenosine Triphosphate
Hormones
Breast Neoplasms
Drug Therapy
Estrogen Receptors
Epirubicin
Progesterone Receptors
Paclitaxel
Fluorouracil
Neoplasms
Biological Factors
Cytoplasmic and Nuclear Receptors
Coloring Agents
In Vitro Techniques
Clinical Trials

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{603179f0466e479aa6afd953f671f292,
title = "Impact of grade, hormone receptor, and HER-2 status in women with breast cancer on response to specific chemotherapeutic agents by in vitro adenosine triphosphate-based chemotherapy response assay",
abstract = "This study was designed to assess whether histological and biological factors of breast cancer can predict chemoresponse to specific agents. Adenosine triphosphate-based chemotherapy response assay (ATP-CRA) was employed to retrieve chemoresponse to 5-fluorouracil (5-FU), doxetaxel, doxorubicin, epirubicin, and paclitaxel in 49 patients. Tumors with high histologic and nuclear grade have higher response rate to doxorubicin (P<0.05) and palitaxel (P<0.05). Estrogen receptor (ER)-negative tumors respond well to doxorubicin (P=0.038), and progesterone receptor (PR)-negative tumors to 5-FU (P=0.039), doxetaxel (P=0.038), doxorubicin (P=0.000), epirubicin (P=0.010), and paclitaxel (P=0.003). Among the breast cancer subtypes determined by ER, PR, and HER-2 immunohistochemical stains, the HER-2+/ER subtype has a higher response rate to doxorubicin (P=0.008). This in vitro result suggests that the combination of histologic and nuclear grade, hormone receptor, and HER-2 sta tus can be a predictive factor of response to specific chemotherapy agents. Further in vivo study should be followed for clinical trials.",
author = "Koo, {Ja Seung} and Woohee Jung and Eunah Shin and Lee, {Hy de} and Joon Jeong and Kim, {Kun Hong} and Hyeongjae Jeong and Hong, {Soon Won}",
year = "2009",
month = "12",
day = "1",
doi = "10.3346/jkms.2009.24.6.1150",
language = "English",
volume = "24",
pages = "1150--1157",
journal = "Journal of Korean Medical Science",
issn = "1011-8934",
publisher = "Korean Academy of Medical Science",
number = "6",

}

Impact of grade, hormone receptor, and HER-2 status in women with breast cancer on response to specific chemotherapeutic agents by in vitro adenosine triphosphate-based chemotherapy response assay. / Koo, Ja Seung; Jung, Woohee; Shin, Eunah; Lee, Hy de; Jeong, Joon; Kim, Kun Hong; Jeong, Hyeongjae; Hong, Soon Won.

In: Journal of Korean medical science, Vol. 24, No. 6, 01.12.2009, p. 1150-1157.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of grade, hormone receptor, and HER-2 status in women with breast cancer on response to specific chemotherapeutic agents by in vitro adenosine triphosphate-based chemotherapy response assay

AU - Koo, Ja Seung

AU - Jung, Woohee

AU - Shin, Eunah

AU - Lee, Hy de

AU - Jeong, Joon

AU - Kim, Kun Hong

AU - Jeong, Hyeongjae

AU - Hong, Soon Won

PY - 2009/12/1

Y1 - 2009/12/1

N2 - This study was designed to assess whether histological and biological factors of breast cancer can predict chemoresponse to specific agents. Adenosine triphosphate-based chemotherapy response assay (ATP-CRA) was employed to retrieve chemoresponse to 5-fluorouracil (5-FU), doxetaxel, doxorubicin, epirubicin, and paclitaxel in 49 patients. Tumors with high histologic and nuclear grade have higher response rate to doxorubicin (P<0.05) and palitaxel (P<0.05). Estrogen receptor (ER)-negative tumors respond well to doxorubicin (P=0.038), and progesterone receptor (PR)-negative tumors to 5-FU (P=0.039), doxetaxel (P=0.038), doxorubicin (P=0.000), epirubicin (P=0.010), and paclitaxel (P=0.003). Among the breast cancer subtypes determined by ER, PR, and HER-2 immunohistochemical stains, the HER-2+/ER subtype has a higher response rate to doxorubicin (P=0.008). This in vitro result suggests that the combination of histologic and nuclear grade, hormone receptor, and HER-2 sta tus can be a predictive factor of response to specific chemotherapy agents. Further in vivo study should be followed for clinical trials.

AB - This study was designed to assess whether histological and biological factors of breast cancer can predict chemoresponse to specific agents. Adenosine triphosphate-based chemotherapy response assay (ATP-CRA) was employed to retrieve chemoresponse to 5-fluorouracil (5-FU), doxetaxel, doxorubicin, epirubicin, and paclitaxel in 49 patients. Tumors with high histologic and nuclear grade have higher response rate to doxorubicin (P<0.05) and palitaxel (P<0.05). Estrogen receptor (ER)-negative tumors respond well to doxorubicin (P=0.038), and progesterone receptor (PR)-negative tumors to 5-FU (P=0.039), doxetaxel (P=0.038), doxorubicin (P=0.000), epirubicin (P=0.010), and paclitaxel (P=0.003). Among the breast cancer subtypes determined by ER, PR, and HER-2 immunohistochemical stains, the HER-2+/ER subtype has a higher response rate to doxorubicin (P=0.008). This in vitro result suggests that the combination of histologic and nuclear grade, hormone receptor, and HER-2 sta tus can be a predictive factor of response to specific chemotherapy agents. Further in vivo study should be followed for clinical trials.

UR - http://www.scopus.com/inward/record.url?scp=75349086188&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=75349086188&partnerID=8YFLogxK

U2 - 10.3346/jkms.2009.24.6.1150

DO - 10.3346/jkms.2009.24.6.1150

M3 - Article

C2 - 19949674

AN - SCOPUS:75349086188

VL - 24

SP - 1150

EP - 1157

JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

SN - 1011-8934

IS - 6

ER -