Impact of Intensive LDL Cholesterol Lowering on Coronary Artery Atherosclerosis Progression: A Serial CT Angiography Study

Sanghoon Shin, Hyung Bok Park, Hyuk Jae Chang, Reza Arsanjani, James K. Min, Yong Jin Kim, Byoung Kwon Lee, Jung Hyun Choi, Geu Ru Hong, Namsik Chung

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objectives The aim of this study was to explore the relationship between temporal changes in coronary plaque volume and the intensity of lipid-lowering treatments, utilizing coronary computed tomography angiography (CTA). Background Coronary CTA has acceptable accuracy in terms of quantitative measurement of plaque volume. Although, coronary CTA is perhaps capable of identifying the differences in plaque volume progression according to the intensity of lipid lowering treatment, to date, few studies have examined this notion. Methods In this multicenter, observational study, the authors reviewed 467 patients who underwent serial coronary CTA with a scan period of more than 2 years (median 3.2 years [2.4 to 4.8]) apart, and whose laboratory data were available within 1 month of both the baseline and follow-up coronary CTA. Among them, 147 patients (comprising 336 vessels) with visible plaque were enrolled in this study. The authors performed quantitative assessment of coronary plaque in both. Patients who achieved a low-density lipoprotein cholesterol (LDL-C) with a cut off value below 70 mg/dl at follow-up were compared with those who did not. Results Patients with LDL-C below 70 mg/dl displayed a significant attenuation in plaque progression as compared with those with follow-up LDL-C levels ≥70 mg/dl (12.7 ± 38.2 mm3 vs. 44.2 ± 73.6 mm3, respectively; p = 0.014). In multivariate analysis, factors influencing plaque progression per year was follow-up LDL-C levels ≥70 mg/dl (beta 0.193; p = 0.021). Conclusions Strict LDL-C control appeared to significantly attenuate plaque volume progression based on noninvasive quantitative assessment by coronary CTA.

Original languageEnglish
Pages (from-to)437-446
Number of pages10
JournalJACC: Cardiovascular Imaging
Volume10
Issue number4
DOIs
Publication statusPublished - 2017 Apr 1

Fingerprint

LDL Cholesterol
Atherosclerosis
Arteries
Lipids
Multicenter Studies
Observational Studies
Computed Tomography Angiography
Multivariate Analysis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Shin, Sanghoon ; Park, Hyung Bok ; Chang, Hyuk Jae ; Arsanjani, Reza ; Min, James K. ; Kim, Yong Jin ; Lee, Byoung Kwon ; Choi, Jung Hyun ; Hong, Geu Ru ; Chung, Namsik. / Impact of Intensive LDL Cholesterol Lowering on Coronary Artery Atherosclerosis Progression : A Serial CT Angiography Study. In: JACC: Cardiovascular Imaging. 2017 ; Vol. 10, No. 4. pp. 437-446.
@article{ce1ba440f0f744229bb1eb0e9a196c22,
title = "Impact of Intensive LDL Cholesterol Lowering on Coronary Artery Atherosclerosis Progression: A Serial CT Angiography Study",
abstract = "Objectives The aim of this study was to explore the relationship between temporal changes in coronary plaque volume and the intensity of lipid-lowering treatments, utilizing coronary computed tomography angiography (CTA). Background Coronary CTA has acceptable accuracy in terms of quantitative measurement of plaque volume. Although, coronary CTA is perhaps capable of identifying the differences in plaque volume progression according to the intensity of lipid lowering treatment, to date, few studies have examined this notion. Methods In this multicenter, observational study, the authors reviewed 467 patients who underwent serial coronary CTA with a scan period of more than 2 years (median 3.2 years [2.4 to 4.8]) apart, and whose laboratory data were available within 1 month of both the baseline and follow-up coronary CTA. Among them, 147 patients (comprising 336 vessels) with visible plaque were enrolled in this study. The authors performed quantitative assessment of coronary plaque in both. Patients who achieved a low-density lipoprotein cholesterol (LDL-C) with a cut off value below 70 mg/dl at follow-up were compared with those who did not. Results Patients with LDL-C below 70 mg/dl displayed a significant attenuation in plaque progression as compared with those with follow-up LDL-C levels ≥70 mg/dl (12.7 ± 38.2 mm3 vs. 44.2 ± 73.6 mm3, respectively; p = 0.014). In multivariate analysis, factors influencing plaque progression per year was follow-up LDL-C levels ≥70 mg/dl (beta 0.193; p = 0.021). Conclusions Strict LDL-C control appeared to significantly attenuate plaque volume progression based on noninvasive quantitative assessment by coronary CTA.",
author = "Sanghoon Shin and Park, {Hyung Bok} and Chang, {Hyuk Jae} and Reza Arsanjani and Min, {James K.} and Kim, {Yong Jin} and Lee, {Byoung Kwon} and Choi, {Jung Hyun} and Hong, {Geu Ru} and Namsik Chung",
year = "2017",
month = "4",
day = "1",
doi = "10.1016/j.jcmg.2016.04.013",
language = "English",
volume = "10",
pages = "437--446",
journal = "JACC: Cardiovascular Imaging",
issn = "1936-878X",
publisher = "Elsevier Inc.",
number = "4",

}

Impact of Intensive LDL Cholesterol Lowering on Coronary Artery Atherosclerosis Progression : A Serial CT Angiography Study. / Shin, Sanghoon; Park, Hyung Bok; Chang, Hyuk Jae; Arsanjani, Reza; Min, James K.; Kim, Yong Jin; Lee, Byoung Kwon; Choi, Jung Hyun; Hong, Geu Ru; Chung, Namsik.

In: JACC: Cardiovascular Imaging, Vol. 10, No. 4, 01.04.2017, p. 437-446.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of Intensive LDL Cholesterol Lowering on Coronary Artery Atherosclerosis Progression

T2 - A Serial CT Angiography Study

AU - Shin, Sanghoon

AU - Park, Hyung Bok

AU - Chang, Hyuk Jae

AU - Arsanjani, Reza

AU - Min, James K.

AU - Kim, Yong Jin

AU - Lee, Byoung Kwon

AU - Choi, Jung Hyun

AU - Hong, Geu Ru

AU - Chung, Namsik

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Objectives The aim of this study was to explore the relationship between temporal changes in coronary plaque volume and the intensity of lipid-lowering treatments, utilizing coronary computed tomography angiography (CTA). Background Coronary CTA has acceptable accuracy in terms of quantitative measurement of plaque volume. Although, coronary CTA is perhaps capable of identifying the differences in plaque volume progression according to the intensity of lipid lowering treatment, to date, few studies have examined this notion. Methods In this multicenter, observational study, the authors reviewed 467 patients who underwent serial coronary CTA with a scan period of more than 2 years (median 3.2 years [2.4 to 4.8]) apart, and whose laboratory data were available within 1 month of both the baseline and follow-up coronary CTA. Among them, 147 patients (comprising 336 vessels) with visible plaque were enrolled in this study. The authors performed quantitative assessment of coronary plaque in both. Patients who achieved a low-density lipoprotein cholesterol (LDL-C) with a cut off value below 70 mg/dl at follow-up were compared with those who did not. Results Patients with LDL-C below 70 mg/dl displayed a significant attenuation in plaque progression as compared with those with follow-up LDL-C levels ≥70 mg/dl (12.7 ± 38.2 mm3 vs. 44.2 ± 73.6 mm3, respectively; p = 0.014). In multivariate analysis, factors influencing plaque progression per year was follow-up LDL-C levels ≥70 mg/dl (beta 0.193; p = 0.021). Conclusions Strict LDL-C control appeared to significantly attenuate plaque volume progression based on noninvasive quantitative assessment by coronary CTA.

AB - Objectives The aim of this study was to explore the relationship between temporal changes in coronary plaque volume and the intensity of lipid-lowering treatments, utilizing coronary computed tomography angiography (CTA). Background Coronary CTA has acceptable accuracy in terms of quantitative measurement of plaque volume. Although, coronary CTA is perhaps capable of identifying the differences in plaque volume progression according to the intensity of lipid lowering treatment, to date, few studies have examined this notion. Methods In this multicenter, observational study, the authors reviewed 467 patients who underwent serial coronary CTA with a scan period of more than 2 years (median 3.2 years [2.4 to 4.8]) apart, and whose laboratory data were available within 1 month of both the baseline and follow-up coronary CTA. Among them, 147 patients (comprising 336 vessels) with visible plaque were enrolled in this study. The authors performed quantitative assessment of coronary plaque in both. Patients who achieved a low-density lipoprotein cholesterol (LDL-C) with a cut off value below 70 mg/dl at follow-up were compared with those who did not. Results Patients with LDL-C below 70 mg/dl displayed a significant attenuation in plaque progression as compared with those with follow-up LDL-C levels ≥70 mg/dl (12.7 ± 38.2 mm3 vs. 44.2 ± 73.6 mm3, respectively; p = 0.014). In multivariate analysis, factors influencing plaque progression per year was follow-up LDL-C levels ≥70 mg/dl (beta 0.193; p = 0.021). Conclusions Strict LDL-C control appeared to significantly attenuate plaque volume progression based on noninvasive quantitative assessment by coronary CTA.

UR - http://www.scopus.com/inward/record.url?scp=85008950599&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85008950599&partnerID=8YFLogxK

U2 - 10.1016/j.jcmg.2016.04.013

DO - 10.1016/j.jcmg.2016.04.013

M3 - Article

C2 - 27771404

AN - SCOPUS:85008950599

VL - 10

SP - 437

EP - 446

JO - JACC: Cardiovascular Imaging

JF - JACC: Cardiovascular Imaging

SN - 1936-878X

IS - 4

ER -