Impact of intraoperative hyperglycaemia on renal dysfunction after off-pump coronary artery bypass

Jong Wook Song, Jae Kwang Shim, Kyung Jong Yoo, Se Young Oh, Younglan Kwak

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

OBJECTIVESAcute kidney injury (AKI) is one of the most frequently occurring complications after off-pump coronary artery bypass graft (OPCAB). Hyperglycaemia is a major, potentially modifiable risk factor of adverse outcome after cardiac surgery known to aggravate organ damage. The aim of this study was to address the association between intraoperative glucose concentration and postoperative AKI in patients who underwent OPCAB.METHODSThe medical records of 880 consecutive patients were retrospectively reviewed. Patients were divided into three groups according to the time-weighted average of intraoperative glucose concentrations (<110, 110-150 and >150 mg/dl), and the incidence of AKI (increase of serum creatinine to >2.0 mg/dl and 2 × most recent preoperative value or a new requirement for dialysis) was compared. Multivariate logistic regression analysis was performed to identify independent risk factors for postoperative AKI.RESULTSThe incidence of AKI was higher in patients with a glucose level >150 mg/dl than in patients with a glucose level = 110-150 mg/dl [8% (20 of 251) vs 3% (14 of 453), P = 0.004]. On multivariate analysis, glucose >150 mg/dl (odds ratio [OR], 2.78; 95% confidence interval [CI], 1.12-6.86, P = 0.027), coefficient of variation of glucose (OR, 1.04; 95% CI, 1.01-1.07, P = 0.027) and preoperative serum creatinine >1.4 mg/dl (OR, 8.81; 95% CI, 3.90-19.9, P < 0.001) were identified as independent risk factors for postoperative AKI.CONCLUSIONSIntraoperative glucose concentration >150 mg/dl and increased variability of glucose were independently associated with AKI after OPCAB. Tight intraoperative glycaemic control (<110 mg/dl) does not seem to provide additional benefit in terms of AKI.

Original languageEnglish
Pages (from-to)473-478
Number of pages6
JournalInteractive Cardiovascular and Thoracic Surgery
Volume17
Issue number3
DOIs
Publication statusPublished - 2013 Sep 1

Fingerprint

Off-Pump Coronary Artery Bypass
Hyperglycemia
Kidney
Glucose
Odds Ratio
Confidence Intervals
Transplants
Creatinine
Incidence
Serum
Thoracic Surgery
Medical Records
Dialysis
Multivariate Analysis
Logistic Models
Regression Analysis
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery

Cite this

Song, Jong Wook ; Shim, Jae Kwang ; Yoo, Kyung Jong ; Oh, Se Young ; Kwak, Younglan. / Impact of intraoperative hyperglycaemia on renal dysfunction after off-pump coronary artery bypass. In: Interactive Cardiovascular and Thoracic Surgery. 2013 ; Vol. 17, No. 3. pp. 473-478.
@article{1d38d7ab8ab44cc1bc454e79f0e4ce0e,
title = "Impact of intraoperative hyperglycaemia on renal dysfunction after off-pump coronary artery bypass",
abstract = "OBJECTIVESAcute kidney injury (AKI) is one of the most frequently occurring complications after off-pump coronary artery bypass graft (OPCAB). Hyperglycaemia is a major, potentially modifiable risk factor of adverse outcome after cardiac surgery known to aggravate organ damage. The aim of this study was to address the association between intraoperative glucose concentration and postoperative AKI in patients who underwent OPCAB.METHODSThe medical records of 880 consecutive patients were retrospectively reviewed. Patients were divided into three groups according to the time-weighted average of intraoperative glucose concentrations (<110, 110-150 and >150 mg/dl), and the incidence of AKI (increase of serum creatinine to >2.0 mg/dl and 2 × most recent preoperative value or a new requirement for dialysis) was compared. Multivariate logistic regression analysis was performed to identify independent risk factors for postoperative AKI.RESULTSThe incidence of AKI was higher in patients with a glucose level >150 mg/dl than in patients with a glucose level = 110-150 mg/dl [8{\%} (20 of 251) vs 3{\%} (14 of 453), P = 0.004]. On multivariate analysis, glucose >150 mg/dl (odds ratio [OR], 2.78; 95{\%} confidence interval [CI], 1.12-6.86, P = 0.027), coefficient of variation of glucose (OR, 1.04; 95{\%} CI, 1.01-1.07, P = 0.027) and preoperative serum creatinine >1.4 mg/dl (OR, 8.81; 95{\%} CI, 3.90-19.9, P < 0.001) were identified as independent risk factors for postoperative AKI.CONCLUSIONSIntraoperative glucose concentration >150 mg/dl and increased variability of glucose were independently associated with AKI after OPCAB. Tight intraoperative glycaemic control (<110 mg/dl) does not seem to provide additional benefit in terms of AKI.",
author = "Song, {Jong Wook} and Shim, {Jae Kwang} and Yoo, {Kyung Jong} and Oh, {Se Young} and Younglan Kwak",
year = "2013",
month = "9",
day = "1",
doi = "10.1093/icvts/ivt209",
language = "English",
volume = "17",
pages = "473--478",
journal = "Interactive Cardiovascular and Thoracic Surgery",
issn = "1569-9293",
publisher = "European Association for Cardio-Thoracic Surgery",
number = "3",

}

Impact of intraoperative hyperglycaemia on renal dysfunction after off-pump coronary artery bypass. / Song, Jong Wook; Shim, Jae Kwang; Yoo, Kyung Jong; Oh, Se Young; Kwak, Younglan.

In: Interactive Cardiovascular and Thoracic Surgery, Vol. 17, No. 3, 01.09.2013, p. 473-478.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of intraoperative hyperglycaemia on renal dysfunction after off-pump coronary artery bypass

AU - Song, Jong Wook

AU - Shim, Jae Kwang

AU - Yoo, Kyung Jong

AU - Oh, Se Young

AU - Kwak, Younglan

PY - 2013/9/1

Y1 - 2013/9/1

N2 - OBJECTIVESAcute kidney injury (AKI) is one of the most frequently occurring complications after off-pump coronary artery bypass graft (OPCAB). Hyperglycaemia is a major, potentially modifiable risk factor of adverse outcome after cardiac surgery known to aggravate organ damage. The aim of this study was to address the association between intraoperative glucose concentration and postoperative AKI in patients who underwent OPCAB.METHODSThe medical records of 880 consecutive patients were retrospectively reviewed. Patients were divided into three groups according to the time-weighted average of intraoperative glucose concentrations (<110, 110-150 and >150 mg/dl), and the incidence of AKI (increase of serum creatinine to >2.0 mg/dl and 2 × most recent preoperative value or a new requirement for dialysis) was compared. Multivariate logistic regression analysis was performed to identify independent risk factors for postoperative AKI.RESULTSThe incidence of AKI was higher in patients with a glucose level >150 mg/dl than in patients with a glucose level = 110-150 mg/dl [8% (20 of 251) vs 3% (14 of 453), P = 0.004]. On multivariate analysis, glucose >150 mg/dl (odds ratio [OR], 2.78; 95% confidence interval [CI], 1.12-6.86, P = 0.027), coefficient of variation of glucose (OR, 1.04; 95% CI, 1.01-1.07, P = 0.027) and preoperative serum creatinine >1.4 mg/dl (OR, 8.81; 95% CI, 3.90-19.9, P < 0.001) were identified as independent risk factors for postoperative AKI.CONCLUSIONSIntraoperative glucose concentration >150 mg/dl and increased variability of glucose were independently associated with AKI after OPCAB. Tight intraoperative glycaemic control (<110 mg/dl) does not seem to provide additional benefit in terms of AKI.

AB - OBJECTIVESAcute kidney injury (AKI) is one of the most frequently occurring complications after off-pump coronary artery bypass graft (OPCAB). Hyperglycaemia is a major, potentially modifiable risk factor of adverse outcome after cardiac surgery known to aggravate organ damage. The aim of this study was to address the association between intraoperative glucose concentration and postoperative AKI in patients who underwent OPCAB.METHODSThe medical records of 880 consecutive patients were retrospectively reviewed. Patients were divided into three groups according to the time-weighted average of intraoperative glucose concentrations (<110, 110-150 and >150 mg/dl), and the incidence of AKI (increase of serum creatinine to >2.0 mg/dl and 2 × most recent preoperative value or a new requirement for dialysis) was compared. Multivariate logistic regression analysis was performed to identify independent risk factors for postoperative AKI.RESULTSThe incidence of AKI was higher in patients with a glucose level >150 mg/dl than in patients with a glucose level = 110-150 mg/dl [8% (20 of 251) vs 3% (14 of 453), P = 0.004]. On multivariate analysis, glucose >150 mg/dl (odds ratio [OR], 2.78; 95% confidence interval [CI], 1.12-6.86, P = 0.027), coefficient of variation of glucose (OR, 1.04; 95% CI, 1.01-1.07, P = 0.027) and preoperative serum creatinine >1.4 mg/dl (OR, 8.81; 95% CI, 3.90-19.9, P < 0.001) were identified as independent risk factors for postoperative AKI.CONCLUSIONSIntraoperative glucose concentration >150 mg/dl and increased variability of glucose were independently associated with AKI after OPCAB. Tight intraoperative glycaemic control (<110 mg/dl) does not seem to provide additional benefit in terms of AKI.

UR - http://www.scopus.com/inward/record.url?scp=84882745041&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882745041&partnerID=8YFLogxK

U2 - 10.1093/icvts/ivt209

DO - 10.1093/icvts/ivt209

M3 - Article

C2 - 23690431

AN - SCOPUS:84882745041

VL - 17

SP - 473

EP - 478

JO - Interactive Cardiovascular and Thoracic Surgery

JF - Interactive Cardiovascular and Thoracic Surgery

SN - 1569-9293

IS - 3

ER -