Impact of periprocedural myonecrosis on clinical events after implantation of drug-eluting stents

Jae Sik Jang, Myeong Ki Hong, Duk Woo Park, Seung Whan Lee, Young Hak Kim, Cheol Whan Lee, Jae Joong Kim, Seong Wook Park, Seung Jung Park

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: High level of creatine kinase myocardial band isoenzyme (CK-MB) elevation has been associated with late mortality after coronary intervention. We sought to evaluate the impact of periprocedural myonecrosis on clinical events in patients undergoing drug-eluting stents (DES) implantation. Methods: A total of 1807 patients (2550 lesions) with successful DES implantation were followed for mean duration of 13 ± 7 months. Patients with acute myocardial infarction and those with elevated CK-MB at baseline were excluded. Based on the CK-MB levels after stenting, patients were classified into three groups: group I: normal CK-MB (n = 1429, 79.1%), group II: 1 to 5 times normal CK-MB (n = 263, 14.6%), and group III: > 5 times normal CK-MB (n = 115, 6.4%). Major adverse cardiac events (MACE) were defined as cardiac death, myocardial infarction, and target lesion revascularization. Results: With increasing levels of periprocedural CK-MB, there was an increased incidence of MACE (5.0% in group I vs. 6.1% in group II vs. 10.4% in group III, p = 0.010) and cardiac death (0.5% in group I vs. 1.1% in group II vs. 2.6% in group III, p = 0.016). By multivariate analysis, periprocedural peak CK-MB level was independent predictor of MACE (hazard ratio 1.01, 95% confidence interval 1.00 to 1.03; p = 0.044). Conclusions: Periprocedural myonecrosis was significantly associated with subsequent adverse clinical events after DES implantation.

Original languageEnglish
Pages (from-to)368-372
Number of pages5
JournalInternational Journal of Cardiology
Volume129
Issue number3
DOIs
Publication statusPublished - 2008 Oct 13

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Impact of periprocedural myonecrosis on clinical events after implantation of drug-eluting stents'. Together they form a unique fingerprint.

  • Cite this

    Jang, J. S., Hong, M. K., Park, D. W., Lee, S. W., Kim, Y. H., Lee, C. W., Kim, J. J., Park, S. W., & Park, S. J. (2008). Impact of periprocedural myonecrosis on clinical events after implantation of drug-eluting stents. International Journal of Cardiology, 129(3), 368-372. https://doi.org/10.1016/j.ijcard.2007.07.125