Abstract
Background Peritoneal carcinomatosis can influence clinical outcomes of patients receiving self-expandable metal stents (SEMS) for malignant colorectal obstruction, but data regarding this issue are sparse. We analyzed the clinical outcomes of post-SEMS insertion for malignant colorectal obstruction based on carcinomatosis status. Methods Stent- and patient-related clinical outcomes were compared for carcinomatosis status in a retrospective review involving 323 consecutive patients (colorectal cancer 198 patients; extracolonic malignancy 125 patients) who underwent palliative SEMS placement for malignant colorectal obstruction from January 2005 to March 2012.ŠSeverity of carcinomatosis was classified as mild, moderate, or severe. Results Carcinomatosis was observed in 190 patients (58.8Š%). The rates of technical (84.7 vs. 94.7Š%; P Š=Š0.005) and clinical (73.2 vs. 83.5Š%; P Š=Š0.03) success were lower in patients with vs. without carcinomatosis. Rates of early (2.1Š% vs. 3.0Š%; P Š=Š0.72) and delayed (1.6Š% vs. 6.0Š%; P Š=Š0.08) perforation and stent failure (27.9Š% vs. 26.3Š%; P Š=Š0.75) showed no difference. Technical and clinical success rates were significantly different based on the severity of carcinomatosis (technical success rate: mild 90.7Š%, moderate 97.4Š%, severe 76.3Š%, P Š=Š0.003; clinical success rate: mild 83.3Š%, moderate 82.1Š%, severe 63.9Š%, P Š=Š0.01). In multivariate analysis, severe carcinomatosis was identified as an independent factor related to technical (odds ratio [OR] 0.18, 95Š% confidence interval [CI] 0.06Š-Š0.56) and clinical (OR 0.33, 95Š%CI 0.15Š-Š0.74) success. Conclusions Peritoneal carcinomatosis was associated with decreased technical and clinical success rates in patients receiving SEMS for malignant colorectal obstruction. Moreover, the presence of severe carcinomatosis was an independent factor determining these clinical outcomes.
| Original language | English |
|---|---|
| Pages (from-to) | 1163-1174 |
| Number of pages | 12 |
| Journal | Endoscopy |
| Volume | 50 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2018 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Gastroenterology
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Impact of peritoneal carcinomatosis on clinical outcomes of patients receiving self-expandable metal stents for malignant colorectal obstruction. / Park, Jae Jun; Rhee, Kwangwon; Yoon, Jin Young; Park, Soo Jung; Kim, Joo Hee; Kim, Jie Hyun; Youn, Young Hoon; Kim, Tae Il; Park, Hyojin; Kim, Won Ho; Cheon, Jae Hee.
In: Endoscopy, Vol. 50, No. 12, 01.01.2018, p. 1163-1174.Research output: Contribution to journal › Article
TY - JOUR
T1 - Impact of peritoneal carcinomatosis on clinical outcomes of patients receiving self-expandable metal stents for malignant colorectal obstruction
AU - Park, Jae Jun
AU - Rhee, Kwangwon
AU - Yoon, Jin Young
AU - Park, Soo Jung
AU - Kim, Joo Hee
AU - Kim, Jie Hyun
AU - Youn, Young Hoon
AU - Kim, Tae Il
AU - Park, Hyojin
AU - Kim, Won Ho
AU - Cheon, Jae Hee
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Background Peritoneal carcinomatosis can influence clinical outcomes of patients receiving self-expandable metal stents (SEMS) for malignant colorectal obstruction, but data regarding this issue are sparse. We analyzed the clinical outcomes of post-SEMS insertion for malignant colorectal obstruction based on carcinomatosis status. Methods Stent- and patient-related clinical outcomes were compared for carcinomatosis status in a retrospective review involving 323 consecutive patients (colorectal cancer 198 patients; extracolonic malignancy 125 patients) who underwent palliative SEMS placement for malignant colorectal obstruction from January 2005 to March 2012.ŠSeverity of carcinomatosis was classified as mild, moderate, or severe. Results Carcinomatosis was observed in 190 patients (58.8Š%). The rates of technical (84.7 vs. 94.7Š%; P Š=Š0.005) and clinical (73.2 vs. 83.5Š%; P Š=Š0.03) success were lower in patients with vs. without carcinomatosis. Rates of early (2.1Š% vs. 3.0Š%; P Š=Š0.72) and delayed (1.6Š% vs. 6.0Š%; P Š=Š0.08) perforation and stent failure (27.9Š% vs. 26.3Š%; P Š=Š0.75) showed no difference. Technical and clinical success rates were significantly different based on the severity of carcinomatosis (technical success rate: mild 90.7Š%, moderate 97.4Š%, severe 76.3Š%, P Š=Š0.003; clinical success rate: mild 83.3Š%, moderate 82.1Š%, severe 63.9Š%, P Š=Š0.01). In multivariate analysis, severe carcinomatosis was identified as an independent factor related to technical (odds ratio [OR] 0.18, 95Š% confidence interval [CI] 0.06Š-Š0.56) and clinical (OR 0.33, 95Š%CI 0.15Š-Š0.74) success. Conclusions Peritoneal carcinomatosis was associated with decreased technical and clinical success rates in patients receiving SEMS for malignant colorectal obstruction. Moreover, the presence of severe carcinomatosis was an independent factor determining these clinical outcomes.
AB - Background Peritoneal carcinomatosis can influence clinical outcomes of patients receiving self-expandable metal stents (SEMS) for malignant colorectal obstruction, but data regarding this issue are sparse. We analyzed the clinical outcomes of post-SEMS insertion for malignant colorectal obstruction based on carcinomatosis status. Methods Stent- and patient-related clinical outcomes were compared for carcinomatosis status in a retrospective review involving 323 consecutive patients (colorectal cancer 198 patients; extracolonic malignancy 125 patients) who underwent palliative SEMS placement for malignant colorectal obstruction from January 2005 to March 2012.ŠSeverity of carcinomatosis was classified as mild, moderate, or severe. Results Carcinomatosis was observed in 190 patients (58.8Š%). The rates of technical (84.7 vs. 94.7Š%; P Š=Š0.005) and clinical (73.2 vs. 83.5Š%; P Š=Š0.03) success were lower in patients with vs. without carcinomatosis. Rates of early (2.1Š% vs. 3.0Š%; P Š=Š0.72) and delayed (1.6Š% vs. 6.0Š%; P Š=Š0.08) perforation and stent failure (27.9Š% vs. 26.3Š%; P Š=Š0.75) showed no difference. Technical and clinical success rates were significantly different based on the severity of carcinomatosis (technical success rate: mild 90.7Š%, moderate 97.4Š%, severe 76.3Š%, P Š=Š0.003; clinical success rate: mild 83.3Š%, moderate 82.1Š%, severe 63.9Š%, P Š=Š0.01). In multivariate analysis, severe carcinomatosis was identified as an independent factor related to technical (odds ratio [OR] 0.18, 95Š% confidence interval [CI] 0.06Š-Š0.56) and clinical (OR 0.33, 95Š%CI 0.15Š-Š0.74) success. Conclusions Peritoneal carcinomatosis was associated with decreased technical and clinical success rates in patients receiving SEMS for malignant colorectal obstruction. Moreover, the presence of severe carcinomatosis was an independent factor determining these clinical outcomes.
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U2 - 10.1055/a-0657-3764
DO - 10.1055/a-0657-3764
M3 - Article
C2 - 30170328
AN - SCOPUS:85057440656
VL - 50
SP - 1163
EP - 1174
JO - Endoscopy
JF - Endoscopy
SN - 0013-726X
IS - 12
ER -