Impact of preoperative calculation of nephron volume loss on future of partial nephrectomy techniques; planning a strategic roadmap for improving functional preservation and securing oncological safety

Koon H. Rha, Ali Abdel Raheem, Sung Y. Park, Kwang H. Kim, Hyung J. Kim, Kyo C. Koo, Young D. Choi, Byung H. Jung, Sang K. Lee, Won K. Lee, Jayram Krishnan, Tae Y. Shin, Jin Seon Cho

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives: To assess the correlation of the resected and ischaemic volume (RAIV), which is a preoperatively calculated volume of nephron loss, with the amount of postoperative renal function (PRF) decline after minimally invasive partial nephrectomy (PN) in a multi-institutional dataset. Patients and Methods: We identified 348 patients from March 2005 to December 2013 at six institutions. Data on all cases of laparoscopic (n = 85) and robot-assisted PN (n = 263) performed were retrospectively gathered. Univariable and multivariable linear regression analyses were used to identify the associations between various time points of PRF and the RAIV, as a continuous variable. Results: The mean (sd) RAIV was 24.2 (29.2) cm3. The mean preoperative estimated glomerular filtration rate (eGFR) and the eGFRs at postoperative day 1, 6 and 36 months after PN were 91.0 and 76.8, 80.2 and 87.7 mL/min/1.73 m2, respectively. In multivariable linear regression analysis, the amount of decline in PRF at follow-up was significantly correlated with the RAIV (β 0.261, 0.165, 0.260 at postoperative day 1, 6 and 36 months after PN, respectively). This study has the limitation of its retrospective nature. Conclusion: Preoperatively calculated RAIV significantly correlates with the amount of decline in PRF during long-term follow-up. The RAIV could lead our research to the level of prediction of the amount of PRF decline after PN and thus would be appropriate for assessing the technical advantages of emerging techniques.

Original languageEnglish
Pages (from-to)682-688
Number of pages7
JournalBJU International
Volume120
Issue number5
DOIs
Publication statusPublished - 2017 Nov

Bibliographical note

Funding Information:
The study was supported by a grant from the Hallym University Research Fund (HURF-2015-01).

All Science Journal Classification (ASJC) codes

  • Urology

Fingerprint Dive into the research topics of 'Impact of preoperative calculation of nephron volume loss on future of partial nephrectomy techniques; planning a strategic roadmap for improving functional preservation and securing oncological safety'. Together they form a unique fingerprint.

Cite this