Impact of prolonged temporal discrimination threshold on finger movements of Parkinson's disease

M. J. Lee, J. S. Son, J. H. Lee, S. J. Kim, C. H. Lyoo, M. S. Lee

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Introduction Sensory information is essential for the precise control of movement. Patients with Parkinson's disease (PD) have higher-order sensory dysfunctions including prolonged temporal discrimination threshold (TDT). However, the impact of prolonged TDT on parkinsonian motor deficits is uncertain. Methods This study includes 33 PD patients and 24 healthy controls. TDT values were measured in the index finger. Using coin rotation task (CRT), dexterous finger movement was assessed. Using an inertial sensor, the speed, amplitude, and frequency of finger tapping were measured. The impact of prolonged index finger TDT on two different finger movements was analyzed using the general estimating equation. Results Compared to healthy controls, TDT was prolonged in the PD patients. There was no impact of TDT on mean values or decrement for amplitude and speed, as well as mean values, decrement and variability of tapping frequency. However, prolonged TDT had a significant impact on the variability in amplitude (B = 436.905 × 10-4 , Wald ?2 = 9.140, p = 0.014) and speed (B = 425.655 × 10-4 , Wald ?2 = 9.876, p = 0.014) of finger tapping. There was a marginal correlation between TDT and CRT. In addition, CRT correlated with variability in amplitude and speed of finger tapping.Conclusion In PD, cutaneous temporal discriminative sensory dysfunction appears to be related to increased variabilities in the speed and amplitude of fast repetitive finger movements and disturbed finger dexterity.

Original languageEnglish
Article numbere0167034
JournalPloS one
Volume11
Issue number11
DOIs
Publication statusPublished - 2016 Nov

Fingerprint

Parkinson disease
Fingers
Parkinson Disease
Numismatics
sensors (equipment)
Sensors
Skin
methodology

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Lee, M. J. ; Son, J. S. ; Lee, J. H. ; Kim, S. J. ; Lyoo, C. H. ; Lee, M. S. / Impact of prolonged temporal discrimination threshold on finger movements of Parkinson's disease. In: PloS one. 2016 ; Vol. 11, No. 11.
@article{c0f0ce5b8f524ab2aa0670807c54a4a0,
title = "Impact of prolonged temporal discrimination threshold on finger movements of Parkinson's disease",
abstract = "Introduction Sensory information is essential for the precise control of movement. Patients with Parkinson's disease (PD) have higher-order sensory dysfunctions including prolonged temporal discrimination threshold (TDT). However, the impact of prolonged TDT on parkinsonian motor deficits is uncertain. Methods This study includes 33 PD patients and 24 healthy controls. TDT values were measured in the index finger. Using coin rotation task (CRT), dexterous finger movement was assessed. Using an inertial sensor, the speed, amplitude, and frequency of finger tapping were measured. The impact of prolonged index finger TDT on two different finger movements was analyzed using the general estimating equation. Results Compared to healthy controls, TDT was prolonged in the PD patients. There was no impact of TDT on mean values or decrement for amplitude and speed, as well as mean values, decrement and variability of tapping frequency. However, prolonged TDT had a significant impact on the variability in amplitude (B = 436.905 × 10-4 , Wald ?2 = 9.140, p = 0.014) and speed (B = 425.655 × 10-4 , Wald ?2 = 9.876, p = 0.014) of finger tapping. There was a marginal correlation between TDT and CRT. In addition, CRT correlated with variability in amplitude and speed of finger tapping.Conclusion In PD, cutaneous temporal discriminative sensory dysfunction appears to be related to increased variabilities in the speed and amplitude of fast repetitive finger movements and disturbed finger dexterity.",
author = "Lee, {M. J.} and Son, {J. S.} and Lee, {J. H.} and Kim, {S. J.} and Lyoo, {C. H.} and Lee, {M. S.}",
year = "2016",
month = "11",
doi = "10.1371/journal.pone.0167034",
language = "English",
volume = "11",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "11",

}

Impact of prolonged temporal discrimination threshold on finger movements of Parkinson's disease. / Lee, M. J.; Son, J. S.; Lee, J. H.; Kim, S. J.; Lyoo, C. H.; Lee, M. S.

In: PloS one, Vol. 11, No. 11, e0167034, 11.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of prolonged temporal discrimination threshold on finger movements of Parkinson's disease

AU - Lee, M. J.

AU - Son, J. S.

AU - Lee, J. H.

AU - Kim, S. J.

AU - Lyoo, C. H.

AU - Lee, M. S.

PY - 2016/11

Y1 - 2016/11

N2 - Introduction Sensory information is essential for the precise control of movement. Patients with Parkinson's disease (PD) have higher-order sensory dysfunctions including prolonged temporal discrimination threshold (TDT). However, the impact of prolonged TDT on parkinsonian motor deficits is uncertain. Methods This study includes 33 PD patients and 24 healthy controls. TDT values were measured in the index finger. Using coin rotation task (CRT), dexterous finger movement was assessed. Using an inertial sensor, the speed, amplitude, and frequency of finger tapping were measured. The impact of prolonged index finger TDT on two different finger movements was analyzed using the general estimating equation. Results Compared to healthy controls, TDT was prolonged in the PD patients. There was no impact of TDT on mean values or decrement for amplitude and speed, as well as mean values, decrement and variability of tapping frequency. However, prolonged TDT had a significant impact on the variability in amplitude (B = 436.905 × 10-4 , Wald ?2 = 9.140, p = 0.014) and speed (B = 425.655 × 10-4 , Wald ?2 = 9.876, p = 0.014) of finger tapping. There was a marginal correlation between TDT and CRT. In addition, CRT correlated with variability in amplitude and speed of finger tapping.Conclusion In PD, cutaneous temporal discriminative sensory dysfunction appears to be related to increased variabilities in the speed and amplitude of fast repetitive finger movements and disturbed finger dexterity.

AB - Introduction Sensory information is essential for the precise control of movement. Patients with Parkinson's disease (PD) have higher-order sensory dysfunctions including prolonged temporal discrimination threshold (TDT). However, the impact of prolonged TDT on parkinsonian motor deficits is uncertain. Methods This study includes 33 PD patients and 24 healthy controls. TDT values were measured in the index finger. Using coin rotation task (CRT), dexterous finger movement was assessed. Using an inertial sensor, the speed, amplitude, and frequency of finger tapping were measured. The impact of prolonged index finger TDT on two different finger movements was analyzed using the general estimating equation. Results Compared to healthy controls, TDT was prolonged in the PD patients. There was no impact of TDT on mean values or decrement for amplitude and speed, as well as mean values, decrement and variability of tapping frequency. However, prolonged TDT had a significant impact on the variability in amplitude (B = 436.905 × 10-4 , Wald ?2 = 9.140, p = 0.014) and speed (B = 425.655 × 10-4 , Wald ?2 = 9.876, p = 0.014) of finger tapping. There was a marginal correlation between TDT and CRT. In addition, CRT correlated with variability in amplitude and speed of finger tapping.Conclusion In PD, cutaneous temporal discriminative sensory dysfunction appears to be related to increased variabilities in the speed and amplitude of fast repetitive finger movements and disturbed finger dexterity.

UR - http://www.scopus.com/inward/record.url?scp=84997109197&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84997109197&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0167034

DO - 10.1371/journal.pone.0167034

M3 - Article

C2 - 27893840

AN - SCOPUS:84997109197

VL - 11

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 11

M1 - e0167034

ER -